Anti-Ankyrin-G (Staining) Antibody FL550 Conjugate (N106/36)

Name: Anti-Ankyrin-G (Staining) Antibody FL550 Conjugate
Brand: NeuroMab
SKU: 75-146-FL550
Price: 531.0 USD
Availability: InStock

1 Citation

Our Anti-Ankyrin-G (Staining) mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N106/36. It detects feline, hamster, human, mouse, non-human primate, and rat Ankyrin-G (Staining), and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Species Reactivity

Feline, Hamster, Human, Mouse, Non-Human Primate, Rat

Applications

ICC, IHC

Host Species

Mouse

Available Conjugates

Unconjugated

490

594

650

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Data Sheet

SKU: 75-146-FL550

Volume: 200 µL

Variant

Price:

$531.00

Quantity:

Product Details

Target

Ankyrin-G (Staining)

Target Description

Ankyrin-G (ankyrin 3) is a member of the Ankyrin family which consists of Ankyrin R (1), Ankyrin B (2) and Ankyrin G (3) all of which are expressed in the nervous system. Ankyrins are structural proteins that aid in the attachment of integral membrane proteins with the spectrin-actin cytoskeleton, and thus targets voltage-gated sodium channels, potassium channels, cell adhesion molecules and others at the nodes of Ranvier and axonal initial segments (AIS). Variants in Ankyrin G have been linked to bipolar disorder.

Format

Purified by Protein A chromatography

Concentration

0.5 mg/mL

Clonality

Monoclonal

Clone

N106/36

Isotype

IgG2a

Applications

ICC, IHC

Host Species

Mouse

Gene Name

ANK3

Molecular Weight

<200 kDa

Antigen

Fusion protein ~1000 amino acids of Ankyrin-G (accession number E9PE32) produced recombinantly in E. Coli

Species Reactivity

Feline, Hamster, Human, Mouse, Non-Human Primate, Rat

Antibody Registry ID

AB_2939541

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL550 Ex: 550 nm, Em: 575 nm

Specificity

Does not cross-react with Ankyrin-B

Quality Control

Each new lot of antibody is quality control tested by IHC on either rat or mouse brain and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Ankyrin-3 (ANK-3) (Ankyrin-G)

UniProt Details

UniProt (Human): Q12955
UniProt (Immunogen Species): E9PE32

Product Specific References for Applications and Species

Immunocytochemistry: Mouse

Immunocytochemistry: Mouse
PMID	Dilution	Publication
39613768	1:500	Perdok, A., et al. 2024. Altered expression of Presenilin2 impacts endolysosomal homeostasis and synapse function in Alzheimer's disease-relevant brain circuits. Nature Communications, 10412.

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Anti-Ankyrin-G (Staining) Antibody FL550 Conjugate (N106/36)

SKU: 75-146-FL550

Product Details

Product Specific References for Applications and Species

Bulk Order Anti-Ankyrin-G (Staining) Antibody FL550 Conjugate

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