Anti-Epithelial Cell Adhesion Molecule (Ep-CAM) Antibody FL594 Conjugate (ESA 214)

Name: Anti-Epithelial Cell Adhesion Molecule (Ep-CAM) Antibody FL594 Conjugate
Brand: Antibodies Incorporated
SKU: MM-1014-FL594
Price: 460.0 USD
Availability: InStock

Our Anti-Epithelial Cell Adhesion Molecule mouse monoclonal primary antibody from Antibodies Incorporated is produced in-house from hybridoma clone ESA 214. It detects human Epithelial Cell Adhesion Molecule, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Species Reactivity

Human

Applications

ICC, IHC

Host Species

Mouse

Available Conjugates

Unconjugated

490

550

650

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Data Sheet

SKU: MM-1014-FL594

Product Details

Target

Epithelial Cell Adhesion Molecule

Target Description

Epithelial specific antigen is a transmembrane glycoprotein (40 kDa) also known as ESA or epithelial cellular adhesion molecule (Ep-CAM). This protein is expressed on basolateral cell surface in most simple epithelia and vast majority of cancers. According to the “Cancer Stem Cells” (CSC) theory, tumors are not viewed as simple monoclonal expression of transformed cells, but rather as complex tissue where abnormal growth is driven by a minority pathological CSC pool that on one hand has acquired tumor related features such as uncontrolled growth and ability to form metasis and on the other hand maintains its inherent capacity to self renew and differentiate into a phenotypic ally heterogeneous, although aberrant progency. This antibody has been used recently to characterize the EpCAM high CD44+ versus EpCAM low/Cd44- indifferent cancer cells.

Format

Purified by Protein A Chromatography

Concentration

0.5 mg/mL

Clonality

Monoclonal

Clone

ESA 214

Isotype

IgG1

Applications

ICC, IHC

Host Species

Mouse

Gene Name

EPCAM

Molecular Weight

40 kDa

Antigen

Small cell lung carcinoma

Species Reactivity

Human

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL594 Ex: 594 nm, Em: 615 nm

Specificity

No cross-reactivity reported

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used in Western blot.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Ep-CAM; GA733-2; M1S2; M4S1; MIC18; TACSTD1; TROP1

UniProt Details

UniProt (Human): P16422
UniProt (Immunogen Species): P16422

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Anti-Epithelial Cell Adhesion Molecule (Ep-CAM) Antibody FL594 Conjugate (ESA 214)

SKU: MM-1014-FL594

Product Details

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