Anti-Pan-Kvbeta K+ Channel Antibody (K40/17)

Name: Anti-Pan-Kvbeta K+ Channel Antibody
Brand: NeuroMab
SKU: 75-106
Price: 319.0 USD
Availability: InStock

3 Citations

Our Anti-Pan-Kvbeta K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K40/17. It detects human, mouse, and rat Pan-Kvbeta K+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.

$Immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] and probed with K40/17 (left) or N52A/42 (right) TC supe.$

Immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] and probed with K40/17 (left) or N52A/42 (right) TC supe.

Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC, WB

Host Species

Mouse

Available Conjugates

490

550

594

650

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Data Sheet

SKU: 75-106

Product Details

Target

Pan-Kvbeta K+ channel

Target Description

The ß subunits of voltage-gated potassium channels are members of the potassium channel, voltage-gated, shaker-related subfamily. Kvβs are cytoplasmic subunits that modulate the characteristics of the membrane spanning, channel-forming alpha-subunits. Beta subunits can promote the closure of channels or enhance channel activity depending on other channel proteins. There are three ß subunits (Kvß1, Kvß2, Kvß3) which are coded by three different genes. Additionally, there is alternative splicing of these three genes, further diversifying the functions and tissue expression of the family.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

K40/17

Isotype

IgG2a

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Kcnab1 Kvb1 Kcnab3 Ckbeta3 Kcnab2 Ckbeta2 Kcnb3

Molecular Weight

30-45 kDa

Antigen

Fusion protein amino acids 1-401 (full-length) of rat Kv1 (accession number P63144) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2131361

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.34

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Voltage-gated potassium channel subunit beta-1 (EC 1.1.1.-) (K(+) channel subunit beta-1) (Kv-beta-1) Voltage-gated potassium channel subunit beta-3 (K(+) channel subunit beta-3) (Kv-beta-3) (RCK beta3) Voltage-gated potassium channel subunit beta-2 (EC 1.1.1.-) (K(+) channel subunit beta-2) (Kv-beta-2)

UniProt Details

UniProt (Human): Q14722
UniProt (Immunogen Species): P63144

Product Specific References for Applications and Species

Western Blot: Mouse | Rat

Western Blot: Mouse
PMID	Dilution	Publication
31028120	not listed	Dong, et al. 2019. Dlg1 maintains dendritic cell function by securing voltage-gated K+ channel integrity. . The Journal of Immunology, 3187-3197.
21900579	not listed	Shakkottai VG, et al. 2011. Early changes in cerebellar physiology accompany motor dysfunction in the polyglutamine disease spinocerebellar ataxia type 3.. Journal of Neuroscience, 13002-13014.

Western Blot: Rat
PMID	Dilution	Publication
28673977	not listed	Seagar, et al. 2017. LGI1 tunes intrinsic excitability by regulating the density of axonal Kv1 channels. Proceedings of the National Academy of Sciences, 114(29), pp.7719-7724.. Proceedings of the National Academy of Sciences, 7719-7724.

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Anti-Pan-Kvbeta K+ Channel Antibody (K40/17)

SKU: 75-106

Product Details

Product Specific References for Applications and Species

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