Anti-TRIP8b (Exon 4) Antibody (N212/3)
Our Anti-TRIP8b (exon 4) mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N212/3. It is KO validated, detects human, mouse, and rat TRIP8b (exon 4), and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.
Human, Mouse, Rat
ICC, IHC, WB
Mouse
KO Validated
SKU: 75-208
Product Details
TRIP8b (exon 4)
PEX5-related protein, Peroxisomal Biogenesis Factor 5 Like, TPR-containing Rab8b-interacting protein or TRIP8b is encoded by the gene Pex5l. It is a member of the peroxisomal targeting signal receptor family. TRIP8b is a cytoplasmic accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. TRIP8b interacts with the carboxyl-terminal region of HCN channels and regulates their cell-surface expression to the dendrites in many types of neurons. TRIP8b plays a role in regulation of HCN channel cyclic nucleotide kinetics. TRIP8b is expressed in the brain. Diseases associated with PEX5L include Rhizomelic Chondrodysplasia Punctata, Type 5 and Rhizomelic Chondrodysplasia Punctata, Type 2.
Purified by Protein A chromatography
1 mg/mL
Monoclonal
N212/3
IgG1
ICC, IHC, WB
Mouse
Pex5l Pex2 Pex5r Trip8b
70 kDa
Fusion protein amino acids 1-192 (exon 1a, exon 4 and constant region) of rat TRIP8b (accession number Q925N3) produced recombinantly in E. Coli
Human, Mouse, Rat
AB_10671951
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125
Unconjugated
Specific for exon 4(does not react with TRIP8b isoforms containing exons 1a, 1b or 2)
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
United States
24 months from date of receipt
Shipped on ice packs
PEX5-related protein (PEX5-like protein) (Peroxin-5-related protein) (TPR-containing Rab8b-interacting protein) (Tetratricopeptide repeat-containing Rab8b-interacting protein) (Pex5Rp) (TRIP8b)
UniProt (Human): Q8IYB4
UniProt (Immunogen Species): Q925N3
UniProt (Immunogen Species): Q925N3
- Zhou M, Luo P, Lu Y, Li CJ, Wang DS, Lu Q, Xu XL, He Z, Guo LJ. (2015), 'Imbalance of HCN1 and HCN2 expression in hippocampal CA1 area impairs spatial learning and memory in rats with chronic morphine exposure..' Prog Neuropsychopharmacol Biol Psychiatry.. 10.1016/j.pnpbp.2014.09.010.
- Li CJ, Lu Y, Zhou M, Zong XG, Li C, Xu XL, Guo LJ, Lu Q. (2014), 'Activation of GABAB receptors ameliorates cognitive impairment via restoring the balance of HCN1/HCN2 surface expression in the hippocampal CA1 area in rats with chronic cerebral hypoperfusion..' Molecular Neurobiology. 10.1007/s12035-014-8736-3.
- Pan Y, Bhattarai S, Modestou M, Drack AV, Chetkovich DM, Baker SA. (2014), 'TRIP8b is required for maximal expression of HCN1 in the mouse retina..' PLoS One. 10.1371/journal.pone.0085850.
- Piskorowski R, Santoro B, Siegelbaum SA. (2011), 'TRIP8b splice forms act in concert to regulate the localization and expression of HCN1 channels in CA1 pyramidal neurons..' Neuron. 10.1016/j.neuron.2011.03.023.