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Neurons express distinct proteins at different levels, regions and stages in their development and can be classified by the type of neurotransmitter they produce. Antibodies against various neuronal proteins are useful in distinguishing neurons from other neural cell types, determining the function of neurons (i.e. inhibitory or excitatory) and discovering synaptic partners.
See below for a full list of our neuron marker antibodies, available in several species for ease in multiplexing applications!
Activated Neurons
Neuronal immediate early genes (IEGs) such as c-FOS are rapidly induced by neuronal activity and thus serve as excellent markers of activated neurons.
Immature Neurons
Proteins that are highly expressed in early stages of neuronal development such as beta III tubulin, doublecortin, and GAP43 can be useful in identifying migrating, immature neurons.
| Target | SKU | Species | Applications |
| beta III Tubulin | Chicken Polyclonal Mouse Monoclonal Mouse Monoclonal Rabbit Polyclonal Rabbit Polyclonal Rabbit Polyclonal Rabbit Polyclonal | ICC, IHC, WB IHC, WB ICC, WB ICC, IHC, WB ICC, WB ICC, WB WB | |
| Doublecortin | Chicken Polyclonal Mouse Monoclonal | ICC, IHC ICC, IHC, WB | |
| GAP43 | Chicken Polyclonal | ICC, IHC, WB |
Mature Neurons
Proteins such as MAP2, NeuN, Neurofilaments, Synaptophysin, and NSE that show increased expression in later stages of neuronal development can be used to identify mature, differentiated neurons that are no longer capable of cell division.
| Target | SKU | Species | Applications |
| MAP2 | Chicken Polyclonal Goat Polyclonal Mouse Monoclonal | ICC, IHC, WB ICC, IHC, WB ICC, IHC, WB | |
| NeuN (FOX3) | Mouse Monoclonal | ICC, IHC, WB | |
| Neurofilament Heavy | Chicken Polyclonal Mouse Monoclonal | ICC, IHC, WB ICC, IHC, WB | |
| Neurofilament Medium | Chicken Polyclonal Mouse Monoclonal | ICC, IHC, WB ICC, IHC, WB | |
| Neurofilament Light | Chicken Polyclonal Mouse Monoclonal | ICC, IHC, WB ICC, IHC, WB | |
| Synaptophysin | Rabbit Polyclonal | ICC, WB | |
| NSE | Chicken Polyclonal Mouse Monoclonal Rabbit Polyclonal | ICC, IHC, WB ICC, IHC, WB WB |
Proliferating Neurons
Ki-67 is a nuclear protein that is considered to be essential for cellular proliferation since it is expressed only in active phases of the cell cycle (G1, S, G2 and mitosis) but not in resting phase G0. Ki-67 antibodies have therefore been widely used as markers of cell growth.
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