Anti-Parvalbumin Antibody (L114/3)

8 Citations

Our Anti-Parvalbumin mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone L114/3. It detects mouse and rat Parvalbumin, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.

Adult rat hippocampus immunohistochemistry.
Adult rat hippocampus immunohistochemistry.
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Adult rat hippocampus immunohistochemistry.
Adult rat striatum immunohistochemistry.
Adult rat thalamus immunohistochemistry.
Adult rat brain low-speed pellet immunoblot.

Mouse, Rat
ICC, IHC, WB
Mouse
490
550
594
650
Carrier-Free

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Data Sheet

SKU: 75-455

Volume: 100 µL
Price:
$329.00
Ships: 1-2 business days

Product Details

Parvalbumin
Parvalbumin (PA) is a classical small, mostly cytosolic Ca2+-binding protein of the EF-hand superfamily expressed in vertebrates in a tissue- and cell-specific manner, serving as a magnesium/ calcium buffer (Permyakov EA et al., 2017). Parvalbumin (PV)-expressing interneurons are a class of inhibitory neurons that fire rapid barrages of action potentials, and are accordingly named “fast-spiking” interneurons (Trachtenberg J. 2015).
Purified by Protein A chromatography
1 mg/mL
Monoclonal
L114/3
IgG2a
ICC, IHC, WB
Mouse
Pvalb Pva
20 kDa
Fusion protein amino acids 1-110 (full-length) of rat Parvalbumin (accession number P02625) produced recombinantly in E. Coli
Mouse, Rat
AB_2651167
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125
IHC: 1:500
ICC: 1:1000
Unconjugated
No cross-reactivity reported
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
United States
24 months from date of receipt
Shipped on ice packs
Parvalbumin alpha
P02625

Product Specific References for Applications and Species

  • Immunocytochemistry: Rat
  • Immunohistochemistry: Mouse | Rat
  • Western Blot: Mouse
Immunocytochemistry: Rat
PMID Dilution Publication
325425951:1000Rahman-Enyart, A., et al. 2020. Neuregulins 1,2,and 3 Promote Early Neurite Outgrowth in Erb4-Expressing Cortical GABAergic Interneurons. Molecular Neurobiology, 3568-3588.
Immunohistochemistry: Mouse
PMID Dilution Publication
387497011:20Danis, AB, et al. 2024. Altered Hippocampal Activation in Seizure-Prone CACNA2D2 Knock-out Mice. eNeuro, .
341803931:250Stevens, S.R., et al. 2021. Ankyrin-R regulates fast-spiking interneuron excitability through perineuronal nets and Kv3. 1b K+ channels. . Elife, e66491.
339105991:100Haigh, J.L., et al. 2021. Deletion of a non-canonical regulatory sequence causes loss of Scn1a expression and epileptic phenotypes in mice.. Genome Medicine, 69.
331322031:5 (supe)Hawkins, N.A., et al. 2021. Epilepsy and neurobehavioral abnormalities in mice with a dominant-negative KCNB1 pathogenic variant. Neurobiology Disorders, 105141.
324251571:500Liu, C.H., et al. 2020. β spectrin-dependent and domain specific mechanisms for Na + channel clustering. Elife, e56629.
Immunohistochemistry: Rat
PMID Dilution Publication
37758930not listedMitchell, K.G., et al. 2023. High-volume hybridoma sequencing on the NeuroMabSeq platform enables efficient generation of recombinant monoclonal antibodies and scFvs for neuroscience research. Scientific Reports, 16200.
Western Blot: Mouse
PMID Dilution Publication
331322031:5 (supe)Hawkins, N.A., et al. 2021. Epilepsy and neurobehavioral abnormalities in mice with a dominant-negative KCNB1 pathogenic variant. Neurobiology Disorders, 105141.

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