Anti-Alpha-2C Adrenergic Receptor Antibody FL490 Conjugate (N330A/80)

Name: Anti-Alpha-2C Adrenergic Receptor Antibody FL490 Conjugate
Brand: NeuroMab
SKU: 75-302-FL490
Price: 460.0 USD
Availability: InStock

Our Anti-Alpha-2C adrenergic receptor mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N330A/80. It is KO validated, detects human and mouse Alpha-2C adrenergic receptor, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Species Reactivity

Human, Mouse

Applications

ICC, IHC

Host Species

Mouse

Available Conjugates

Unconjugated

550

594

650

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Data Sheet

KO Validated

SKU: 75-302-FL490

Volume: 200 µL

Variant

Price:

$460.00

Quantity:

Product Details

Target

Alpha-2C adrenergic receptor

Target Description

α-2C adrenergic receptor or α-2 Adrenergic Receptor Subtype C4 is encoded by the gene ADRA2C. It belongs to the Adrenergic receptor subfamily of G-protein coupled receptors. α-2C adrenergic receptors mediate catecholamine-induced inhibition of adenylate cyclase by the action of G proteins. α-2C adrenergic is involved in the regulation of neurotransmitter release from sympathetic nerves and adrenergic neurons. α-2C adrenergic receptors are expressed in brain, kidney and heart. Diseases associated with ADRA2C include Raynaud Phenomenon.

Format

Purified by Protein A chromatography

Concentration

0.5 mg/mL

Clonality

Monoclonal

Clone

N330A/80

Isotype

IgG1

Applications

ICC, IHC

Host Species

Mouse

Gene Name

ADRA2C ADRA2L2 ADRA2RL2

Molecular Weight

50 kDa and larger (possibly due to dimerization)

Antigen

Synthetic peptide amino acids 442-462 (QDFRRSFKHILFRRRRRGFRQ, cytoplasmic C-terminus) of human Alpha-2C adrenergic receptor (accession number P18825)

Species Reactivity

Human, Mouse

Antibody Registry ID

AB_2940056

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL490 Ex: 491 nm, Em: 515 nm

Specificity

Does not cross-react with other adrenergic receptors (based on KO validation results)

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Alpha-2C adrenergic receptor (Alpha-2 adrenergic receptor subtype C4) (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2CAR)

UniProt Details

UniProt (Human): P18825
UniProt (Immunogen Species): P18825

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Anti-Alpha-2C Adrenergic Receptor Antibody FL490 Conjugate (N330A/80)

SKU: 75-302-FL490

Product Details

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