Our Anti-Thyroid hormone receptor beta1 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N402/46. It detects human, mouse, and rat Thyroid hormone receptor beta1, and is purified by Protein A chromatography. It is great for use in IHC, ICC.
Thyroid hormones are essential for development of the central nervous system and deficits in these hormones during development affects such cognitive functions as learning and memory (Ambrogini et al., 2005; Chan and Kilby, 2000). Thyroid hormones exert their physiological role mainly through binding to specific nuclear receptors including the predominant isoforms of thyroid hormone receptors TRα1, TRα2, TRβ1 and TRβ2. TRα1, TRβ1 and TRβ2 bind T3 with high affinity and also bind to thyroid hormone response elements (TREs) on chromatin to regulate the transcriptional processes in several target tissues, including adult rat brain (Constantinou et al., 2005).
Purified by Protein A chromatography
0.5 mg/mL
Monoclonal
N402/46
IgG1
ICC, IHC
Mouse
THRB ERBA2 NR1A2 THR1
60 kDa
Fusion protein amino acids 1-461 (full-length) of human Thyroid hormone receptor beta1 (accession number P10828) produced recombinantly in E. Coli
Human, Mouse, Rat
AB_2940276
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.
PBS with 0.09% azide
FL490 Ex: 491 nm, Em: 515 nm
Does not cross-react with Thyroid hormone receptor beta2 or alpha1
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
United States
12 months from date of receipt
Shipped on ice packs
Thyroid hormone receptor beta (Nuclear receptor subfamily 1 group A member 2) (c-erbA-2) (c-erbA-beta)
