Anti-TARPGamma2/4/8 Antibody (N245/36)
Our Anti-TARPGamma2/4/8 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N245/36. It detects mouse and rat TARPGamma2/4/8, and is purified by Protein A chromatography. It is great for use in ICC, WB.
SKU: 75-252
Product Details
TARPGamma2/4/8
Voltage-dependent calcium channel gamma-2 subunit, TARPGamma2 or Stargazin is encoded by the gene CACNG2 and is the transmembrane gamma subunit of the L-type calcium channel. Stargazin is in involved in regulation and trafficking of the ligand gated ion channel AMPA receptors. It is thought to play a role in learning and memory. Diseases associated with this gene include forms of deafness, Mental Retardation and childhood absnce epilepsy.
Purified by Protein A chromatography
1 mg/mL
Monoclonal
N245/36
IgG2a
ICC, WB
Mouse
Cacng2 Stg Cacng4 Cacng8
36 kDa
Fusion protein amino acids 203-323 (cytoplasmic C-terminus) of rat TARPGamma2 (accession number Q71RJ2) produced recombinantly in E. Coli
Mouse, Rat
AB_10676103
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125
Unconjugated
Cross-react with TARPGamma4 and TARPGamma8Does not cross-react with TARPGamma3
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
United States
24 months from date of receipt
Shipped on ice packs
Voltage-dependent calcium channel gamma-2 subunit (Neuronal voltage-gated calcium channel gamma-2 subunit) (Stargazin) (Transmembrane AMPAR regulatory protein gamma-2) (TARP gamma-2) Voltage-dependent calcium channel gamma-4 subunit (Neuronal voltage-gated calcium channel gamma-4 subunit) (Transmembrane AMPAR regulatory protein gamma-4) (TARP gamma-4) Voltage-dependent calcium channel gamma-8 subunit (Neuronal voltage-gated calcium channel gamma-8 subunit) (Transmembrane AMPAR regulatory protein gamma-8) (TARP gamma-8)
UniProt (Human): Q9Y698
UniProt (Immunogen Species): Q71RJ2
UniProt (Immunogen Species): Q71RJ2
- Schwenk J, Baehrens D, Haupt A, Bildl W, Boudkkazi S, Roeper J, Fakler B, Schulte U. (2014), 'Regional diversity and developmental dynamics of the AMPA-receptor proteome in the mammalian brain..' Neuron.. 10.1016/j.neuron.2014.08.044.
- Boudkkazi S, Brechet A, Schwenk J, Fakler B. (2014), 'Cornichon2 dictates the time course of excitatory transmission at individual hippocampal synapses..' Neuron.. 10.1016/j.neuron.2014.03.031.
- Tao Y, Chen YJ, Shen C, Luo Z, Bates CR, Lee D, Marchetto S, Gao TM, Borg JP, Xiong WC, Mei L. (2013), 'Erbin interacts with TARP γ-2 for surface expression of AMPA receptors in cortical interneurons..' Nat Neurosci.. 10.1038/nn.3320.
- Nagura H, Ishikawa Y, Kobayashi K, Takao K, Tanaka T, Nishikawa K, Tamura H, Shiosaka S, Suzuki H, Miyakawa T, Fujiyoshi Y, Doi T. (2012), 'Impaired synaptic clustering of postsynaptic density proteins and altered signal transmission in hippocampal neurons, and disrupted learning behavior in PDZ1 and PDZ2 ligand binding-deficient PSD-95 knockin mice..' Mol Brain.. 10.1186/1756-6606-5-43.