Anti-Kv1.2 K+ Channel Antibody (K14/16)

Name: Anti-Kv1.2 K+ Channel Antibody
Brand: NeuroMab
SKU: 75-008
Price: 374.0 USD
Availability: InStock

193 Citations

Our Anti-Kv1.2 K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K14/16. It is KO validated, detects human, mouse, and rat Kv1.2 K+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB.

Immunolabeling of postnatal 14 mouse CA3 (Axonal Initial Segment, Parvalbumin positive interneuron) labeling Kv1.2 (75-008, 1:200, yellow) Parvalbumin (magenta), and Ankyrin G (cyan). Mice were transcardially perfused with cold 4% PFA in PBS, then brain removed and postfixed overnight. 50 uM slices as floating sections, antigen retrieval performed with sodium citrate at 80 C for 30 min. before immunolabeling. Images from J. Ramirez-Franco and O. El Far, Aix-Marseille Université and INSERM.

Immunolabeling of permeabilized HEK293 cells specifically labeling intracellular Kv1.2 (Cat no 75-008, 1:200, red) and DAPI labelling DNA (blue). Images kindly provided by Ivan Talucci and Maric Hans, Rudolf Virchow Center for Integrative and Translational Bioimaging.

Immunoblot on brain membranes from wild-type (WT) and Kv1.2 knockout (Kv1.2-/-) mice and from adult rat brain (RBM).

Immunolabeling of permeabilized mouse teased fibers, where in red is the juxta-paranodal staining for Kv1.2 (Cat no 75-008, 1:200, red). Murine sciatic nerves were dissected from hind limbs, fixed in 4% paraformaldehyde, and washed in PBS. The epineurium was removed prior to teasing. Teased fibers were air-dried and stored at −20°C until further usage. Obj. 63x, scale bar = 10um. Images kindly provided by Ivan Talucci and Maric Hans, Rudolf Virchow Center for Integrative and Translational Bioimaging.

Adult rat hippocampus immunohistochemistry.

Immunoblot on membranes from whole rat (RBM) and mouse (MBM) brain and from human cerebral cortex [HBM(Cx)] and hippocampus [HBM(H)].

Immunofluorescence showing labeling of CASPR (red) and Kv1.2(green) in the spinal cord of P21 Shank3(+ / +) and Shank3Δ11(−/−) mice. Image from publication CC-BY-4.0. PMID: 35726031

Left, 63× images of Kv1.2 immunoreactivity at CA3 Axonal Initial segments in WT (top panels) and Lgi1−/− (bottom panels). Scale bar = 10 μm. Right, detail of a CA3 pyramidal neuron AIS in WT (top panels) and Lgi1−/− (bottom panels).

63× images showing no differences in Kv1.2 IR at the AIS of PV+ interneurons. Scale bar = 10 μm (G) Cumulative probability plots of Kv1.2 immunoreactivity at individual AIS of WT (black squares) and Lgi1−/− (red circles) CA3 pyramidal neurons

Immunolabeling of postnatal 14 mouse CA3 (Axonal Initial Segment, Parvalbumin positive interneuron) labeling Kv1.2 (75-008, 1:200, yellow) Parvalbumin (magenta), and Ankyrin G (cyan). Mice were transcardially perfused with cold 4% PFA in PBS, then brain removed and postfixed overnight. 50 uM slices as floating sections, antigen retrieval performed with sodium citrate at 80 C for 30 min. before immunolabeling. Images from J. Ramirez-Franco and O. El Far, Aix-Marseille Université and INSERM.

Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC, IP, WB

Host Species

Mouse

Available Conjugates

490

550

594

650

Go to Full Product Details

Data Sheet

KO Validated

Trial Size

SKU: 75-008

Volume: 100 µL

Variant

Price:

$374.00

Quantity:

Product Details

Target

Kv1.2 K+ channel

Target Description

Kv1.2 K+ channel (Potassium voltage-gated channel subfamily A member 2), which is encoded by KCNA2 gene, is part of the Potassium voltage-gated channel family. Kv1.2 K+ channel switches between its open and closed conformation in response to the voltage difference across the membrane, which selectively allows the traffic of K+. Kv1.2 K+ channel determines potassium ion permeability of excitable membranes according to their electrochemical gradient. Therefore, this protein has for function to regulate neurotransmitter release, neuronal excitability, smooth muscle contraction, heart muscle contraction or insulin secretion. Kv1.2 is recognized as a tansmembrane/ multi-pass membrane protein. Anti-Kv1.2 K+ channel K14/16 is often used in IHC on human normal cerebral cortex.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

K14/16

Isotype

IgG2b

Applications

ICC, IHC, IP, WB

Host Species

Mouse

Gene Name

KCNA2

Molecular Weight

80 kDa

Antigen

Fusion protein amino acids 428-499(cytoplasmic C-terminus) of rat Kv1.2 (accession number P63142) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2296313

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4

Dilution Ranges

WB: 1:1000
IHC: 1:250
ICC: 1:250

Conjugate

Unconjugated

Specificity

No cross-reactivity against Kv1.1, Kv1.3, Kv1.4, Kv1.5 and Kv1.6 expressed in transfected cells

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Potassium voltage-gated channel subfamily A member 2 (NGK1) (Voltage-gated K(+) channel HuKIV) (Voltage-gated potassium channel HBK5) (Voltage-gated potassium channel subunit Kv1.2)

UniProt Details

UniProt (Human): P16389
UniProt (Immunogen Species): P16389

Product Specific References for Applications and Species

ELISA: Mouse
Gene Expression Assay: Mouse
Immunocytochemistry: Human | Mouse | Rat
Immunohistochemistry: Gerbil | Human | Mouse | Non-Human Primate | Rat
Western Blot: Human | Mouse | Rat
Additional Publications: Unspecified

ELISA: Mouse
PMID	Dilution	Publication
38663634	not listed	Ramirez-Franco, J, et al. 2024. The downregulation of Kv1 channels in Lgi1-/-mice is accompanied by a profound modification of its interactome and a parallel decrease in Kv2 channels. Neurobiology of Disease, 106513.

Gene Expression Assay: Mouse
PMID	Dilution	Publication
28673977	not listed	Seagar, M., et al. 2017. LGI1 tunes intrinsic excitability by regulating the density of axonal Kv1 channels. PNAS, 7719-24.

Immunocytochemistry: Human
PMID	Dilution	Publication
38665908	1:200	Talucci, I, et al. 2024. Molecular dissection of an immunodominant epitope in Kv1.2-exclusive autoimmunity. Frontiers in Immunology, 1329013.

Immunocytochemistry: Mouse
PMID	Dilution	Publication
31164806	not listed	Bonetto, G., et al. 2019. Selective axonal expression of the Kv1 channel complex in pre-myelinated GABAergic hippocampal neurons. Frontiers in Cellular Neuroscience, 222.
30224722	1:500	Yang, Y.M., et al. 2018. Identification of a molecular locus for normalizing dysregulated GABA release from interneurons in the Fragile X brain.. Molecular Psychiatry, 2017-35.
29429934	not listed	Dawes, J.M., et al. 2018. Immune or genetic-mediated disruption of CASPR2 causes pain hypersensitivity due to enhanced primary afferent excitability. . Neuron, 806-822.
29138759	not listed	Browne, L., et al. 2017. Identification of Persistent and Resurgent Sodium Currents in Spiral Ganglion Neurons Cultured from the Mouse Cochlea.. eNeuro, ENEURO.0303-17.2017.
28331203	1:100	Rama, S., et al. 2017. The role of axonal Kv1 channels in CA3 pyramidal cell excitability. Scientific Reports, 315.
25362471	not listed	Chang, K.J., et al. 2014. Glial ankyrins facilitate paranodal axoglial junction assembly.. Nature Neuroscience, 1673-81.
24412576	not listed	Barry, J., et al. 2014. Ankyrin-G directly binds to kinesin-1 to transport voltage-gated Na+ channels into axons.. Developmental Cell, 117-31.
24011083	1:200	Green, J.A., et al. 2014. Whirlin, a cytoskeletal scaffolding protein, stabilizes the paranodal region and axonal cytoskeleton in myelinated axons.. BMC Neuroscience, 96.

Immunocytochemistry: Rat
PMID	Dilution	Publication
33185190	1:100	Sanders, S.S., et al. 2020. The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment. eLife, e56058.
31176559	1:100	Saint-Martin, M., et al. 2019. Impact of anti-CASPR2 autoantibodies from patients with autoimmune encephalitis on CASPR2/TAG-1 interaction and Kv1 expression. Journal of Autoimmunity, 102284.
30598502	not listed	Hivert, B., et al. 2019. ADAM22 and ADAM23 modulate the targeting of the Kv1 channel-associated protein LGI1 to the axon initial segment. . Journal of Cell Science, jcs219774.

Immunohistochemistry: Gerbil
PMID	Dilution	Publication
38174817	1:500	Nabel, A.L., et al. 2024. Development of myelination and axon diameter for fast and precise action potential conductance. Glia, 794-808.

Immunohistochemistry: Human
PMID	Dilution	Publication
38309639	1:200	Arlt, FA, et al. 2024. KCNA2 IgG autoimmunity in neuropsychiatric diseases. Brain, behavior, and immunity, 399-411.
37862170	not listed	Chang, C, et al. 2023. Mouse models of human CNTNAP1-associated congenital hypomyelinating neuropathy and genetic restoration of murine neurological deficits. Cell Reports, 113274.
33315860	1:100	Gallego-Delgado, P., et al. 2020. Neuroinflammation in the normal-appearing white matter (NAWM) of the multiple sclerosis brain causes abnormalities at the nodes of Ranvier. PLoS Biology, e3001008.
29564531	not listed	Willis, M., et al. 2018. Shaker-related voltage-gated potassium channels Kv1 in human hippocampus. Brain Structure and Function, 2663-71.
28115470	not listed	Lang, B., et al. 2017. Intracellular and non-neuronal targets of voltage-gated potassium channel complex antibodies. Journal of Neurology, Neurosurgery, and Psychiatry, 353-61.

Immunohistochemistry: Mouse
PMID	Dilution	Publication
39142424	1:200	van Hoof, S., et al. 2024. Human cerebrospinal fluid monoclonal CASPR2 autoantibodies induce changes in electrophysiology, functional MRI, and behavior in rodent models. Brain, Behavior, and Immunity, 266-278.
39103318	1:500	Han, X., et al. 2024. Multiplexed volumetric CLEM enabled by scFvs provides insights into the cytology of cerebellar cortex. Nature Communications, 6648.
38663634	not listed	Ramirez-Franco, J, et al. 2024. The downregulation of Kv1 channels in Lgi1-/-mice is accompanied by a profound modification of its interactome and a parallel decrease in Kv2 channels. Neurobiology of Disease, 106513.
38309639	1:200	Arlt, FA, et al. 2024. KCNA2 IgG autoimmunity in neuropsychiatric diseases. Brain, behavior, and immunity, 399-411.
38277269	1:250	Sell, LB, et al. 2024. Protocol for isolating and processing mouse sciatic nerve fibers for confocal immunohistochemistry. STAR protocols, 102852.
38194969	not listed	Miyazaki, Y, et al. 2024. Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity. Cell Reports, 113634.
37607607	1:300	Liang, Y, et al. 2023. Transcription factor EBF1 mitigates neuropathic pain by rescuing Kv1.2 expression in primary sensory neurons. Translational research : the journal of laboratory and clinical medicine, .
36640913	1:500	Otuyemi, B., et al. 2023. Domain and Cell Type-specific Immunolocalisation of Voltage-gated Potassium Channels in the Mouse Striatum. Journal of Chemical Neuroanatomy, 102233.
36631269	1:500	Zhang, X., et al. 2023. Anti-LGI4 Antibody Is a Novel Juxtaparanodal Autoantibody for Chronic Inflammatory Demyelinating Polyneuropathy. Neurology Neuroimmunology & Neuroinflammation, e200081.
35726031	1:200	Malara, M., et al. 2022. SHANK3 Deficiency Leads to Myelin Defects in the Central and Peripheral Nervous System. Cellular and Molecular Life Sciences, 371.
35501931	not listed	Radomski, K.L., et al. 2022. Acute axon damage and demyelination are mitigated by 4-aminopyridine (4-AP) therapy after experimental traumatic brain injury. Acta Neuropathologica Communications, 67.
33397712	not listed	Sukhanov, N., et al. 2021. Differential Contribution of Cadm1–Cadm3 Cell Adhesion Molecules to Peripheral Myelinated Axons. Journal of Neuroscience, 1393-1400.
32142125	not listed	Kawamura, A., et al. 2020. Oligodendrocyte dysfunction due to Chd8 mutation gives rise to behavioral deficits in mice. Human Molecular Genetics, 1274-91.
32052742	1:500	Liu, C.H., et al. 2020. Nodal β spectrins are required to maintain Na + channel clustering and axon integrity. eLife, e52378.
31248728	1:250	Zheng, Y., et al. 2019. Deep sequencing of somatosensory neurons reveals molecular determinants of intrinsic physiological properties. . Neuron, 598-616.
31164806	not listed	Bonetto, G., et al. 2019. Selective axonal expression of the Kv1 channel complex in pre-myelinated GABAergic hippocampal neurons. Frontiers in Cellular Neuroscience, 222.
30447021	1:200	Saifetiarova, J., et al. 2019. Ablation of Cytoskeletal Scaffolding Proteins, Band 4.1B and Whirlin, Leads to Cerebellar Purkinje Axon Pathology and Motor Dysfunction. Journal of Neuroscience Research, 313-31.
29300891	1:400	Scott, R., et al. 2019. Loss of Cntnap2 Causes Axonal Excitability Deficits, Developmental Delay in Cortical Myelination, and Abnormal Stereotyped Motor Behavior. Cerebral Cortex, 586-597.
30356053	1:10,000	Baronas, V., et al. 2018. Slc7a5 regulates Kv1.2 channels and modifies functional outcomes of epilepsy-linked channel mutations. Nature Communications, 4417.
29963618	not listed	Taylor, A., et al. 2018. Simultaneous Ablation of Neuronal Neurofascin and Ankyrin G in Young and Adult Mice Reveals Age-Dependent Increase in Nodal Stability in Myelinated Axons and Differential Effects on the Lifespan. eNeuro, ENEURO.0138-18.2018.
29853631	not listed	Susuki, K., et al. 2018. Glial βII Spectrin Contributes to Paranode Formation and Maintenance. Journal of Neuroscience, 6063-75.
29673258	not listed	Griggs, R., et al. 2018. Methylglyoxal Disrupts Paranodal Axoglial Junctions via Calpain Activation. ASN Neuro, 1759091418766170.
29491011	1:500	Zhou, L., et al. 2018. Celecoxib ameliorates seizure susceptibility in autosomal dominant lateral temporal epilepsy. The Journal of Neuroscience, 3346-57.
29038243	not listed	Huang, C., et al. 2017. An αII Spectrin-Based Cytoskeleton Protects Large-Diameter Myelinated Axons from Degeneration. Journal of Neuroscience, 11323-11334.
29038240	not listed	Huang, C., et al. 2017. αII Spectrin Forms a Periodic Cytoskeleton at the Axon Initial Segment and Is Required for Nervous System Function. Journal of Neuroscience, 11311-22.
28559325	1:500	Stange-Marten, A., et al. 2017. Input timing for spatial processing is precisely tuned via constant synaptic delays and myelination patterns in the auditory brainstem.. Proceedings of the National Academy of Science of the United States of America, E4851-8.
28370195	not listed	Saifetiarova, J., et al. 2017. Axonal Domain Disorganization in Caspr1 and Caspr2 Mutant Myelinated Axons Affects Neuromuscular Junction Integrity Leading to Muscle Atrophy. Journal of Neuroscience Research, 1373-90.
28322742	1:100	Maglemose, R., et al. 2017. Potassium channel abnormalities are consistent with early axon degeneration of motor axons in the G127X SOD1 mouse model of amyotrophic lateral sclerosis. Experimental Neurology, 154-167.
28270689	1:200	Zhao, J.Y., et al. 2017. DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons. Nature communications, 8(1), pp.1-15.. Nature communications, 44576.
28217083	1:200	Taylor, A., et al. 2017. Postnatal Loss of Neuronal and Glial Neurofascins Differentially Affects Node of Ranvier Maintenance and Myelinated Axon Function. Frontiers in Cellular Neuroscience, 11.
28148727	not listed	Saifetiarova, J., et al. 2017. Early and Late Loss of the Cytoskeletal Scaffolding Protein, Ankyrin G Reveals Its Role in Maturation and Maintenance of Nodes of Ranvier in Myelinated Axons. Journal of Neuroscience, 2524-38.

Immunohistochemistry: Non-Human Primate
PMID	Dilution	Publication
38309639	1:200	Arlt, FA, et al. 2024. KCNA2 IgG autoimmunity in neuropsychiatric diseases. Brain, behavior, and immunity, 399-411.

Immunohistochemistry: Rat
PMID	Dilution	Publication
38309639	1:200	Arlt, FA, et al. 2024. KCNA2 IgG autoimmunity in neuropsychiatric diseases. Brain, behavior, and immunity, 399-411.
36050224	1:200	Sharma, K., et al. 2022. Low-Voltage Activating K+ Channels in Cochlear Afferent Nerve Fiber Dendrites. Experimental Neurobiology, 243-259.
30356053	1:10,000	Baronas, V., et al. 2018. Slc7a5 regulates Kv1.2 channels and modifies functional outcomes of epilepsy-linked channel mutations. Nature Communications, 4417.
24723263	1:500	Dufour, M.A., et al. 2014. Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development.. Journal of Neuroscience Research, 981-99.

Western Blot: Human
PMID	Dilution	Publication
33803465	1:1000	Zhang, Y., et al. 2021. Regulation of K+ Conductance by a Hydrogen Bond in Kv2.1, Kv2.2, and Kv1.2 Channels. Membranes (Basel), 190.
32311044	1:2000	Lamothe, S., et al. 2020. Slc7a5 alters Kvβ-mediated regulation of Kv1.2. Journal of General Physiology, e201912524.
30593566	1:20,000	Cordeiro, S., et al. 2019. Conotoxin κM-RIIIJ, a tool targeting asymmetric heteromeric Kv1 channels. PNAS, 1059-64.
29564531	not listed	Willis, M., et al. 2018. Shaker-related voltage-gated potassium channels Kv1 in human hippocampus. Brain Structure and Function, 2663-71.
28432329	not listed	Desplantes, R., et al. 2017. Affinity biosensors using recombinant native membrane proteins displayed on exosomes: Application to botulinum neurotoxin B receptor. Scientific Reports, 1032.

Western Blot: Mouse
PMID	Dilution	Publication
38663634	not listed	Ramirez-Franco, J, et al. 2024. The downregulation of Kv1 channels in Lgi1-/-mice is accompanied by a profound modification of its interactome and a parallel decrease in Kv2 channels. Neurobiology of Disease, 106513.
38194969	not listed	Miyazaki, Y, et al. 2024. Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity. Cell Reports, 113634.
37833406	not listed	Ma, D, et al. 2023. A cytoskeleton-membrane interaction conserved in fast-spiking neurons controls movement, emotion, and memory. Molecular psychiatry, .
34910912	not listed	Yokoi, N., et al. 2021. 14-3-3 proteins stabilize LGI1-ADAM22 levels to regulate seizure thresholds in mice. Cell Reports, 110107.
33157003	not listed	Kuijpers, M., et al. 2021. Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum. Neuron, 299-313.e9.
31017573	1:500	Carrillo-Reid, L., et al. 2019. Mutant huntingtin enhances activation of dendritic Kv4 K+ channels in striatal spiny projection neurons. eLife, e40818.
30684388	1:500	Mao, Q., et al. 2019. DNMT3a-triggered downregulation of K2p1.1 gene in primary sensory neurons contributes to paclitaxel-induced neuropathic pain. International Journal of Cancer, 2122-34.
30447021	1:1000	Saifetiarova, J., et al. 2019. Ablation of Cytoskeletal Scaffolding Proteins, Band 4.1B and Whirlin, Leads to Cerebellar Purkinje Axon Pathology and Motor Dysfunction. Journal of Neuroscience Research, 313-31.
30356053	1:10,000	Baronas, V., et al. 2018. Slc7a5 regulates Kv1.2 channels and modifies functional outcomes of epilepsy-linked channel mutations. Nature Communications, 4417.
30224722	1:500	Yang, Y.M., et al. 2018. Identification of a molecular locus for normalizing dysregulated GABA release from interneurons in the Fragile X brain.. Molecular Psychiatry, 2017-35.
29963618	not listed	Taylor, A., et al. 2018. Simultaneous Ablation of Neuronal Neurofascin and Ankyrin G in Young and Adult Mice Reveals Age-Dependent Increase in Nodal Stability in Myelinated Axons and Differential Effects on the Lifespan. eNeuro, ENEURO.0138-18.2018.
29564531	not listed	Willis, M., et al. 2018. Shaker-related voltage-gated potassium channels Kv1 in human hippocampus. . Brain Structure and Function, 2663-2671.
29491011	1:500	Zhou, L., et al. 2018. Celecoxib ameliorates seizure susceptibility in autosomal dominant lateral temporal epilepsy. The Journal of Neuroscience, 3346-57.
29476105	1:1000	Nguyen, L.H., et al. 2018. mTOR-dependent alterations of Kv1.1 subunit expression in the neuronal subset-specific Pten knockout mouse model of cortical dysplasia with epilepsy. Scientific Reports, 3568.
28270689	1:200	Zhao, J.Y., et al. 2017. DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons. Nature communications, 8(1), pp.1-15.. Nature communications, 44576.
28148727	not listed	Saifetiarova, J., et al. 2017. Early and Late Loss of the Cytoskeletal Scaffolding Protein, Ankyrin G Reveals Its Role in Maturation and Maintenance of Nodes of Ranvier in Myelinated Axons. Journal of Neuroscience, 2524-38.
26406915	1:1000	Brügger, V., et al. 2015. HDAC1/2-Dependent P0 Expression Maintains Paranodal and Nodal Integrity Independently of Myelin Stability through Interactions with Neurofascins.. PLoS Biology, e1002258.
25670860	1:2 (supe)	Nieves-Cintrón, M., et al. 2015. Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes.. The Journal of Biological Chemistry, 7918-29.
25485908	1 : 1000	Yokoi, N., et al. 2015. Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsy.. Nature Medicine, 19-26.
25362471	not listed	Chang, K.J., et al. 2014. Glial ankyrins facilitate paranodal axoglial junction assembly.. Nature Neuroscience, 1673-81.

Western Blot: Rat
PMID	Dilution	Publication
33185190	1:500	Sanders, S.S., et al. 2020. The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment. eLife, e56058.
32634531	1:20,000	Sánchez-Aguilera, A., et al. 2020. Development of Action Potential Waveform in Hippocampal CA1 Pyramidal Neurons. Neuroscience, 151-67.
31176559	1:5000	Saint-Martin, M., et al. 2019. Impact of anti-CASPR2 autoantibodies from patients with autoimmune encephalitis on CASPR2/TAG-1 interaction and Kv1 expression. Journal of Autoimmunity, 102284.
30515739	1:1000	Wu, Q., et al. 2019. TET1 Overexpression Mitigates Neuropathic Pain Through Rescuing the Expression of μ-Opioid Receptor and Kv1.2 in the Primary Sensory Neurons. Neurotherapeutics, 491-504.
30356053	1:10,000	Baronas, V., et al. 2018. Slc7a5 regulates Kv1.2 channels and modifies functional outcomes of epilepsy-linked channel mutations. Nature Communications, 4417.
29056068	1:200	Miao, X., et al. 2017. DNMT3a contributes to the development and maintenance of bone cancer pain by silencing Kv1.2 expression in spinal cord dorsal horn. Molecular Pain, 1744806917740680.
22675541	not listed	Manning, C.F., et al. 2012. Benefits and pitfalls of secondary antibodies: why choosing the right secondary is of primary importance.. PLoS One, e38313.

Additional Publications: Unspecified
PMID	Publication
27615452	Schneider, S., et al. 2016. Decrease in newly generated oligodendrocytes leads to motor dysfunctions and changed myelin structures that can be rescued by transplanted cells. Glia, 2201-18.
27168396	Berret, E., et al. 2016. Functional and structural properties of ion channels at the nerve terminal depends on compact myelin. Journal of Physiology, 5593-5609.
26949968	Chihabi, K., et al. 2016. Intra-cerebellar infusion of the protein kinase Mzeta (PKMζ) inhibitor ZIP disrupts eyeblink classical conditioning. Behavioral Neuroscience, 563-71.
26840208	Hivert, B., et al. 2016. Assembly of juxtaparanodes in myelinating DRG culture: Differential clustering of the Kv1/Caspr2 complex and scaffolding protein 4.1B.. Glia, 840-52.
26763782	Rash, J., et al. 2016. KV1 channels identified in rodent myelinated axons, linked to Cx29 in innermost myelin: support for electrically active myelin in mammalian saltatory conduction. Journal of Neurophysiology, 1836-59.
26646078	Baronas, V.A., et al. 2016. Determinants of frequency-dependent regulation of Kv1.2-containing potassium channels.. Channels (Austin)., 158-66.
26240432	Peltola, M.A., et al. 2016. AMIGO-Kv2.1 Potassium Channel Complex Is Associated With Schizophrenia-Related Phenotypes.. Schizophrenia Bulletin, 191-201.
26342649	Wang, P., et al. 2015. Short-Term Sleep Disturbance-Induced Stress Does not Affect Basal Pain Perception, but Does Delay Postsurgical Pain Recovery. Journal of Pain, 1186-99.
26305015	Ford, M.C., et al. 2015. Tuning of Ranvier node and internode properties in myelinated axons to adjust action potential timing.. Nature Communications, 8073.
26269648	Kole, M.J., et al. 2015. Selective Loss of Presynaptic Potassium Channel Clusters at the Cerebellar Basket Cell Terminal Pinceau in Adam11 Mutants Reveals Their Role in Ephaptic Control of Purkinje Cell Firing.. Journal of Neuroscience, 11433-44.
26269632	Smith, K., et al. 2015. Phosphoinositide Modulation of Heteromeric Kv1 Channels Adjusts Output of Spiral Ganglion Neurons from Hearing Mice. Journal of Neuroscience, 11221-32.
26226133	van Vliet, A.C., et al. 2015. Human Neuroma-in-Continuity Contains Focal Deficits in Myelination. Journal of Neuropathology & Experimental Neurology, 901-11.
25846372	Yoo, S.W., et al. 2015. Sialylation regulates brain structure and function.. The FASEB Journal, 3040-53.
25751627	Syrbe, S., et al. 2015. De novo loss- or gain-of-function mutations in KCNA2 cause epileptic encephalopathy.. Nature Genetics, 393-9.
25716850	Baronas, V.A., et al. 2015. Use-dependent activation of neuronal Kv1.2 channel complexes.. Journal of Neuroscience, 3515-24.
25413837	Miyazaki, H., et al. 2014. Singular localization of sodium channel β4 subunit in unmyelinated fibres and its role in the striatum.. Nature Communications, 5525.
25119334	Salewski, R.P., et al. 2014. Transplantation of neural stem cells clonally derived from embryonic stem cells promotes recovery after murine spinal cord injury.. Stem Cells and Development, 36-50.
24849898	Zenker, J., et al. 2014. A role of peripheral myelin protein 2 in lipid homeostasis of myelinating Schwann cells.. Glia, 1502-12.
24723263	Dufour, M.A., et al. 2014. Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development.. Journal of Neuroscience Research, 981-99.
24719114	Lehnert, S., et al. 2014. Action potential generation in an anatomically constrained model of medial superior olive axons.. Journal of Neuroscience, 5370-84.
24631676	Kim, K.Y., et al. 2014. Localization and expression of CaBP1/caldendrin in the mouse brain.. Neuroscience, 33-47.
24498366	Bagchi, B., et al. 2014. Disruption of myelin leads to ectopic expression of K(V)1.1 channels with abnormal conductivity of optic nerve axons in a cuprizone-induced model of demyelination.. PLoS One, e87736.
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Anti-Kv1.2 K+ Channel Antibody (K14/16)

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