Our Nurr1 rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human, mouse, and rat Nurr1 and is antigen affinity purified. It is great for use in WB.
Immunohistochemistry of adult rat brain hippocampus showing specific staining of Nurr1. Tissue was fixed in paraformaldehyde and cut into 20 micron sections.
The Nurr1 gene encodes a member of the steroid-thyroid hormone- retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson's. Nurr1 is a stem cell marker and cooperates with PITX3 to promote terminal maturation of murine and human embryonic stem cell cultures to a midbrain dopamine neuron phenotype. In addition, Nurr1 is involved in the regulation of corticotropin-releasing hormone (CRH), which may be linked to and associated with rheumatoid arthritis.
Antigen Affinity Purified
Polyclonal
IgG
WB
Rabbit
NR4A2
Synthetic peptide corresponding to amino acids from an internal sequence of the human Nurr1 protein
Human, Mouse, Rat
Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.
Liquid
PBS + 0.02% NaN3
WB: 1:500-1:1000
WB Brain: 1:500-1:1000
Reacts with an internal sequence of the human Nurr1 protein. Also reacts with rat and mouse Nurr1.
Western blots performed on each lot.
For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
United States
After date of receipt, stable for at least 1 year at -20°C.
Blue Ice
NR4A2, Nuclear receptor subfamily 4 group A member 2, Immediate-early response protein NOT, Orphan nuclear receptor NURR1, Transcriptionally-inducible nuclear receptor, NOT, NURR1, TINUR
