Anti-KChIP1 K+ Channel Antibody (K55/7)

Our Anti-KChIP1 K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K55/7. It detects human, mouse, non-human primate, rat, and tree shrew KChIP1 K+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB.



SKU: 75-003

Volume: 100 µL
Price:
Sale price$385.00
Ships: 1-2 business days

Product Details

KChIP1 K+ channel
Kv channel-interacting protein 1, Potassium Voltage-Gated Channel Interacting Protein 1 or Kchip1 is a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin or neuronal calcium sensor (NCS) family branch of the EF-hand superfamily. Kchip1 associates with Kv4 alpha subunits to form native Kv4 channel complexes. Kchip1 is expressed in the brain and detected in the hippocampus and the dentate gyrus. Diseases associated with KCNIP1 include diastolic hypertension, attention deficit-hyperactivity disorder.
Purified by Protein A chromatography
1 mg/mL
Monoclonal
K55/7
IgG1
ICC, IHC, WB
Mouse
Kcnip1 Kchip1
30 kDa
Fusion protein amino acids 1-216 (full length) of rat KChIP1b (accession number Q8R426) produced recombinantly in E. Coli
Human, Mouse, Non-Human Primate, Rat, Tree Shrew
AB_10673162
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4
WB: 1:1000
IHC: 1:500
ICC: 1:500
Unconjugated
No cross-reactivity against rat KChIPs 2,3
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
United States
24 months from date of receipt
Shipped on ice packs
Kv channel-interacting protein 1 (KChIP1) (A-type potassium channel modulatory protein 1) (Potassium channel-interacting protein 1)

Product Specific References for Applications and Species

Immunocytochemistry: Non-Human Primate
PMID Dilution Publication
19350670not listedMikula, S., et al. 2010. Complete 3D visualization of primate striosomes by KChIP1 immunostaining.. Journal of Comparative Neurology, 507-17.
Immunocytochemistry: Rat
PMID Dilution Publication
262392001:300-1:1500Cheng, C.F., et al. 2016. Coexpression of auxiliary subunits KChIP and DPPL in potassium channel Kv4-positive nociceptors and pain-modulating spinal interneurons.. Journal of Comparative Neurology, 846-73.
226123221:500Pruunsild, P. , et al. 2012. Subcellular localization and transcription regulatory potency of KCNIP/Calsenilin/DREAM/KChIP proteins in cultured primary cortical neurons do not provide support for their role in CRE-dependent gene expression.. Journal of Neurochemistry, 29-43.
201546821:250Anderson, D., et al. 2010. Regulation of neuronal activity by Cav3-Kv4 channel signaling complexes.. Nature Neuroscience, 333-7.
Immunohistochemistry: Mouse
PMID Dilution Publication
255454611:500Puighermanal, E., et al. 2015. drd2-cre:ribotag mouse line unravels the possible diversity of dopamine d2 receptor-expressing cells of the dorsal mouse hippocampus.. Hippocampus, 858-75.
22675541not listedManning, C.F., et al. 2012. Benefits and pitfalls of secondary antibodies: why choosing the right secondary is of primary importance.. PLoS One, e38313.
17122038not listedMenegola, M. , et al. 2006. Unanticipated region- and cell-specific downregulation of individual KChIP auxiliary subunit isotypes in Kv4.2 knock-out mouse brain.. Journal of Neuroscience, 2137-42.
Immunohistochemistry: Non-Human Primate
PMID Dilution Publication
347275231:200He, J., et al. 2021. Transcriptional and anatomical diversity of medium spiny neurons in the primate striatum.. Current biology , 5473-5486.e6.
31429499not listedAmemori, S., et al. 2020. Microstimulation of primate neocortex targeting striosomes induces negative decision‐making. . European Journal of Neuroscience, 731-741.
305549031:200Hong, S., et al. 2019. Predominant striatal input to the lateral habenula in macaques comes from striosomes. . Current Biology, 51-61.
297375781:400Amita, H., et al. 2019. Neuronal connections of direct and indirect pathways for stable value memory in caudal basal ganglia.. European Journal of Neuroscience, 712-725.
Immunohistochemistry: Rat
PMID Dilution Publication
324908111:500Oláh, V.J., et al. 2020. Functional specification of CCK+ interneurons by alternative isoforms of Kv4. 3 auxiliary subunits. . Elife, e58515.
283308771:100Kuo, Y.L., et al. 2017. K + Channel Modulatory Subunits KChIP and DPP Participate in Kv4-Mediated Mechanical Pain Control.. Journal of Neuroscience, 4391-4404.
262392001:150-1:300Cheng, C.F., et al. 2016. Coexpression of auxiliary subunits KChIP and DPPL in potassium channel Kv4-positive nociceptors and pain-modulating spinal interneurons.. Journal of Comparative Neurology, 846-73.
253556921:50 (supe)Wang, W.C., et al. 2015. Immunohistochemical localization of DPP10 in rat brain supports the existence of a Kv4/KChIP/DPPL ternary complex in neurons.. Journal of Comparative Neurology, 608-628.
24037673not listedRainnie, D.G., et al. 2014. Distribution and functional expression of Kv4 family α subunits and associated KChIP β subunits in the bed nucleus of the stria terminalis.. Journal of Comparative Neurology, 609-25.
23169482not listedWhite, N.S., et al. 2013. Probing tissue microstructure with restriction spectrum imaging: Histological and theoretical validation.. Human Brain Mapping, 327-46.
211294481:100Bourdeau, M.L., et al. 2011. KChIP1 modulation of Kv4.3-mediated A-type K(+) currents and repetitive firing in hippocampal interneurons.. Neuroscience, 173-87.
208499291:1000Day-Brown, J.D., et al. 2010. Expression and distribution of Kv4 potassium channel subunits and potassium channel interacting proteins in subpopulations of interneurons in the basolateral amygdala.. Neuroscience, 721-33.
18727953not listedMonaghan, M.M., et al. 2008. Altered expression and localization of hippocampal A-type potassium channel subunits in the pilocarpine-induced model of temporal lobe epilepsy.. Neuroscience, 550-62.
18495361not listedMenegola, M., et al. 2008. Dendritic A-type potassium channel subunit expression in CA1 hippocampal interneurons.. Neuroscience, 953-64.
165250471:100Kollo, M., et al. 2006. Novel subcellular distribution pattern of A-type K+ channels on neuronal surface.. Journal of Neuroscience, 2684-91.
Immunohistochemistry: Tree Shrew
PMID Dilution Publication
211201391:5 (supe)Day-Brown, J.D., et al. 2010. Pulvinar projections to the striatum and amygdala in the tree shrew.. Frontiers in Neuroanatomy, 143.
Western Blot: Mouse
PMID Dilution Publication
32562430not listedLee, S.H., et al. 2020. Haploinsufficiency of Cyfip2 Causes Lithium-Responsive Prefrontal Dysfunction.. Annals of Neurology, 526-543.
219436061:1000Sun, W., et al. 2011. DPP6 establishes the A-type K(+) current gradient critical for the regulation of dendritic excitability in CA1 hippocampal neurons.. Neuron, 1102-15.
200454631:1000Lin, L., et al. 2010. KChIP4a regulates Kv4.2 channel trafficking through PKA phosphorylation.. Molecular and Cellular Neuroscience, 315-25.
192236001:1000Alexander, J.C., et al. 2009. The role of calsenilin/DREAM/KChIP3 in contextual fear conditioning.. Learning & Memory, 167-77.
Western Blot: Rat
PMID Dilution Publication
211294481:10Bourdeau, M.L., et al. 2011. KChIP1 modulation of Kv4.3-mediated A-type K(+) currents and repetitive firing in hippocampal interneurons.. Neuroscience, 173-87.
208499291:1000Day-Brown, J.D., et al. 2010. Expression and distribution of Kv4 potassium channel subunits and potassium channel interacting proteins in subpopulations of interneurons in the basolateral amygdala.. Neuroscience, 721-33.
Additional Publications: Unspecified
PMID Publication
23637173Anderson, D., et al. 2013. The Cav3-Kv4 complex acts as a calcium sensor to maintain inhibitory charge transfer during extracellular calcium fluctuations.. Journal of Neuroscience, 7811-24.

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