Anti-SynDIG1/Tmem90b Antibody (L42/17)

Name: Anti-SynDIG1/Tmem90b Antibody
Brand: NeuroMab
SKU: 75-251
Price: 319.0 USD
Availability: InStock

6 Citations

Our Anti-SynDIG1/Tmem90b mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone L42/17. It detects human, mouse, and rat SynDIG1/Tmem90b, and is purified by Protein A chromatography. It is great for use in ICC, WB.

Adult rat brain membrane immunoblot.

Species Reactivity

Human, Mouse, Rat

Applications

ICC, WB

Host Species

Mouse

Available Conjugates

490

550

594

650

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Data Sheet

SKU: 75-251

Volume: 100 µL

Variant

Price:

$319.00

Quantity:

Product Details

Target

SynDIG1/Tmem90b

Target Description

Transmembrane Protein 90B or Synapse Differentiation Inducing 1 (SynDIG1/Tmem90b) is encoded by the gene SYNDIG1 and a member of the interferon-induced transmembrane family of proteins. (IFITM). SynDIG1 is thought to regulate AMPA receptors and be involved in postsynaptic development and maturation. SynDIG1 is expressed in the brain at excitatory synapses and postsynaptic cells. Diseases associated with this gene include Episodic Kinesigenic Dyskinesia and Visual Epilepsy.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

L42/17

Isotype

IgG2a

Applications

ICC, WB

Host Species

Mouse

Gene Name

Syndig1 Tmem90b

Molecular Weight

36 kDa

Antigen

Fusion protein amino acids 1-183 (cytoplasmic N-terminus) of mouse SynDIG1 (accession number A2ANU3) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_10999753

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Synapse differentiation-inducing gene protein 1 (SynDIG1) (Dispanin subfamily C member 2) (DSPC2) (Transmembrane protein 90B)

UniProt Details

UniProt (Human): Q9H7V2
UniProt (Immunogen Species): A2ANU3

Product Specific References for Applications and Species

Immunocytochemistry: Rat
Immunoprecipitation: Mouse
Western Blot: Mouse | Rat

Immunocytochemistry: Rat
PMID	Dilution	Publication
35465096	1:200	Plambeck, K.E., et al. 2022. Mutually Dependent Clustering of SynDIG4/PRRT1 and AMPA Receptor Subunits GluA1 and GluA2 in Heterologous Cells and Primary Neurons. Frontiers in Molecular Neuroscience, 788620.
26660156	1:1000	Kirk, L.M., et al. 2016. Distribution of the SynDIG4/proline-rich transmembrane protein 1 in rat brain.. Journal of Comparative Neurology, 2266-2280.
20152115	not listed	Kalashnikova, E., et al. 2010. SynDIG1: an activity-regulated, AMPA- receptor-interacting transmembrane protein that regulates excitatory synapse development.. Neuron, 80-93.

Immunoprecipitation: Mouse
PMID	Dilution	Publication
20152115	not listed	Kalashnikova, E., et al. 2010. SynDIG1: an activity-regulated, AMPA- receptor-interacting transmembrane protein that regulates excitatory synapse development.. Neuron, 80-93.

Western Blot: Mouse
PMID	Dilution	Publication
27800545	not listed	Chenaux, G., et al. 2016. Loss of SynDIG1 Reduces Excitatory Synapse Maturation But Not Formation In Vivo. eNeuro, .
22002768	not listed	Sumioka, A., et al. 2011. PDZ binding of TARPγ-8 controls synaptic transmission but not synaptic plasticity.. Nature Neuroscience, 1410-1412.
20152115	not listed	Kalashnikova, E., et al. 2010. SynDIG1: an activity-regulated, AMPA- receptor-interacting transmembrane protein that regulates excitatory synapse development.. Neuron, 80-93.

Western Blot: Rat
PMID	Dilution	Publication
26660156	1:1000	Kirk, L.M., et al. 2016. Distribution of the SynDIG4/proline-rich transmembrane protein 1 in rat brain.. Journal of Comparative Neurology, 2266-2280.

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Anti-SynDIG1/Tmem90b Antibody (L42/17)

SKU: 75-251

Product Details

Product Specific References for Applications and Species

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