Our Anti-Gamma-protocadherin-C3 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N174B/27. It detects mouse Gamma-protocadherin-C3, and is purified by Protein A chromatography. It is great for use in ICC, WB.
Transfected cell immunoblot: extracts of COS cells transiently transfected with GFP-tagged Gamma- protocadherin-C3 and –A3 and untagged Kv2.1 plasmids and probed with N174B/27 (left) and N159/5 (right) TC supe.
Protocadherin Gamma Subfamily C, 3 is encoded by the gene PCDHGC3. PCDHGC3 is a member of the protocadherin gamma gene cluster. PCDHGC3 is a neural cadherin-like cell adhesion protein that most likely plays a critical role in the establishment and function of specific cell-cell connections in the brain. PCDHGC3 is expressed in the nervous system, liver, and skin. Diseases associated with PCDHGC3 include Corneal Dystrophy, Endothelial, X-Linked and Brachydactyly, Type A3.
Purified by Protein A chromatography
1 mg/mL
Monoclonal
N174B/27
IgG1
ICC, WB
Mouse
Pcdhgc3
100 kDa
Fusion protein amino acids 720-804 (variable cytoplasmic domain) of mouse Gamma-protocadherin-C3 (accession number Q91XX1) produced recombinantly in E. Coli
Mouse
AB_10672245
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125
Unconjugated
No cross-reactivity against other Gamma-protocadherin-A, -B or -C proteins
Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
Garrett, A.M., et al. 2019. CRISPR/Cas9 interrogation of the mouse Pcdhg gene cluster reveals a crucial isoform-specific role for Pcdhgc4. . PLoS genetics, e1008554.
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