Anti-Kv8.2 Potassium Channel Antibody (N448/88)

Name: Anti-Kv8.2 Potassium Channel Antibody
Brand: NeuroMab
SKU: 75-435
Price: 319.0 USD
Availability: InStock

2 Citations

Our Anti-Kv8.2 potassium channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N448/88. It detects mouse Kv8.2 potassium channel, and is purified by Protein A chromatography. It is great for use in ICC, WB.

$Immunoblot against membrane fractions from adult rat brain (RBM) and heart (RHM) and Kcnv2-S2 mouse wild-type (+/+) and higher-expressing transgenic (Tg/+) brains probed with N448/88 (left) and N52A/42 (right) TC supe. Mouse brain samples courtesy of Jennifer Kearney (Northwestern).$

Immunoblot against membrane fractions from adult rat brain (RBM) and heart (RHM) and Kcnv2-S2 mouse wild-type (+/+) and higher-expressing transgenic (Tg/+) brains probed with N448/88 (left) and N52A/42 (right) TC supe. Mouse brain samples courtesy of Jennifer Kearney (Northwestern).

Species Reactivity

Mouse

Applications

ICC, IHC, WB

Host Species

Mouse

Available Conjugates

490

550

594

650

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Data Sheet

SKU: 75-435

Product Details

Target

Kv8.2 potassium channel

Target Description

Voltage-gated K+ channels are important determinants of neuronal membrane excitability (Pongs, 1999). Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types. Members of the Kv5-Kv11 families code for “silent subunits” that do not express as functional homomultimers. In heterologous expression systems, silent subunits can coassemble with Kv2 and Kv3 subunits and modulate the biophysical characteristics of the latter subunits (Yan L. et al., 2004).

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N448/88

Isotype

IgG2b

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Kcnv2

Molecular Weight

65 kDa

Antigen

Fusion protein amino acids 1-163 (cytoplasmic N-terminus) of mouse Kv8.2 (accession number Q8CFS6) produced recombinantly in E. Coli

Species Reactivity

Mouse

Antibody Registry ID

AB_2651161

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Dilution Ranges

IHC: 1:1000
ICC: 1:1000

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Potassium voltage-gated channel subfamily V member 2 (Voltage-gated potassium channel subunit Kv8.2)

UniProt Details

UniProt (Human): Q8TDN2
UniProt (Immunogen Species): Q8CFS6

Product Specific References for Applications and Species

Immunocytochemistry: Mouse
Immunohistochemistry: Mouse

Immunocytochemistry: Mouse
PMID	Dilution	Publication
29483285	1:2 (supe)	Gayet-Primo, J., et al. 2018. Heteromeric KV2/KV8. 2 channels mediate delayed rectifier potassium currents in primate photoreceptors. . Journal of Neuroscience, 3414-3427.

Immunohistochemistry: Mouse
PMID	Dilution	Publication
34652420	1:1000	Inamdar, S.M., et al. 2022. Differential impact of Kv8.2 loss on rod and cone signaling and degeneration. Human Molecular Genetics, 1035-1050.

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Anti-Kv8.2 Potassium Channel Antibody (N448/88)

SKU: 75-435

Product Details

Product Specific References for Applications and Species

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