Our Anti-GAP43 primary antibody from PhosphoSolutions is chicken polyclonal. It detects bovine, horse, human, mouse, and rat GAP43 and is total IgY fraction. It is great for use in WB, IHC, ICC.
Western blot of rat cortical lysate showing specific immunolabeling of the ~43 kDa GAP43 protein.
GAP-43 is thought to have an important role in development and plasticity because it is expressed at high levels in neuronal growth cones during development and during axonal regeneration (Benowitz and Routtenberg, 1997). There is also evidence from knockout animals that GAP-43 serves to amplify pathfinding signals from the growth cone (Strittmatter et al., 1995). GAP-43 is thought to mediate at least some of these effects via interaction with actin. Importantly, phosphorylation at Ser-41 by protein kinase C modulates the interaction of GAP-43 with actin (He et al., 1997) and may also affect neurotransmitter release during forms of plasticity like LTP (Hulo et al., 2002).
Total IgY fraction
Polyclonal
IgY
ICC, IHC, WB
Chicken
GAP43
43 kDa
Synthetic peptide corresponding to amino acid residues from the C-terminal region of rat GAP43, conjugated to keyhole limpet hemocyanin (KLH).
Human, Mouse, Rat
AB_2492122
Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.
Specific for endogenous levels of the ~43 kDa GAP-43 protein.
Western blots performed on each lot.
For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
After date of receipt, stable for at least 1 year at -20°C.
Blue Ice
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Rodríguez-Prieto, Á, et al. 2024. Nrg1 intracellular signaling regulates the development of interhemispheric callosal axons in mice. Life science alliance, 0.
Rodríguez-Prieto, Á, et al. 2024. Nrg1 intracellular signaling regulates the development of interhemispheric callosal axons in mice. Life science alliance, 0.
Gopalakrishna, R., Gundimeda, U., Schiffman, J.E. and McNeill, T.H., 2008. A direct redox regulation of protein kinase C isoenzymes mediates oxidant-induced neuritogenesis in PC12 cells. Journal of Biological Chemistry, 283(21), pp.14430-14444. PMID: 18375950
Hulo, S., Alberi, S., Laux, T., Muller, D. and Caroni, P., 2002. A point mutant of GAP‐43 induces enhanced short‐term and long‐term hippocampal plasticity. European Journal of Neuroscience, 15(12), pp.1976-1982. PMID: 12099903
Benowitz, L.I. and Routtenberg, A., 1997. GAP-43: an intrinsic determinant of neuronal development and plasticity. Trends in Neurosciences, 20(2), pp.84-91. PMID: 9023877
He, Q., Dent, E.W. and Meiri, K.F., 1997. Modulation of actin filament behavior by GAP-43 (neuromodulin) is dependent on the phosphorylation status of serine 41, the protein kinase C site. Journal of Neuroscience, 17(10), pp.3515-3524. PMID: 9133376
Strittmatter, S.M., Fankhauser, C., Huang, P.L., Mashimo, H. and Fishman, M.C., 1995. Neuronal pathfinding is abnormal in mice lacking the neuronal growth cone protein GAP-43. Cell, 80(3), pp.445-452. PMID: 7859286
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