Anti-Kv1.3 K+ Channel Antibody (L23/27)
Our Anti-Kv1.3 K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone L23/27. It is KO validated, detects human, mouse, and rat Kv1.3 K+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB.
Adult rat dentate gyrus immunohistochemistry.
Product Specific References for Applications and Species
- Immunocytochemistry: Human | Mouse | Rat
- Immunohistochemistry: Human | Mouse| Rat
- Immunoprecipitation: Mouse | Rat
- TEM: Rat
- Western Blot: Human | Mouse | Rat
- Additional Publications: Unspecified
| Immunocytochemistry: Human | ||
| PMID | Dilution | Publication |
| 30969795 | 1:50 | Solé, L., et al. 2019. The calmodulin‐binding tetraleucine motif of KCNE4 is responsible for association with Kv1. 3. . The FASEB Journal, 8263-8279. |
| 27872049 | 1:200 | Nishijima, Y., et al. 2017. Contribution of Kv1. 5 channel to hydrogen peroxide–induced human arteriolar dilation and its modulation by coronary artery disease. . Circulation research, 658-669. |
| 26655221 | 1:50 | Jiménez-Pérez, L., et al. 2016. Molecular Determinants of Kv1.3 Potassium Channels-induced Proliferation.. The Journal of Biological Chemistry, 3569-3580. |
| Immunocytochemistry: Mouse | ||
| PMID | Dilution | Publication |
| 29947924 | 1:20 (supe) | Pérez-Verdaguer, M., et al. 2018. Caveolar targeting links Kv1. 3 with the insulin-dependent adipocyte physiology. . Cellular and Molecular Life Sciences, 4059-4075. |
| 29272333 | 1:200 | Maezawa, I., et al. 2018. Kv1. 3 inhibition as a potential microglia-targeted therapy for Alzheimer’s disease: preclinical proof of concept. . Brain, 596-612. |
| 27802162 | 1:50 | Solé, L., et al. 2016. The C-terminal domain of Kv1. 3 regulates functional interactions with the KCNE4 subunit. . Journal of Cell Science, 4265-4277. |
| 27302680 | 1:50 | Reeves, T.M., et al. 2016. Targeting Kv1. 3 channels to reduce white matter pathology after traumatic brain injury. . Experimental neurology, 188-203. |
| 26542799 | 1:250 | Martínez-Mármol, R., et al. 2016. Unconventional EGF-induced ERK1/2-mediated Kv1.3 endocytosis.. Cell Mol Life Sciences, 1515-1528. |
| 21233214 | 1:1000 | Fulton, S., et al. 2011. Contribution of Kv1.2 voltage-gated potassium channel to D2 autoreceptor regulation of axonal dopamine overflow.. The Journal of Biological Chemistry, 9360-9372. |
| 20299686 | 1:33 | Cidad, P., et al. 2010. Characterization of ion channels involved in the proliferative response of femoral artery smooth muscle cells.. Arterioscler Thromb Vasc Biol., 1203-1211. |
| Immunocytochemistry: Rat | ||
| PMID | Dilution | Publication |
| 26931497 | 1:20 | Pérez-Verdaguer, M., et al. 2016. Caveolin interaction governs Kv1. 3 lipid raft targeting. . Scientific reports, 1-12. |
| 20810612 | not listed | Hyodo, T., et al. 2010. Voltage-gated potassium channel Kv1.3 blocker as a potential treatment for rat anti-glomerular basement membrane glomerulonephritis.. Am The Journal of Physiology Renal Physiol., F1258-F1269. |
| 18614767 | 1:1190 | Doczi, M.A., et al. 2008. Kv1.3 channels in postganglionic sympathetic neurons: expression, function, and modulation.. Am The Journal of Physiology Regul Integr Comp Physiol., R733-R740. |
| Immunohistochemistry: Human | ||
| PMID | Dilution | Publication |
| 29272333 | 1:150 | Maezawa, I., et al. 2018. Kv1. 3 inhibition as a potential microglia-targeted therapy for Alzheimer’s disease: preclinical proof of concept. . Brain, 596-612. |
| 25175978 | 1:50 or 1:100 | Kundu-Raychaudhuri, S., et al. 2014. Kv1.3 in psoriatic disease: PAP-1, a small molecule inhibitor of Kv1.3 is effective in the SCID mouse psoriasis--xenograft model.. Journal of Autoimmunity, 63-72. |
| Immunohistochemistry: Mouse | ||
| PMID | Dilution | Publication |
| 36640913 | 1:500 | Otuyemi, B., et al. 2023. Domain and Cell Type-specific Immunolocalisation of Voltage-gated Potassium Channels in the Mouse Striatum. Journal of Chemical Neuroanatomy, 102233. |
| 33739978 | not listed | Yi, M.H., et al. 2021. Optogenetic activation of spinal microglia triggers chronic pain in mice. . PLoS biology, e3001154. |
| 31153377 | 1:100 | Gao, T., et al. 2019. Temporal profiling of Kv1. 3 channel expression in brain mononuclear phagocytes following ischemic stroke. . Journal of neuroinflammation, 1-11. |
| 28715117 | 1:5000 | Ohgomori, T., et al. 2017. Differential activation of neuronal and glial STAT 3 in the spinal cord of the SOD 1G93A mouse model of amyotrophic lateral sclerosis.. European Journal of Neuroscience, 2001-2014. |
| 28287632 | not listed | Ramachandran, K.V., et al. 2017. A mammalian nervous-system-specific plasma membrane proteasome complex that modulates neuronal function.. Nature structural & molecular biology, 419-430. |
| 26784004 | 1:1000 | Xu, L., et al. 2016. Neuroinflammation in primary blast neurotrauma: Time course and prevention by torso shielding.. Experimental Neurology, 268-274. |
| 25348824 | not listed | Cidad, P., et al. 2014. K+ channels expression in hypertension after arterial injury, and effect of selective Kv1.3 blockade with PAP-1 on intimal hyperplasia formation.. Cardiovascular Drugs and Therapy, 501-511. |
| 24305723 | 1:50 | Peng, Y., et al. 2014. Blockade of Kv1.3 channels ameliorates radiation-induced brain injury.. Neuro-Oncology, 528-539. |
| 23821603 | not listed | Duque, A., et al. 2014. Expression of Kv1.3 potassium channels regulates density of cortical interneurons.. Developmental Neurobiology, 841-855. |
| 23090990 | 1:100 | Nguyen, H.M., et al. 2012. Modulation of voltage-gated K+ channels by the sodium channel β1 subunit.. Proceedings of the National Academy of Science of the United States of America, 18577-18582. |
| 21859894 | 1:500 | Roepke, T.K., et al. 2011. KCNE2 forms potassium channels with KCNA3 and KCNQ1 in the choroid plexus epithelium.. The FASEB Journal, 4264-4273. |
| 21233214 | 1:1000 | Fulton, S., et al. 2011. Contribution of Kv1.2 voltage-gated potassium channel to D2 autoreceptor regulation of axonal dopamine overflow.. The Journal of Biological Chemistry, 9360-9372. |
| 20575068 | 1:100 | Gazula, V.R., et al. 2010. Localization of Kv1.3 channels in presynaptic terminals of brainstem auditory neurons.. Journal of Comparative Neurology, 3205-20. |
| 20299686 | not listed | Cidad, P., et al. 2010. Characterization of ion channels involved in the proliferative response of femoral artery smooth muscle cells.. Arterioscler Thromb Vasc Biol., 1203-1211. |
| Immunohistochemistry: Rat | ||
| PMID | Dilution | Publication |
| 27302680 | 1:50 | Reeves, T.M., et al. 2016. Targeting Kv1. 3 channels to reduce white matter pathology after traumatic brain injury. . Experimental neurology, 188-203. |
| 24723263 | 1:100 | Dufour, M.A., et al. 2014. Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development.. Journal of Neuroscience Research, 981-99. |
| 23318870 | not listed | Ovsepian, S.V., et al. 2013. A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets.. The Journal of Physiology, 1771-91. |
| 22218089 | 1:1000 | He, S., et al. 2012. Increased Kv1 channel expression may contribute to decreased sIPSC frequency following chronic inhibition of NR2B-containing NMDAR.. Neuropsychopharmacology, 1338-1356. |
| 21430270 | not listed | Ramirez-Navarro, A., et al. 2011. Kv1.3 channels regulate synaptic transmission in the nucleus of solitary tract.. Journal of Neurophysiology, 2772-2780. |
| 20371822 | 1:100 | Wang, T., et al. 2010. Activated T-cells inhibit neurogenesis by releasing granzyme B: rescue by Kv1.3 blockers.. Journal of Neuroscience, 5020-5027. |
| Immunoprecipitation: Mouse | ||
| PMID | Dilution | Publication |
| 29947924 | not listed | Pérez-Verdaguer, M., et al. 2018. Caveolar targeting links Kv1. 3 with the insulin-dependent adipocyte physiology. . Cellular and Molecular Life Sciences, 4059-4075. |
| 24043354 | not listed | Hamilton, D.L., et al. 2014. Kv1.3 inhibitors have differential effects on glucose uptake and AMPK activity in skeletal muscle cell lines and mouse ex vivo skeletal muscle.. The Journal of Physiology Sci., 13-20. |
| Immunoprecipitation: Rat | ||
| PMID | Dilution | Publication |
| 24043354 | not listed | Hamilton, D.L., et al. 2014. Kv1.3 inhibitors have differential effects on glucose uptake and AMPK activity in skeletal muscle cell lines and mouse ex vivo skeletal muscle.. The Journal of Physiology Sci., 13-20. |
| Transmission Electron Microscopy: Rat | ||
| PMID | Dilution | Publication |
| 35402277 | 1:50 | Capera, J., et al. 2022. The Mitochondrial Routing of the Kv1. 3 Channel. . Frontiers in Oncology, 865686-865686. |
| Western Blot: Human | ||
| PMID | Dilution | Publication |
| 35396942 | 1:200 | Roig, S.R., et al. 2022. S-acylation-dependent membrane microdomain localization of the regulatory Kvβ2. 1 subunit. . Cellular and Molecular Life Sciences, 230. |
| 27872049 | 1:2000 | Nishijima, Y., et al. 2017. Contribution of Kv1. 5 channel to hydrogen peroxide–induced human arteriolar dilation and its modulation by coronary artery disease. . Circulation research, 658-669. |
| 27802162 | 1:200 | Solé, L., et al. 2016. The C-terminal domain of Kv1. 3 regulates functional interactions with the KCNE4 subunit. . Journal of Cell Science, 4265-4277. |
| 27439875 | not listed | Kang, J.A., et al. 2016. Epigenetic regulation of Kcna3-encoding Kv1.3 potassium channel by cereblon contributes to regulation of CD4+ T-cell activation.. Proceedings of the National Academy of Science of the United States of America, 8771-8776. |
| 21586699 | 1:1000 | Straub, S.V., et al. 2011. Pharmacological inhibition of Kv1.3 fails to modulate insulin sensitivity in diabetic mice or human insulin-sensitive tissues.. Am The Journal of Physiology Endocrinol Metab., E380-E390. |
| Western Blot: Mouse | ||
| PMID | Dilution | Publication |
| 38194969 | not listed | Miyazaki, Y, et al. 2024. Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity. Cell Reports, 113634. |
| 31028120 | not listed | Dong, X., et al. 2019. Dlg1 maintains dendritic cell function by securing voltage-gated K+ channel integrity. . The Journal of Immunology, 3187-3197. |
| 29947924 | 1:200 | Pérez-Verdaguer, M., et al. 2018. Caveolar targeting links Kv1. 3 with the insulin-dependent adipocyte physiology. . Cellular and Molecular Life Sciences, 4059-4075. |
| 29272333 | 1:700 | Maezawa, I., et al. 2018. Kv1. 3 inhibition as a potential microglia-targeted therapy for Alzheimer’s disease: preclinical proof of concept. . Brain, 596-612. |
| 28186199 | 1:200 | Martínez-Mármol, R., et al. 2017. Ubiquitination mediates Kv1. 3 endocytosis as a mechanism for protein kinase C-dependent modulation. . Scientific reports, 1-16. |
| 27802162 | 1:200 | Solé, L., et al. 2016. The C-terminal domain of Kv1. 3 regulates functional interactions with the KCNE4 subunit. . Journal of Cell Science, 4265-4277. |
| 24043354 | 1:1000 | Hamilton, D.L., et al. 2014. Kv1.3 inhibitors have differential effects on glucose uptake and AMPK activity in skeletal muscle cell lines and mouse ex vivo skeletal muscle.. The Journal of Physiology Sci., 13-20. |
| 21859894 | 1:500 | Roepke, T.K., et al. 2011. KCNE2 forms potassium channels with KCNA3 and KCNQ1 in the choroid plexus epithelium.. The FASEB Journal, 4264-4273. |
| 20575068 | not listed | Gazula, V.R., et al. 2010. Localization of Kv1.3 channels in presynaptic terminals of brainstem auditory neurons.. Journal of Comparative Neurology, 3205-20. |
| Western Blot: Rat | ||
| PMID | Dilution | Publication |
| 34234241 | 1:500 | Roig, S.R., et al. 2021. Calmodulin-dependent KCNE4 dimerization controls membrane targeting. Scientific reports, 11(1), pp.1-16.. Scientific reports, 1-16. |
| 27816768 | 1:1000 | Liu, H., et al. 2017. Human immunodeficiency virus protein Tat induces oligodendrocyte injury by enhancing outward K+ current conducted by KV1. 3. . Neurobiology of disease, 1-10. |
| 26931497 | 1:500 | Pérez-Verdaguer, M., et al. 2016. Caveolin interaction governs Kv1. 3 lipid raft targeting. . Scientific reports, 1-12. |
| 24043354 | 1:1000 | Hamilton, D.L., et al. 2014. Kv1.3 inhibitors have differential effects on glucose uptake and AMPK activity in skeletal muscle cell lines and mouse ex vivo skeletal muscle.. The Journal of Physiology Sci., 13-20. |
| 22613618 | not listed | Zhu, J., et al. 2012. N-glycosylation promotes the cell surface expression of Kv1.3 potassium channels.. The FEBS Journal, 2632-2644. |
| 18614767 | 1:5000 | Doczi, M.A., et al. 2008. Kv1.3 channels in postganglionic sympathetic neurons: expression, function, and modulation.. Am The Journal of Physiology Regul Integr Comp Physiol., R733-R740. |
| Additional Publications: Unspecified | ||
| PMID | Publication | |
| 24723263 | Dufour, M.A., et al. 2014. Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development.. Journal of Neuroscience Research, 981-999. | |
| 22987820 | Yamada, J., et al. 2013. Novel objective classification of reactive microglia following hypoglossal axotomy using hierarchical cluster analysis.. Journal of Comparative Neurology, 1184-1201. | |