Anti-Tyrosine Hydroxylase Antibody

Our Anti-Tyrosine Hydroxylase rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects all mammalian Tyrosine Hydroxylase and is antigen affinity purified from pooled serum. It is great for use in WB, IHC, ICC.



SKU: 2025-THRAB

Volume: 100 µL
1-2 business days
Price:
Sale price$445.00

Product Details

Tyrosine Hydroxylase
Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine and norepinephrine. TH antibodies can therefore be used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999). TH antibodies can also be used to explore basic mechanisms of dopamine and norepinephrine signaling (Witkovsky et al., 2000; Salvatore et al., 2001; Dunkley et al., 2004).
Antigen Affinity Purified from Pooled Serum
Polyclonal
IgG
ICC, IHC, WB
Rabbit
TH
60 kDa
SDS-denatured, native rat tyrosine hydroxylase purified from pheochromocytoma.
Human, Mouse, Rat
Chicken
AB_2492276
Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Liquid
Prepared from pooled rabbit serum by affinity purification using a column to which the fusion protein immunogen was coupled.
10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
WB: 1:1000
WB Brain: 1:1000
IHC: 1:1000
ICC: 1:500-1:1000
Unconjugated
Specific for endogenous levels of the ~60 kDa tyrosine hydroxylase protein.
Western blots performed on each lot.
For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
After date of receipt, stable for at least 1 year at -20°C.
Blue Ice
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25085

Product Specific References for Applications and Species

Immunocytochemistry: Human
PMID Dilution Publication
375157631:1000Sheta, R, et al. 2023. Optimized protocol for the generation of functional human induced-pluripotent-stem-cell-derived dopaminergic neurons. STAR protocols, 102486.
Immunocytochemistry: Rat
PMID Dilution Publication
3354843 1:5000 Jaumotte, J.D., et al. 2021. Protection of dopamine neurons by CDNF and neurturin variant N4 against MPP+ in dissociated cultures from rat mesencephalon. Plos One, 16(2), p.e0245663.
25952507 not listed Cooper, R., et al. 2015. Silver nanoparticles at sublethal concentrations disrupt cytoskeleton and neurite dynamics in cultured adult neural stem cells. Neurotoxicology, 48, 231-238.
Immunohistochemistry: Human
PMID Dilution Publication
33113371 1:200 Ye, Y., et al. 2020. . Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass. Cell Reports, 33(4), p.108270.
Immunohistochemistry: Mouse
PMID Dilution Publication
33113371 1:400 Ye, Y., et al. 2020. . Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass. Cell Reports, 33(4), p.108270.
26526844 not listed Ka, M., et al. 2016. Microtubule-Actin Crosslinking Factor 1 Is Required for Dendritic Arborization and Axon Outgrowth in the Developing Brain. Molecular neurobiology, November, 1-15.
Immunohistochemistry: Non-Human Primate
PMID Dilution Publication
33113371 1:400 Ye, Y., et al. 2020. . Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass. Cell Reports, 33(4), p.108270.
Western Blotting: Human
PMID Dilution Publication
33113371 1:2000 Ye, Y., et al. 2020. . Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass. Cell Reports, 33(4), p.108270.
Western Blotting: Mouse
PMID Dilution Publication
34264434 1:2000 Chu, Y., et al. 2021. Gastric Bypass Sensitizes Sympathetic and Thermogenic Activity of Brown Adipose Tissue to Cold Exposure. Obesity Surgery, 31(10), pp.4653-4656.
33113371 1:2000 Ye, Y., et al. 2020. Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass. Cell Reports, 33(4), p.108270.
26526844 1:8000 Ghersa, F., et al. 2019. Reduced inflammatory state promotes reinnervation of endometriotic-like lesions in TNFRp55 deficient mice. Molecular human reproduction. 2019 May 9. pii: gaz026.
Western Blotting: Non-Human Primate
PMID Dilution Publication
33113371 1:2000 Ye, Y., et al. 2020. . Endocannabinoid Receptor-1 and Sympathetic Nervous System Mediate the Beneficial Metabolic Effects of Gastric Bypass. Cell Reports, 33(4), p.108270.

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