Anti-DNAIC1 Antibody (UNC 65.56.18.11)

Name: Anti-DNAIC1 Antibody
Brand: NeuroMab
SKU: 75-372
Price: 319.0 USD
Availability: InStock

Our Anti-DNAIC1 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone UNC 65.56.18.11. It is KO validated, detects human and mouse DNAIC1, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.

Immunoblot against isolated cilia and extracts of COS cells transiently transfected with GFP-tagged DNAIC1 or untagged Kv2.1 plasmid probed with UNC 65.56.18.11 (left) or N52A/42 (right) TC supe.

Species Reactivity

Human, Mouse

Applications

ICC, WB

Host Species

Mouse

Available Conjugates

490

550

594

650

Go to Full Product Details

Data Sheet

KO Validated

SKU: 75-372

Product Details

Target

DNAIC1

Target Description

Dynein intermediate chain 1, axonemal or DNAIC1 is encoded by the gene DNAI1 and is a member of the dynein intermediate chain family. DNAI1 is an intermediate chain dynein in respiratory cilia. This protein has varied functions including development of respiratory function, motility of spermatozoa, and asymmetrical organization of the viscera during embryogenesis. Diseases associated with DNAI1 include Ciliary Dyskinesia and Kartagener Syndrome.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

UNC 65.56.18.11

Isotype

IgG1

Applications

ICC, WB

Host Species

Mouse

Gene Name

DNAI1

Molecular Weight

80 kDa

Antigen

Synthetic peptide amino acids 22-41 (RGTRKRDEDSGTEVGEGTDE) of human DNAIC1 (accession number Q9UI46).

Species Reactivity

Human, Mouse

Antibody Registry ID

AB_2341107

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Dynein intermediate chain 1, axonemal (Axonemal dynein intermediate chain 1)

UniProt Details

UniProt (Human): Q9UI46
UniProt (Immunogen Species): Q9UI46

Product Specific References for Applications and Species

Immunocytochemistry: Human
Immunohistochemistry: Human | Mouse

Immunocytochemistry: Human
PMID	Dilution	Publication
35531639	1:1000	Konjikusic, M.J., et al. 2023. Kif9 is an active kinesin motor required for ciliary beating and proximodistal patterning of motile axonemes. Journal of Cell Science, jcsw259535.

Immunohistochemistry: Human
PMID	Dilution	Publication
33263282	not listed	Lee, C., et al. 2020. Functional partitioning of a liquid-like organelle during assembly of axonemal dyneins. Elife, e58662.

Immunohistochemistry: Mouse
PMID	Dilution	Publication
36149960	not listed	Cho, J.H., et al. 2022. Islet primary cilia motility controls insulin secretion. Science Advances, eabq8486.

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Anti-DNAIC1 Antibody (UNC 65.56.18.11)

SKU: 75-372

Product Details

Product Specific References for Applications and Species

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