Our Anti-Kv7.1/KCNQ1 K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N37A/10. It detects hamster, human, mouse, rabbit, rat, and Xenopus Kv7.1/KCNQ1 K+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB.
Transfected cell immunofluorescence: COS-1 cells expressing KCNQ1. Red = N37A/10, Blue = Hoechst nuclear stain.
Potassium voltage-gated channel subfamily Q member 1 is encoded by the gene KCNQ1. KCNQ1 is a member of the potassium channel family, KQT (TC 1.A.1.15) subfamily, Kv7.1/KCNQ1 sub-subfamily. KCNQ1 is a voltage-gated potassium channel that is required for the repolarization phase of the cardiac action potential. KCNQ1 can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3. KCNQ1 is expressed in the heart, pancreas, kidney, prostate, small intestine, and peripheral blood leukocytes. Diseases associated with KCNQ1 include Long QT Syndrome1, Jervell and Lange-Nielsen Syndrome, atrial fibrillation familial 3, short QT syndrome 2, and atrial fibrillation.
Purified by Protein A chromatography
1 mg/mL
Monoclonal
N37A/10
IgG1
ICC, IHC, IP, WB
Mouse
KCNQ1 KCNA8 KCNA9 KVLQT1
75 kDa
Fusion protein amino acids 2-101 of human KCNQ1(accession number P51787) produced recombinantly in E. Coli
Hamster, Human, Mouse, Rabbit, Rat, Xenopus
AB_2131682
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.11
WB: 1:500
IHC: 1:100
ICC: 1:100
Unconjugated
No cross-reactivity reported
Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
Salomonsson, M., et al. 2015. K(V)7.4 channels participate in the control of rodent renal vascular resting tone. Acta physiologica (Oxford, England), 402-414.
Salomonsson, M., et al. 2015. K(V)7.4 channels participate in the control of rodent renal vascular resting tone. Acta physiologica (Oxford, England), 402-414.
Sachse, C., et al. 2013. BACE1 and presenilin/γ-secretase regulate proteolytic processing of KCNE1 and 2, auxiliary subunits of voltage-gated potassium channels. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2458-2467.
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Dressler, F., et al. 2017. Interregional electro-mechanical heterogeneity in the rabbit myocardium. Progress in biophysics and molecular biology, 344-355.
Le Quilliec, E, et al. 2024. Atrial cardiomyocytes contribute to the inflammatory status associated with atrial fibrillation in right heart disease. Europace\, 0.
Testai, L., et al. 2016. Expression and function of Kv7.4 channels in rat cardiac mitochondria: possible targets for cardioprotection. Cardiovascular research, 40-50.
