Anti-Thorase/Atad1 Antibody (N125/10)
Our Anti-Thorase/Atad1 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N125/10. It is KO validated, detects human, mouse, and rat Thorase/Atad1, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.
Human, Mouse, Rat
ICC, IHC, WB
Mouse
KO Validated
SKU: 75-157
Product Details
Thorase/Atad1
ATPase Family AAA Domain-containing 1 is encoded by the gene ATAD1. ATAD1 plays a critical role in regulating the surface expression of AMPA receptors thereby regulating synaptic plasticity, learning, and memory. Diseases associated with ATAD1 include Hyperekplexia 4 and Hyperekplexia.
Purified by Protein A chromatography
1 mg/mL
Monoclonal
N125/10
IgG1
ICC, IHC, WB
Mouse
Atad1
40 kDa
Fusion protein amino acids 1-361 (full-length) of mouse Thorase (accession number Q9D5T0) produced recombinantly in E. Coli
Human, Mouse, Rat
AB_2290002
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.83
Unconjugated
No cross-reactivity reported
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
United States
24 months from date of receipt
Shipped on ice packs
ATPase family AAA domain-containing protein 1 (EC 3.6.1.3) (Thorase)
UniProt (Human): Q8NBU5
UniProt (Immunogen Species): Q9D5T0
UniProt (Immunogen Species): Q9D5T0
- Prendergast J, Umanah GK, Yoo SW, Lagerlöf O, Motari MG, Cole RN, Huganir RL, Dawson TM, Dawson VL, Schnaar RL. (2014), 'Ganglioside regulation of AMPA receptor trafficking..' Journal of Neuroscience. 10.1523/JNEUROSCI.1149-14.2014.
- Zhang J, Wang Y, Chi Z, Keuss MJ, Pai YM, Kang HC, Shin JH, Bugayenko A, Wang H, Xiong Y, Pletnikov MV, Mattson MP, Dawson TM, Dawson VL. (2011), 'The AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic plasticity and behavior..' Cell. 10.1016/j.cell.2011.03.016.
- Chen YC, Umanah GK, Dephoure N, Andrabi SA, Gygi SP, Dawson TM, Dawson VL, Rutter J. (), 'Msp1/ATAD1 maintains mitochondrial function by facilitating the degradation of mislocalized tail-anchored proteins..' The EMBO Journal. 10.15252/embj.201487943.