Anti-Beta4-Spectrin Antibody FL650 Conjugate (N393/76)

Name: Anti-Beta4-Spectrin Antibody FL650 Conjugate
Brand: NeuroMab
SKU: 75-377-FL650
Price: 515.0 USD
Availability: InStock

Our Anti-Beta4-spectrin mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N393/76. It detects human, mouse, and rat Beta4-spectrin, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC

Host Species

Mouse

Available Conjugates

Unconjugated

490

550

594

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Data Sheet

SKU: 75-377-FL650

Volume: 200 µL

Variant

Price:

$515.00

Quantity:

Product Details

Target

Beta4-spectrin

Target Description

Spectrin beta chain, non-erythrocytic 4, or ß4 spectrin, is a member of the spectrin family of cytoskeletal proteins. It is found in the cytoskeleton and cell cortex of cells in the brain and pancreatic islets. It is also expressed in skeletal muscule. ß4 spectrin functions as a scaffold protein that links the actin cytoskeleton to the plasma membrane. It is involved in cell shape and organization. Mutations in the ß4 spectrin gene are associated with congenital myopathy, and neurodevelopmental disorder with hypotonia, neuropathy and deafness (NEDHND).

Format

Purified by Protein A chromatography

Concentration

0.5 mg/mL

Clonality

Monoclonal

Clone

N393/76

Isotype

IgG2b

Applications

ICC, IHC

Host Species

Mouse

Gene Name

SPTBN4 KIAA1642 SPTBN3

Molecular Weight

>200 kDa

Antigen

Fusion protein amino acids 1621-1832 (C-terminal repeats 14 to 15) of human Beta4-spectrin (accession number Q9H254) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2940259

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL650 Ex: 655 nm, Em: 676 nm

Specificity

Does not cross-react with other Beta-spectrins

Quality Control

Each new lot of antibody is quality control tested by IHC on either rat or mouse brain and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Spectrin beta chain, non-erythrocytic 4 (Beta-IV spectrin) (Spectrin, non-erythroid beta chain 3)

UniProt Details

UniProt (Human): Q9H254
UniProt (Immunogen Species): Q9H254

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Anti-Beta4-Spectrin Antibody FL650 Conjugate (N393/76)

SKU: 75-377-FL650

Product Details

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