Our Anti-NR2A glutamate receptor mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N327A/38. It detects human, mouse, and rat NR2A glutamate receptor, and is TC supernatant. It is great for use in IHC, ICC, WB.
Transfected cell immunoblot: extracts of COS cells transiently transfected with GFP-tagged NR2A, NR2B or untagged Kv2.1 plasmid and probed with N327A/38 (left) and N86/38 (right) TC supe.
Glutamate receptor NMDA2A or GluN2A/NR2A glutamate receptor is a member of the glutamate-gated ion channel family. NR2A is a subunit of the ligand-gated ion channel with high calcium permeability and voltage-dependent sensitivity to magnesium. NR2A is expressed throughout the brain, including striatum, forbrain, cerebellum (at protein level) brain cortex, piriform cortex, hippocampus, caudate-putamen, dentate gyrus and granule cell layer. It is found at the postsynaptic cell membrane, dendritic spine, synapse, and cytoplasmic vesicle membrane. A variety of neurological diseases, including epilepsy, intellectual disability, autism spectrum disorders, developmental delay, and schizophrenia are associated with mutations in the NR2A gene.
TC Supernatant
Lot dependent
Monoclonal
N327A/38
IgG2b
ICC, IHC, WB
Mouse
Grin2a
170 kDa
Fusion protein amino acids 75-325 (extracellular N-terminus) of rat NR2A (accession number Q00959) produced recombinantly in E. Coli
Human, Mouse, Rat
AB_2315843
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Supernatant is harvested from hybridoma cells grown under standard cell culture conditions
Supernatant is provided in cell culture medium with 0.1% sodium azide as anti-microbial
Unconjugated
Does not cross-react with NR2B
Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
