Anti-CDK5 Antibody (1H3)

Name: Anti-CDK5 Antibody
Brand: PhosphoSolutions
SKU: 308-CDK5
Price: 430.0 USD
Availability: InStock

4 Citations

Our Anti-CDK5 primary antibody from PhosphoSolutions is mouse monoclonal. It detects human, mouse, and rat CDK5 and is Protein G purified. It is great for use in WB, IHC.

Western blot of rat striatal lysate showing specific immunolabeling of the ~28 kDa Cdk5 protein.

Species Reactivity

Human, Mouse, Rat

Applications

IHC, WB

Host Species

Mouse

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Data Sheet

Trial Size

SKU: 308-CDK5

Volume: 100 µL

Variant

Price:

$430.00

Quantity:

Product Details

Target

CDK5

Target Description

The neuronal protein kinase, Cdk5 has been implicated in a vast array of normal neuronal functions including regulation of neurotransmitter synthesis (Kansy J et al., 2004), the presynaptic vesicle cycle (Nguyen, C. & Bibb, JA 2003), neurotransmitter receptor trafficking and dopamine neurotransmission (Bibb, JA et al. 1999). At the same time Cdk5 has been implicated in a plethora of neurological and neuropsychiatric disorders including Alzheimer’s, Parkinson’s, Huntington’s, epilepsy, schizophrenia, and drug addiction. Detection of Cdk5 in normal samples as well as tissue undergoing neurodegeneration may advance studies in these areas. Moreover, this antibody may allow more accurate postmortem evaluations of Cdk5 protein expression, and thus serve as a valuable new reagent for neuropathology.

Format

Protein G Purified

Clonality

Monoclonal

Clone

1H3

Isotype

IgG1

Applications

IHC, WB

Host Species

Mouse

Gene Name

CDK5

Molecular Weight

28 kDa

Antigen

Purified rat Cdk5.

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2492053

Storage

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Physical State

Liquid

Production Notes

Protein G purified culture supernatant.

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Dilution Ranges

WB: 1:1000
WB Brain: 1:1000
IHC: 1:50-1:1000

Conjugate

Unconjugated

Specificity

Specific for endogenous levels of the ~28 kDa Cdk5 protein. Shows no cross reactivity with the Cdk5 cofactor p35 or its degradation product p25.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Shipping

Blue Ice

Synonyms

Cdk 5 antibody, Cdk5 antibody, CDK5_HUMAN antibody, Cell division protein kinase 5 antibody, Crk6 antibody, Cyclin dependent kinase 5 antibody, Cyclin-dependent kinase 5 antibody, Protein kinase CDK5 splicing antibody, PSSALRE antibody, Serine threonine protein kinase PSSALRE antibody, Serine/threonine-protein kinase PSSALRE antibody, Tau protein kinase II catalytic subunit antibody, TPKII catalytic subunit antibody

UniProt Details

UniProt (Human): Q13319
UniProt (Immunogen Species): Q03114

NCBI Gene ID

140908

Product Specific References for Applications and Species

Immunohistochemistry: Mouse
Western Blot: Human | Mouse

Immunohistochemistry: Mouse
PMID	Dilution	Publication
34679246	1:100	Terse, A., et al. 2021. Protocols for Characterization of Cdk5 Kinase Activity. Current Protocols, 1(10), p.e276.
27443506	1:50	Hernandez, A., et al. 2016. Cdk5 Modulates Long-Term Synaptic Plasticity and Motor Learning in Dorsolateral Striatum. Scientific Reports, 6.
19017796	1:1000	Lagace, D.C., et al. 2008. Cdk5 is essential for adult hippocampal neurogenesis. Proc Natl Acad Sci USA 105, 18567–18571 (2008).

Western Blot: Human
PMID	Dilution	Publication
29352128	not listed	Hall, B.E., et al. 2018. Phosphorylation of the Transient Receptor Potential Ankyrin 1 by Cyclin-dependent Kinase 5 affects Chemo-nociception. Scientific Reports, 8(1), p.1177.

Western Blot: Mouse
PMID	Dilution	Publication
27443506	1:50	Hernandez, A., et al. 2016. Cdk5 Modulates Long-Term Synaptic Plasticity and Motor Learning in Dorsolateral Striatum. Scientific Reports, 6.

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Product Specific Protocols

Western Blot Protocol: Download

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Anti-CDK5 Antibody (1H3)

SKU: 308-CDK5

Product Details

Product Specific References for Applications and Species

Bulk Order Anti-CDK5 Antibody

Product Specific Protocols

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