Anti-Testicular Receptor 2 (TR2) Antibody

8 Citations

Our Anti-Testicular Receptor 2 (TR2) primary antibody from PhosphoSolutions is rabbit polyclonal. It detects human, mouse, and rat Testicular Receptor 2 (TR2) and is neat serum. It is great for use in WB.

Western blot of rat testicular lysate showing specific immunolabeling of the ~64 kDa TR2 protein.
Western blot of rat testicular lysate showing specific immunolabeling of the ~64 kDa TR2 protein.
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Western blot of rat testicular lysate showing specific immunolabeling of the ~64 kDa TR2 protein.

Human, Mouse, Rat
WB
Rabbit

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Data Sheet
Trial Size Trial Size

SKU: 2002-TR2

Volume: 100 µL
Price:
$385.00
Ships: 1-2 business days

Product Details

Testicular Receptor 2 (TR2)
Testicular receptor 2 (TR2) is a member of the orphan nuclear receptor family. It is widely expressed at a low level throughout the adult testis. TR2 represses transcription and binds DNA directly interacting with HDAC3 and HDAC4 via DNA-binding domains (Franco et al., 2003). TR2 has also been implicated in regulation of estrogen receptor activity in mammary glands (Hun et al., 2002). In addition, TR2 has recently been shown to form a heterodimer with TR4 that can bind to the direct repeat 6 element of the hepatitis B virus (HBV) enhancer II region thus suppressing HBV gene expression (Lin et al., 2008).
Neat Serum
Polyclonal
IgG
WB
Rabbit
NR2C1
64 kDa
Fusion protein from the N-terminal region of mouse TR2.
Human, Mouse, Rat
AB_2492264
Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.
Liquid
Neat Serum
Neat serum
WB: 1:1000
Unconjugated
Specific for endogenous levels of the ~64 kDa TR2 protein.
Western blots performed on each lot.
For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.
After date of receipt, stable for at least 1 year at -20°C.
Blue Ice
NR2C 1 antibody, NR2C1 antibody, NR2C1_HUMAN antibody, NUCLEAR HORMONE RECEPTOR TR2 antibody, Nuclear receptor subfamily 2 Group C isoform antibody, Nuclear receptor subfamily 2 group C member 1 antibody, Orphan nuclear receptor TR2 antibody, Testicular receptor 2 antibody, TR 2 antibody, TR2 antibody, TR2-11 antibody
Q505F1
22025

Product Specific References for Applications and Species

Western Blot: Human
PMID Dilution Publication
21670149 not listed Cui, S., et al. 2011. Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells. Molecular and Cellular Biology, 31(16), pp.3298-3311.
17974920 not listed Tanabe, O., et al. 2007. The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription. Genes & Development, 21(21), pp.2832-2844.
17431400 not listed Tanabe, O., et al. 2007. Embryonic and fetal β‐globin gene repression by the orphan nuclear receptors, TR2 and TR4. The EMBO Journal, 26(9), pp.2295-2306.
Western Blot: Mouse
PMID Dilution Publication
24662048 not listed Cui, S., et al. 2014. PGC-1 coactivator activity is required for murine erythropoiesis. Molecular and Cellular Biology, 34(11), pp.1956-1965.
22042865 not listed Campbell, A.D., et al. 2011. Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes. Proceedings of the National Academy of Sciences, 108(46), pp.18808-18813.
21670149 not listed Cui, S., et al. 2011. Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells. Molecular and Cellular Biology, 31(16), pp.3298-3311.
17974920 not listed Tanabe, O., et al. 2007. The TR2 and TR4 orphan nuclear receptors repress Gata1 transcription. Genes & Development, 21(21), pp.2832-2844.
17431400 not listed Tanabe, O., et al. 2007. Embryonic and fetal β‐globin gene repression by the orphan nuclear receptors, TR2 and TR4. The EMBO Journal, 26(9), pp.2295-2306.

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