Anti-Kir2.2 K+ Channel Antibody (N124B/38)
Our Anti-Kir2.2 K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N124B/38. It detects rat Kir2.2 K+ channel, and is purified by Protein A chromatography. It is great for use in ICC, WB.
SKU: 75-203
Product Details
Kir2.2 K+ channel
ATP-sensitive inward rectifier potassium channel 12or Kir2.2 is encoded by the gene KCNJ12. Kir2.2 is a member of the inward rectifier potassium ion channel family and plays a role controlling the resting membrane potential in muscle cells and neurons. Kir2.2 is an integral membrane protein that is expressed in heart, brain and in aortic endothelial cells. In brain, Kir2.2 is expressed throughout the forebrain and cerebellum. Diseases associated with KCNJ12 include Smith-Magenis Syndrome and Leber Congenital Amaurosis 16.
Purified by Protein A chromatography
1 mg/mL
Monoclonal
N124B/38
IgG1
ICC, WB
Mouse
Kcnj12 Irk2
48 kDa
Synthetic peptide amino acids 390-410 (cytoplasmic C-terminus) of rat Kir2.2 (accession number P52188)
Rat
AB_2130486
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125
Unconjugated
No cross-reactivity against Kir2.1 or Kir2.3
Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
United States
24 months from date of receipt
Shipped on ice packs
ATP-sensitive inward rectifier potassium channel 12 (Inward rectifier K(+) channel Kir2.2) (IRK-2) (Potassium channel, inwardly rectifying subfamily J member 12)
UniProt (Human): Q14500
UniProt (Immunogen Species): P52188
UniProt (Immunogen Species): P52188
- Zhang X, Ai X, Nakayama H, Chen B, Harris DM, Tang M, Xie Y, Szeto C, Li Y, Li Y, Zhang H, Eckhart AD, Koch WJ, Molkentin JD, Chen X. (2016), 'Persistent increases in Ca(2+) influx through Cav1.2 shortens action potential and causes Ca(2+) overload-induced afterdepolarizations and arrhythmias..' Basic Research in Cardiology. 10.1007/s00395-015-0523-4.
- DiFranco M, Yu C, Quiñonez M, Vergara JL. (2015), 'Inward rectifier potassium currents in mammalian skeletal muscle fibres..' The Journal of Physiology. 10.1113/jphysiol.2014.283648.
- Cheng L, Yung A, Covarrubias M, Radice GL. (2011), 'Cortactin is required for N-cadherin regulation of Kv1.5 channel function..' The Journal of Biological Chemistry. 10.1074/jbc.M111.218560.
- Vaidyanathan R, Taffet SM, Vikstrom KL, Anumonwo JM. (2010), 'Regulation of cardiac inward rectifier potassium current (I(K1)) by synapse-associated protein-97..' The Journal of Biological Chemistry. 10.1074/jbc.M110.110858.