Anti-Vesicular Monoamine Transporter 2, C-terminus (VMAT2) Antibody

3 Citations

Our Anti-Vesicular Monoamine Transporter 2, C-terminus (VMAT2) sheep polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects rat Vesicular Monoamine Transporter 2, C-terminus (VMAT2) and is antigen affinity purified from pooled serum. It is great for use in WB.

Western blot of rat striatal lysate showing specific immunolabeling of the ~57 kDa VMAT2 protein.
Western blot of rat striatal lysate showing specific immunolabeling of the ~57 kDa VMAT2 protein.
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Western blot of rat striatal lysate showing specific immunolabeling of the ~57 kDa VMAT2 protein.
Immunostaining against ChAT (red) and VMAT2 (Cat no. 2250-VMAT2C, 1:200, green) in retinal sections of control (e) and Parkinson's Desease (f) patients. Image from publication CC-BY-4.0. PMID: 37013599
Retinal sections immunostained against TH (red), ChAT (green) and vesicular monoamine transporter 2 (VMAT2, blue). S1/S2: stratum 1 and 2 in the IPL. S3/S4: stratum 3 and 4 in the IPL. Scale bar: 20 μm. Image from publication CC-BY-4.0. PMID: 37013599

Human, Rat
IHC, WB
Sheep

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Data Sheet
Trial Size Trial Size Pooled Serum Pooled Serum

SKU: 2250-VMAT2C

Volume: 100 µL
Price:
$445.00
Ships: 1-2 business days

Product Details

Vesicular Monoamine Transporter 2, C-terminus (VMAT2)
Vesicular neurotransmitter transporters sequester the transmitters into synaptic vesicles (Erickson et al., 1996). The vesicular monoamine transporter 2 (VMAT2) is responsible for catecholamine and serotonin storage in central synapses. Antibodies specific for VMAT have been used to monitor expression of the transporter during development and in aging and can be effectively used as a marker for monoamine terminals (Haycock et al., 2003; Witkovsky et al., 2005).
Antigen Affinity Purified from Pooled Serum
Polyclonal
IgG
IHC, WB
Sheep
VMAT2
57 kDa
Synthetic peptide corresponding to amino acid residues from the intracellular C-terminal region of human VMAT2, conjugated to keyhole limpet hemocyanin (KLH).
Human, Rat
AB_2492286
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Liquid
Prepared from pooled sheep serum by affinity purification using a column to which the peptide immunogen was coupled.
10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
WB: 1:1000
WB Brain: 1:1000
IHC: 1:200
Unconjugated
Specific for endogenous levels of the ~57 kDa VMAT2 protein.
Western blots performed on each lot.
For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
After date of receipt, stable for at least 1 year at -20°C.
Blue Ice
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Q05940
6571

Product Specific References for Applications and Species

Immunohistochemistry: Human
PMID Dilution Publication
370135991:200Sánchez-Sáez, X., et al. 2023. Starburst amacrine cells, involved in visual motion perception, loose their synaptic input from dopaminergic amacrine cells and degenerate in Parkinson's disease patients. Translational Neurodegeneration, 17.
Immunohistochemistry: Mouse
PMID Dilution Publication
263560101:10,000Ivanova, E., et al. 2016. Disruption in Dopaminergic Innervation During Photoreceptor Degeneration. Journal of Comparative Neurology, .
Western Blot: Rat
PMID Dilution Publication
297298911:1000Colon-Perez, L.M., et al. 2018. Functional Connectivity, Behavioral and Dopaminergic Alterations 24 Hours Following Acute Exposure to Synthetic Bath Salt Drug Methylenedioxypyrovalerone. Neuropharacology, .

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