Anti-Synapsin-3 Antibody (L125/121)

Name: Anti-Synapsin-3 Antibody
Brand: NeuroMab
SKU: 75-494
Price: 319.0 USD
Availability: InStock

Our Anti-Synapsin-3 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone L125/121. It detects human, mouse, and rat Synapsin-3, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.

Immunoblot against extracts of COS cells transiently transfected with Myc-tagged SYN1, SYN3 or untagged Kv2.1 plasmid probed with L125/121 (left) or 9E10 (right) TC supe..

Adult rat hippocampus immunohistochemistry.

Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC, WB

Host Species

Mouse

Available Conjugates

490

550

594

650

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Data Sheet

SKU: 75-494

Product Details

Target

Synapsin-3

Target Description

The synapsin family of proteins are neuron specific phospho-proteins comprised of synapsins I, II and III. Synapsins I and II are abundantly expressed pre-synaptic proteins that play key roles in synaptic plasticity and synaptogenesis (Feng et al., 2002; Nayak et al., 1996). Synapsin III is the most recent member of the synapsin family to be indentified and is primarily expressed in extra-synaptic sites such as cell bodies and growth cones (Ferreira A. et al., 2000). Synapsin III is expressed at much lower levels than synapsin I and II in the adult brain and is therefore thought to be involved in early neural development (Kao HT, et al., 1998).

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

L125/121

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

SYN3

Molecular Weight

60 kDa

Antigen

Fusion protein amino acids 76-417 (actin-binding and synaptic-vesicle binding domains) of human Synapsin-III (accession number O14994) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2725816

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Synapsin-III (Synapsin-3)

UniProt Details

UniProt (Human): O14994
UniProt (Immunogen Species): O14994

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Anti-Synapsin-3 Antibody (L125/121)

SKU: 75-494

Product Details

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