Our Anti-FOX1 primary antibody from PhosphoSolutions is mouse monoclonal. It detects bovine, human, mouse, and rat FOX1 and is Protein G purified. It is great for use in WB, IHC, ICC.
Western blot of rat cortical lysate showing specific immunolabeling of the ~46/48 kDa FOX1 protein.
FOX1, also known as ataxin-2 binding protein 1 (A2BP1), is a neuron specific RNA-binding protein that has been shown to regulate a wide range of alternative splicing events implicated in neuronal development and maturation including transcription factors and synaptic proteins (Fogel et al., 2012). Defects in FOX1 have also been associated with autism (Martin et al., 2007), attention-deficit hyperactivity disorder (Elia et al., 2010) and schizophrenia (Xu et al., 2008).
Protein G Purified
Monoclonal
1G10
IgG1
ICC, IHC, WB
Mouse
RBFOX1
46/48 kDa
Recombinant protein taken from the N-terminus of human FOX1 expressed in and purified from E. Coli.
Bovine, Human, Mouse, Rat
AB_2492095
Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.
Liquid
Protein G purified culture supernatant.
PBS + 10 mM NaN3.
WB: 1:5000
WB Brain: 1:5000
IHC: 1:500
ICC: 1:500
Unconjugated
Specific for endogenous levels of the ~46/48 kD FOX1 protein doublet.
Western blots performed on each lot.
For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
After date of receipt, stable for at least 1 year at -20°C.
Blue Ice
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Elia, J., Gai, X., Xie, H.M., Perin, J.C., Geiger, E., Glessner, J.T., D'arcy, M., Deberardinis, R., Frackelton, E., Kim, C. and Lantieri, F., 2010. Rare structural variants found in attention-deficit hyperactivity disorder are preferentially associated with neurodevelopmental genes. Molecular Psychiatry, 15(6), p.637-46. PMID: 19546859
Fogel, B.L., Wexler, E., Wahnich, A., Friedrich, T., Vijayendran, C., Gao, F., Parikshak, N., Konopka, G. and Geschwind, D.H., 2012. RBFOX1 regulates both splicing and transcriptional networks in human neuronal development. Human Molecular Genetics, 21(19), pp.4171-4186. PMID: 22730494
Martin, C.L., Duvall, J.A., Ilkin, Y., Simon, J.S., Arreaza, M.G., Wilkes, K., Alvarez‐Retuerto, A., Whichello, A., Powell, C.M., Rao, K. and Cook, E., 2007. Cytogenetic and molecular characterization of A2BP1/FOX1 as a candidate gene for autism. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 144(7), pp.869-876. PMID: 17503474
Xu, B., Roos, J.L., Levy, S., Van Rensburg, E.J., Gogos, J.A. and Karayiorgou, M., 2008. Strong association of de novo copy number mutations with sporadic schizophrenia. Nature Genetics, 40(7), p.880-5. PMID: 18511947
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