Anti-OCRL/INPP5b Antibody (N166A/26)

5 Citations

Our Anti-OCRL/INPP5b mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N166A/26. It detects human, mouse, and rat OCRL/INPP5b, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.

Transfected cell immunoblot: extracts of COS cells transiently transfected with untagged Kv2.1, GFP-tagged OCRL or RFP-tagged INPP5b plasmids and probed with N166A/26 (left) and another cross-reacting mouse OCRL antibody (right).
Transfected cell immunoblot: extracts of COS cells transiently transfected with untagged Kv2.1, GFP-tagged OCRL or RFP-tagged INPP5b plasmids and probed with N166A/26 (left) and another cross-reacting mouse OCRL antibody (right).
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Transfected cell immunoblot: extracts of COS cells transiently transfected with untagged Kv2.1, GFP-tagged OCRL or RFP-tagged INPP5b plasmids and probed with N166A/26 (left) and another cross-reacting mouse OCRL antibody (right).

Human, Mouse, Rat
ICC, WB
Mouse
490
550
594
650
Carrier-Free

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Data Sheet

SKU: 75-215

Volume: 100 µL
Price:
$329.00
Ships: 1-2 business days

Product Details

OCRL/INPP5b
Inositol polyphosphate 5-phosphatase B is encoded by the gene INPP5B. INPP5B is a member of the inositol 1,4,5-triphosphate 5-phosphatase family. INPP5B functions in the regulation of calcium signaling by inactivating inositol phosphates. INPP5B is expressed highest in the urinary bladder. Diseases associated with INPP5B include dent disease 2, lowe oculocerebrorenal syndrome, charcot-marie-tooth disease type 4j, dent disease 1, and frontotemporal dementia and/or amyotrophic lateral sclerosis 2.
Purified by Protein A chromatography
1 mg/mL
Monoclonal
N166A/26
IgG1
ICC, WB
Mouse
INPP5B OCRL2
100 kDa
Fusion protein amino acids 1-901 (full-length) of human OCRL (accession number Q01968) produced recombinantly in E. Coli
Human, Mouse, Rat
AB_2156491
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125
Unconjugated
Cross-reacts with INPP5b
Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
United States
24 months from date of receipt
Shipped on ice packs
Type II inositol 1,4,5-trisphosphate 5-phosphatase (EC 3.1.3.36) (75 kDa inositol polyphosphate-5-phosphatase) (Phosphoinositide 5-phosphatase) (5PTase)
Q01968

Product Specific References for Applications and Species

Immunocytochemistry: Human
PMID Dilution Publication
22543976not listedLuo, N., et al. 2012. OCRL localizes to the primary cilium: a new role for cilia in Lowe syndrome. Human Molecular Genetics, 3333-3344.
Immunocytochemistry: Mouse
PMID Dilution Publication
33987909not listedWang, B., et al. 2021 . OCRL regulates lysosome positioning and mTORC1 activity through SSX2IP-mediated microtubule anchoring. EMBO Reports, e52173.
Western Blot: Human
PMID Dilution Publication
22543976not listedLuo, N., et al. 2012. OCRL localizes to the primary cilium: a new role for cilia in Lowe syndrome. Human Molecular Genetics, 3333-3344.
Western Blot: Mouse
PMID Dilution Publication
33987909not listedWang, B., et al. 2021 . OCRL regulates lysosome positioning and mTORC1 activity through SSX2IP-mediated microtubule anchoring. EMBO Reports, e52173.
Additional Publications: Unspecified
PMID Publication
27060558Clasadonte, J., et al. 2016. Molecular analysis of acute and chronic reactive astrocytes in the pilocarpine model of temporal lobe epilepsy. Neurobiology of Disease, 315-325.

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