Anti-Pan-Gamma-Protocadherin-A Antibody FL490 Conjugate (N144/32)

Name: Anti-Pan-Gamma-Protocadherin-A Antibody FL490 Conjugate
Brand: NeuroMab
SKU: 75-178-FL490
Price: 460.0 USD
Availability: InStock

Our Anti-Pan-Gamma-protocadherin-A mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N144/32. It is KO validated, detects mouse Pan-Gamma-protocadherin-A, and is purified by Protein A chromatography. It is great for use in ICC.

Species Reactivity

Mouse

Applications

ICC

Host Species

Mouse

Available Conjugates

Unconjugated

550

594

650

Go to Full Product Details

Data Sheet

KO Validated

SKU: 75-178-FL490

Volume: 200 µL

Variant

Price:

$460.00

Quantity:

Product Details

Target

Pan-Gamma-protocadherin-A

Target Description

Cadherins are calcium-dependent cell-cell adhesion molecules, and protocadherins constitute a subfamily of non-classic cadherins. Members of the protocadherin gamma subfamily are encoded by 22 tandemly arranged genes within the PCDHG gene cluster on chromosome 5q31. The 22 PCDHG genes function as 'variable' exons that are individually spliced to a downstream constant region to form distinct PCDHG transcripts. The variable PCDHG exons encode the extracellular and transmembrane domains of the protocadherin protein, and the common region encodes the intracellular domain. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain.

Format

Purified by Protein A chromatography

Concentration

0.5 mg/mL

Clonality

Monoclonal

Clone

N144/32

Isotype

IgG2b

Applications

ICC

Host Species

Mouse

Gene Name

Pcdhga3

Molecular Weight

100 kDa

Antigen

Fusion protein corresponding to amino acids 720-804 (variable cytoplasmic domain) of mouse Gamma-protocadherin-A3 (accession number Q91XY5) produced recombinantly in E. Coli

Species Reactivity

Mouse

Antibody Registry ID

AB_2939656

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL490 Ex: 491 nm, Em: 515 nm

Specificity

Cross-reacts with all Gamma protocadherin-A, -B and -C proteins

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Protocadherin gamma A3 (Protocadherin gamma subfamily A, 3)

UniProt Details

UniProt (Human): N/A
UniProt (Immunogen Species): Q91XY5

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Anti-Pan-Gamma-Protocadherin-A Antibody FL490 Conjugate (N144/32)

SKU: 75-178-FL490

Product Details

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