Our Anti-Ankyrin-B mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N105/13. It detects human, mouse, and rat Ankyrin-B, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.
Ankyrin-2 or -Ankyrin-B is encoded by the gene ANK2. Ankyrin B is a scaffold protein that functions to link proteins that mediate the attachment of integral membrane proteins to the spectrin-actin based membrane cytoskeleton. In this manner, ankyrin family proteins play key roles in various processes including cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Ankyrin B is expressed in brain and muscle. Mutations in this gene cause long QT syndrome 4 and cardiac arrhythmia syndrome.
Purified by Protein A chromatography
1 mg/mL
Monoclonal
N105/13
IgG1
ICC, IHC, IP, WB
Mouse
ANK2 ANKB
>200 kDa
Fusion protein amino acids 203-496 of human Ankyrin-B (accession number Q01484) produced recombinantly in E. Coli
Bovine, Guinea Pig, Human, Mouse, Rat
AB_10673094
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.70
WB: 1:500
IHC: 1:500
ICC: 1:500
IP: 3 ug
Unconjugated
No cross-reactivity reported
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
Patzke, C., et al. 2016. Conditional deletion of L1CAM in human neurons impairs both axonal and dendritic arborization and action potential generation.. Journal of Experimental Medicine, 499-515.
Yoon, S., et al. 2023. Early Developmental Deletion of Forebrain Ank2 Causes Seizure-related Phenotypes by Reshaping the Synaptic Proteome. Cell reports, 112784.
Patzke, C., et al. 2016. Conditional deletion of L1CAM in human neurons impairs both axonal and dendritic arborization and action potential generation.. Journal of Experimental Medicine, 499-515.
Trinh-Trang-Tan, M.M., et al. 2014. AlphaII-spectrin participates in the surface expression of cell adhesion molecule L1 and neurite outgrowth.. Exp Cell Research, 365-380.
Carney, K.E., et al. 2014. Proteomic analysis of gliosomes from mouse brain: identification and investigation of glial membrane proteins.. Journal of Proteome Research, 5918-5927.
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