Anti-Thyroid Hormone Receptor Beta1 Antibody (N402/46)

Name: Anti-Thyroid Hormone Receptor Beta1 Antibody
Brand: NeuroMab
SKU: 75-387
Price: 319.0 USD
Availability: InStock

Our Anti-Thyroid hormone receptor beta1 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N402/46. It detects human, mouse, and rat Thyroid hormone receptor beta1, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.

Immunoblot against extracts of COS cells transiently transfected with Myc-tagged TRalpha1, Myc-tagged TRbeta1, Myc-tagged TRbeta2 or untagged Kv2.1 plasmid probed with N402/46 (left) or 19E10 (right) TC supe.

Adult rat brain low-speed pellet immunoblot.

Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC, WB

Host Species

Mouse

Available Conjugates

490

550

594

650

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Data Sheet

SKU: 75-387

Product Details

Target

Thyroid hormone receptor beta1

Target Description

Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005; Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRα1, TRα2, TRβ1 and TRβ2. TRα1, TRβ1 and TRβ2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005).

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N402/46

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

THRB ERBA2 NR1A2 THR1

Molecular Weight

60 kDa

Antigen

Fusion protein amino acids 1-461 (full-length) of human Thyroid hormone receptor beta1 (accession number P10828) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2491092

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

Does not cross-react with Thyroid hormone receptor beta2 or alpha1

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Thyroid hormone receptor beta (Nuclear receptor subfamily 1 group A member 2) (c-erbA-2) (c-erbA-beta)

UniProt Details

UniProt (Human): P10828
UniProt (Immunogen Species): P10828

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Anti-Thyroid Hormone Receptor Beta1 Antibody (N402/46)

SKU: 75-387

Product Details

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