Anti-CA19-9/Sialyl Lewis A (sLeA) Antibody FL490 Conjugate (CA19-9-203)

Name: Anti-CA19-9/Sialyl Lewis A (sLeA) Antibody FL490 Conjugate
Brand: Antibodies Incorporated
SKU: MM-1003-FL490
Price: 460.0 USD
Availability: InStock

Our Anti-CA19-9/Sialyl Lewis A (sLeA) mouse monoclonal primary antibody from Antibodies Incorporated is produced in-house from hybridoma clone CA19-9-203. It detects human CA19-9/Sialyl Lewis A (sLeA), and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Species Reactivity

Human

Applications

ICC, IHC

Host Species

Mouse

Available Conjugates

Unconjugated

550

594

650

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Data Sheet

SKU: MM-1003-FL490

Product Details

Target

CA19-9/Sialyl Lewis A (sLeA)

Target Description

CA19-9/ Sialyl Lewis a (sialyted lacto-N-fucopentose) (α-NeuNAc-(2→3)-β-D-Gal-(1→3)-(α-L-Fuc-[1→4])-D-GlcNAc, 3′-SLea) corresponds to blood group antigens. In normal tissue Sialyl Lewis a is present in ductal epithelium of the breast, kidney and salivary glands. This antigen is expressed is increased in all gastrointestinal carcinomas (stomach, intestine and pancreas) (1) While it is not useful to diagnose particular forms of cancer, specifically pancreatic cancer, it may be useful to monitor the results of treatment and to determine whether the disease may be recurring (3) Other causes for elevated CA19-9 levels include Mirizzi’s syndrome and other hepatobiliary diseases (2) In patients that do not have the Lewis antigen blood type (about 5% of the population), CA19-9 is not elevated in pancreatic cancer even with large tumors because they have a deficiency of fucosyltransferase that is needed to produce CA19-9 (1).

Format

Purified by Protein A Chromatography

Concentration

0.5 mg/mL

Clonality

Monoclonal

Clone

CA19-9-203

Isotype

IgG1

Applications

ICC, IHC

Host Species

Mouse

Molecular Weight

120-400 kDa

Antigen

Purified human mucin from ovarian cyst

Species Reactivity

Human

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL490 Ex: 491 nm, Em: 515 nm

Specificity

No cross-reactivity reported

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used in Western blot.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

CA19-9; Sialyl Lewis A; sLeA

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Anti-CA19-9/Sialyl Lewis A (sLeA) Antibody FL490 Conjugate (CA19-9-203)

SKU: MM-1003-FL490

Product Details

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