Our URP1 rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects bovine, canine, human, mouse, non-human primate, rat, Xenopus URP1 and is antigen affinity purified. It is great for use in WB.
Western Blot of 20 ug of human lung adenocarcinoma cell line NCI-H322 lysate showing specific immunolabeling of Kindlin.
Bovine, Canine, Human, Mouse, Non-Human Primate, Rat, Xenopus
Due to a concerted effort to identify biomarkers for lung and colon carcinomas by genome-wide transcriptional profiling, the identification and cloning of one such gene as well as two additional closely related genes was achieved. Due to the strong sequence homology to the C. elegans UNC-112 a novel gene gene was named URP1, for UNC-112 related protein. Another novel related gene, URP2 and the previously discovered MIG-2 gene was also identified. Transcriptional analysis shows that only URP1 is significantly differentially regulated, being over-expressed in 70% of the colon carcinomas and 60% of the lung carcinomas tested. Quantification of URP1 expression by qRT-PCR showed up-regulation of the gene by 60-fold in lung tumors and up to nearly 6-fold in colon tumors. Northern blot analysis of URP1 indicates that normal expression is restricted to neuromuscular tissues. In contrast, the expression of URP2 appears to be confined primarily to tissues of the immune system. URP1 has the potential to be one of the most important prognostic and diagnostic markers of colon or lung cancer.
Antigen Affinity Purified
Polyclonal
IgG
WB
Rabbit
FERMT1
Synthetic peptide corresponding to amino acids from the C-terminal region of human URP1.
Bovine, Canine, Human, Mouse, Non-Human Primate, Rat, Xenopus
Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.
Liquid
PBS + 0.02% NaN3
WB: 1:500-1:1000
WB Brain: 1:500-1:1000
Reacts with the C-terminal region of the 77 kDa human URP1 protein. Sequence is 100% conserved between almost all species (mouse, rat, canine, bovine, chimpanzee, Xenopus).
Western blots performed on each lot.
For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
United States
After date of receipt, stable for at least 1 year at -20°C.
Blue Ice
FERMT1, Fermitin family homolog 1, Kindlerin, Kindlin syndrome protein, Unc-112-related protein 1, C20orf42, KIND1
