Anti-Pan-Kvbeta Potassium Channel Antibody (K25/73)

Name: Anti-Pan-Kvbeta Potassium Channel Antibody
Brand: NeuroMab
SKU: 75-392
Price: 319.0 USD
Availability: InStock

2 Citations

Our Anti-Pan-Kvbeta potassium channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K25/73. It detects human, mouse, and rat Pan-Kvbeta potassium channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.

Adult rat brain membrane immunoblot

Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC, WB

Host Species

Mouse

Available Conjugates

490

550

594

650

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Data Sheet

SKU: 75-392

Product Details

Target

Pan-Kvbeta potassium channel

Target Description

The ß subunits of voltage-gated potassium channels are members of the potassium channel, voltage-gated, shaker-related subfamily. Kvβs are cytoplasmic subunits that modulate the characteristics of the membrane spanning, channel-forming alpha-subunits. Beta subunits can promote the closure of channels or enhance channel activity depending on other channel proteins. There are three ß subunits (Kvß1, Kvß2, Kvß3) which are coded by three different genes. Additionally, there is alternative splicing of these three genes, further diversifying the functions and tissue expression of the family.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

K25/73

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Kcnab1 Kvb1 Kcnab3 Ckbeta3 Kcnab2 Ckbeta2 Kcnb3

Molecular Weight

40 kDa

Antigen

Synthetic peptide amino acids 350-367 (EIDSILGNKPYSKKDYRS, C-terminus) of human Kvbeta2 (accession number Q13303)

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2491089

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

Reacts with Kvbeta1

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Voltage-gated potassium channel subunit beta-1 (EC 1.1.1.-) (K(+) channel subunit beta-1) (Kv-beta-1) Voltage-gated potassium channel subunit beta-3 (K(+) channel subunit beta-3) (Kv-beta-3) (RCK beta3) Voltage-gated potassium channel subunit beta-2 (EC 1.1.1.-) (K(+) channel subunit beta-2) (Kv-beta-2)

UniProt Details

UniProt (Human): Q13303
UniProt (Immunogen Species): Q13303

Product Specific References for Applications and Species

Immunocytochemistry: Rat
Western Blot: Mouse

Immunocytochemistry: Rat
PMID	Dilution	Publication
21357749	not listed	Vacher, H., et al. 2011. Cdk-mediated phosphorylation of the Kvβ2 auxiliary subunit regulates Kv1 channel axonal targeting.. The Journal of Biology, 813-24.

Western Blot: Mouse
PMID	Dilution	Publication
33157003	not listed	Kuijpers, M., et al. 2021. Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum. Neuron, 299-313.

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Anti-Pan-Kvbeta Potassium Channel Antibody (K25/73)

SKU: 75-392

Product Details

Product Specific References for Applications and Species

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