Anti-Notch 3 Homolog Antibody

Name: Anti-Notch 3 Homolog Antibody
Brand: PhosphoSolutions
SKU: 65101
Price: 430.0 USD
Availability: InStock

Our Notch 3 Homolog rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human Notch 3 Homolog and is antigen affinity purified. It is great for use in WB, IHC.

Immunohistochemistry of 10 micron cryostat sections of rat brain fixed with 4% formaldehyde by transcardial perfusion showing specific staining of Notch 3.

Species Reactivity

Human

Applications

IHC, WB

Host Species

Rabbit

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SKU: 65101

Title: 100 µL

Variant

Price:

$430.00

Quantity:

Product Details

Target

Notch 3 Homolog

Target Description

Notch signaling plays a key role in the normal development of many tissues and cell types, through diverse effects on differentiation, survival, and/or proliferation that are highly dependent on signal strength and cellular context. Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. Notch family members share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Multiple human notch proteins (NOTCH1, NOTCH2, NOTCH3 and NOTCH4) have been identified and they function as a receptors for membrane bound ligands. Notch signaling is also linked to tumorigenesis as first demonstrated by the identification of a recurrent t(7;9)(q34;q34.3) chromosomal translocation involving the human Notch1 gene that is found in a small subset of human pre-T-cell acute lymphoblastic leukemias (T-ALL). Since this discovery, aberrant Notch signaling has been suggested to be involved in a wide variety of human neoplasms. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL).

Format

Antigen Affinity Purified

Clonality

Polyclonal

Isotype

IgG

Applications

IHC, WB

Host Species

Rabbit

Gene Name

NOTCH3

Antigen

Synthetic peptide corresponding to amino acids from the C-terminal region of the human NOTCH homolog 3 (NOTCH3) protein.

Species Reactivity

Human

Storage

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Physical State

Liquid

Buffer

PBS + 0.02% NaN3

Dilution Ranges

WB: 1:500-1:1000
WB Brain: 1:500-1:1000
IHC: 0.2152777777777778

Specificity

Reacts with the C-terminal region of the human NOTCH homolog 3 (NOTCH3) protein.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Shipping

Blue Ice

Synonyms

Neurogenic locus notch homolog protein 3, hN3,

UniProt Details

UniProt (Human): Q9UM47
UniProt (Immunogen Species): Q9UM47

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Anti-Notch 3 Homolog Antibody

SKU: 65101

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