Anti-Kirrel3 Short And Long Antibody (N321C/49)

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Our Anti-Kirrel3 short and long mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N321C/49. It detects mouse and rat Kirrel3 short and long, and is purified by Protein A chromatography. It is great for use in ICC, WB.

Tissue and transfected cell immunoblot: extracts of rat brain membrane (RBM) and COS cells transiently transfected with Flag-tagged Kirrel3-short, Kirrel3-long, untagged Kirrel2, Kirrel1 or Kv2.1 plasmid and probed with N321C/49 (left) and N52A/42 (right) TC supe.
Tissue and transfected cell immunoblot: extracts of rat brain membrane (RBM) and COS cells transiently transfected with Flag-tagged Kirrel3-short, Kirrel3-long, untagged Kirrel2, Kirrel1 or Kv2.1 plasmid and probed with N321C/49 (left) and N52A/42 (right) TC supe.
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Tissue and transfected cell immunoblot: extracts of rat brain membrane (RBM) and COS cells transiently transfected with Flag-tagged Kirrel3-short, Kirrel3-long, untagged Kirrel2, Kirrel1 or Kv2.1 plasmid and probed with N321C/49 (left) and N52A/42 (right) TC supe.

Mouse, Rat
ICC, WB
Mouse
490
550
594
650
Carrier-Free

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Data Sheet

SKU: 75-333

Volume: 100 µL
1-2 business days
Price:
$329.00

Product Details

Kirrel3 short and long
Kirre Like Nephrin Family Adhesion Molecule 3 is encoded by the gene KIRREL3. KIRREL3 is a member of the immunoglobulin superfamily, nephrin-like protein family. KIRREL3 is a synaptic cell adhesion molecule with multiple extracellular immunoglobulin-like domains and a cytoplasmic PDZ domain-binding motif. KIRREL3 is expressed in brain, bone marrow, and stromal cells. Diseases associated with KIRREL3 include Autosomal Dominant Non-Syndromic Intellectual Disability and Autosomal Dominant Non-Syndromic Intellectual Disability 4.
Purified by Protein A chromatography
1 mg/mL
Monoclonal
N321C/49
IgG2b
ICC, WB
Mouse
Kirrel3 Kirrel3_predicted
85-105 kDa (multiple isoforms)
Fusion protein amino acids 46-524 (extracellular N-terminus) of rat Kirrel3 (accession number Q09GS6) produced recombinantly in E. Coli
Mouse, Rat
AB_2315857
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125
Unconjugated
Reacts with Kirrel3 short and long isoformsDoes not cross-react with Kirrel1 and Kirrel2
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
United States
24 months from date of receipt
Shipped on ice packs
Membrane protein KIRRE
Q09GS6

Product Specific References for Applications and Species

Immunohistochemistry: Mouse
PMID Dilution Publication
36111787not listedLin, J.M., et al. 2022. Sociosexual behavior requires both activating and repressive roles of Tfap2e/ AP-2ε in vomeronasal sensory neurons. Elife, e77259.
347316361:100Wang, J., et al. 2021. Molecular and structural basis of olfactory sensory neuron axon coalescence by Kirrel receptors. Cell reports, 109940.
323410261:100Naik, A.S., et al. 2020. Smad4-dependent morphogenic signals control the maturation and axonal targeting of basal vomeronasal sensory neurons to the accessory olfactory bulb. Development, dev184036.
311425431:100Vaddadi, N., et al. 2019. Kirrel2 is differentially required in populations of olfactory sensory neurons for the targeting of axons in the olfactory bulb. Development, dev173310.
Western Blot: Mouse
PMID Dilution Publication
347316361:100Wang, J., et al. 2021. Molecular and structural basis of olfactory sensory neuron axon coalescence by Kirrel receptors. Cell reports, 109940.
32503885not listedTaylor, M.R., et al. 2020. Kirrel3-Mediated Synapse Formation Is Attenuated by Disease-Associated Missense Variants. Journal of Neuroscience, 5376-5388.

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