Anti-Laforin Antibody FL550 Conjugate (N84/37)

Name: Anti-Laforin Antibody FL550 Conjugate
Brand: NeuroMab
SKU: 75-222-FL550
Price: 460.0 USD
Availability: InStock

Our Anti-Laforin mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N84/37. It detects human Laforin, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Species Reactivity

Human

Applications

ICC, IHC

Host Species

Mouse

Available Conjugates

Unconjugated

490

594

650

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Data Sheet

SKU: 75-222-FL550

Volume: 200 µL

Variant

Price:

$460.00

Quantity:

Product Details

Target

Laforin

Target Description

Epilepsy, Progressive Myoclonus Type 2A, Lafora Disease (Laforin) is encoded by the gene EPM2A. EPM2A is a member of the protein-tyrosine phosphatase family. EPM2A is a dual-specificity phosphatase that acts on complex carbohydrates to prevent glycogen hyperphosphorylation and the formation of insoluble aggregates. EPM2A promotes the ubiquitination of proteins involved in glycogen metabolism via its interactions with the E3 ubiquitin ligase NHLRC1/malin. EPM2A is expressed in the heart, skeletal muscle, kidney, pancreas, and the brain. Diseases associated with EPM2A include Myoclonic Epilepsy of Lafora, Myoclonic Epilepsy of Unverricht And Lundborg, and benign epilepsy with centrotemporal spikes.

Format

Purified by Protein A chromatography

Concentration

0.5 mg/mL

Clonality

Monoclonal

Clone

N84/37

Isotype

IgG1

Applications

ICC, IHC

Host Species

Mouse

Gene Name

EPM2A

Molecular Weight

40 kDa

Antigen

Fusion protein amino acids 1-331 (full-length) of human Laforin (accession number O095278) produced recombinantly in E. Coli

Species Reactivity

Human

Antibody Registry ID

AB_2939817

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL550 Ex: 550 nm, Em: 575 nm

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Laforin (EC 3.1.3.-) (EC 3.1.3.16) (EC 3.1.3.48) (Glucan phosphatase) (Glycogen phosphatase) (Lafora PTPase) (LAFPTPase)

UniProt Details

UniProt (Human): O95278
UniProt (Immunogen Species): O95278

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Anti-Laforin Antibody FL550 Conjugate (N84/37)

SKU: 75-222-FL550

Product Details

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