Anti-KChIP4 K+ channel Antibody (N423/75)

5 Citations

Our Anti-KChIP4 K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N423/75. It is KO validated, detects human, mouse, and rat KChIP4 K+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.

Adult rat hippocampus immunohistochemistry.
Adult rat hippocampus immunohistochemistry.
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Adult rat hippocampus immunohistochemistry.
Immunoblot against adult rat brain membranes (RBM) and extracts of COS cells transiently transfected with untagged KChIP1, KChIP2, KChIP3, KChIP4 or Kv2.1 plasmid probed with N423/75 (left) or K55/82 (right) TC supe.
Immunoblot against adult rat brain membranes (RBM) and extracts of COS cells transiently transfected with untagged KChIP1, KChIP2, KChIP3, KChIP4 or Kv2.1 plasmid probed with N423/75 (left) or K55/82 (right) TC supe.

Human, Mouse, Rat
ICC, IHC, WB
Mouse
490
550
594
650
Carrier-Free

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Data Sheet
KO Validated KO Validated

SKU: 75-406

Volume: 100 µL
1-2 business days
Price:
$329.00

Product Details

KChIP4 K+ channel
Potassium voltage-gated channel interacting protein 4 is encoded by the gene KCNIP4. KCNIP4 is a member of the recoverin family. KCNIP4 is a regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels.KCNIP4 modulates KCND2 channel density, inactivation kinetics, and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. KCNIP4 is expressed in brain and bone marrow. Diseases associated with KCNIP4 include Synovial Angioma and Childhood Malignant Schwannoma.
Purified by Protein A chromatography
1 mg/mL
Monoclonal
N423/75
IgG2a
ICC, IHC, WB
Mouse
KCNIP4 CALP KCHIP4
30 kDa
Fusion protein amino acids 1-233 (full-length) of human KChIP4 (accession number Q3YAB7) produced recombinantly in E. Coli.
Human, Mouse, Rat
AB_2493100
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125
WB: 1:1000
IHC: 1:500
Unconjugated
Does not cross-react with KChIP1, KChIP2 or KChIP3
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
United States
24 months from date of receipt
Shipped on ice packs
Kv channel-interacting protein 4 (KChIP4) (A-type potassium channel modulatory protein 4) (Calsenilin-like protein) (Potassium channel-interacting protein 4)
Q3YAB7

Product Specific References for Applications and Species

Immunohistochemistry: Mouse
PMID Dilution Publication
26644354not listedGong, B., et al. 2016. Developing high-quality mouse monoclonal antibodies for neuroscience research - approaches, perspectives and opportunities. New Biotechnology, 551-564.
Immunohistochemistry: Rat
PMID Dilution Publication
32899153not listedAlfaro-Ruíz, R., et al. 2020. Cellular and subcellular localisation of kv4-associated kchip proteins in the rat cerebellum. . International journal of molecular sciences, 6403.
324908111:400Oláh, V.J., et al. 2020. Functional specification of CCK+ interneurons by alternative isoforms of Kv4. 3 auxiliary subunits. . Elife, e58515.
26644354not listedGong, B., et al. 2016. Developing high-quality mouse monoclonal antibodies for neuroscience research - approaches, perspectives and opportunities. New Biotechnology, 551-564.
26239200not listedCheng, C.F., et al. 2016. Coexpression of auxiliary subunits KChIP and DPPL in potassium channel Kv4-positive nociceptors and pain-modulating spinal interneurons.. Journal of Comparative Neurology, 846-873.
Western Blot: Mouse
PMID Dilution Publication
26644354not listedGong, B., et al. 2016. Developing high-quality mouse monoclonal antibodies for neuroscience research - approaches, perspectives and opportunities. New Biotechnology, 551-564.
Western Blot: Rat
PMID Dilution Publication
26644354not listedGong, B., et al. 2016. Developing high-quality mouse monoclonal antibodies for neuroscience research - approaches, perspectives and opportunities. New Biotechnology, 551-564.
26239200not listedCheng, C.F., et al. 2016. Coexpression of auxiliary subunits KChIP and DPPL in potassium channel Kv4-positive nociceptors and pain-modulating spinal interneurons.. Journal of Comparative Neurology, 846-873.

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