Anti-CASPR/Neurexin IV Antibody (K65/35)

Name: Anti-CASPR/Neurexin IV Antibody
Brand: NeuroMab
SKU: 75-001
Price: 374.0 USD
Availability: InStock

148 Citations

Adult rat hippocampus immunohistochemistry.

Immunoblot on adult rat brain membrane (RBM), and adult mouse brain membranes (MBM) from Caspr knockout (Caspr KO) and wild-type (WT) mice. Caspr KO sample courtesy of Drs. Ido Horresh and Ori Peles, The Weizmann Institute of Science.

Immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human cerebral cortex [HBM(Cx)], cerebellum [HBM(Cb)], and hippocampus [HBM(H)].

Immunostaining of Nav1.6 knock-in neurons (V5, green) in mouse cortex costained with Caspr (red). Image from publication CC-BY-4.0. PMID: 35672149

EGFP expression (green) was absent in the optic nerves of [gfap] dnVAMP2 mice supplied DOX (DOX-ON) and prevalent in astrocytes in the optic nerves of [gfap] dnVAMP2 mice on a diet without DOX (DOX-OFF) from gestation through adulthood (P70). EGFP expression in astrocytes was also elevated for a DOX-ON diet through development with DOX_OFF for P40 to P70 (30 d DOX-OFF). The paranodal region labeled with Caspr1 (red). DNA labelled with DAPI (blue). Image from publication CC-BY-4.0. PMID:36302632

Immunofluorescence showing labeling of CASPR (red) and Kv1.2(green) in the spinal cord of P21 Shank3(+ / +) and Shank3Δ11(−/−) mice. Image from publication CC-BY-4.0. PMID: 35726031

Sagittal section containing the vHPC immunolabeled with CASPR antibody (cat. 75-001, 1:500; cyan) in mice expressing an mCherry-labeled hM3Dq or a control virus in vHPC-to-mPFC projection neurons. Outlines demonstrating paranodes along an mCherry-labeled axon. Image from publication CC-BY-4.0. PMID:36949148

Immunofluorescence staining of the nodes of Ranvier analyzing hemiparanodal (Caspr1, cat. 75-001, 1:100; magenta) and nodal (pan-Nav, cyan) length. Image from publication CC-BY-4.0. PMID: 37388725

Immunofluorescence of teased fibers labeled for the paranodal protein CASPR (cat. 75-001, 1:500; green, arrows) and nuclei (in blue). Image from publication CC-BY-4.0. PMID:37315917

In mature myelinating cultures, SCs CASPR (cat.75-001, 1:500; white) can be detected in the characteristic staining pattern marking paranodes. Scale bar 5 μm. Paranodal CASPR co-localised on NFL-labelled axons (magenta). Scale bar: 5 μm. When colabelling with MPZ (green), CASPR is localised to paranodal loops adjacent to a node of Ranvier. Scale bar: 10 μm. Image from publication CC-BY-4.0. PMID:37642648

Representative immunofluorescence detection and IMARIS Z-stack surface rendering of CASPR (cat. 75-001, 1:1000) and pMLC in the optic nerves of 12-month-old Wt, PLPmut, and PLPmut/Rag1−/− mice. pMLC is localized at normal appearing nodes of Ranvier (arrowheads). In PLPmut mice, paranodal domains with irregularly small diameters are surrounded by additional pMLC aggregates (arrows). Image from publication CC-BY-4.0. PMID:37903797

Immunolabelling of type I HC (Spp1 + and CASPR1+(cat. 75-001, 1:400)), type II HC (Calre +), or all HC (Myo7a) for the SHAM, IDPN W6 and IDPN W12 mouse groups in the central ampulla of the horizontal canal (A1) and central utricular maculae (C1). Image from publication CC-BY-4.0. PMID:38019267

Adult rat brain membrane immunoblot.

Species Reactivity

Gerbil, Human, Mouse, Rat

Applications

ICC, IHC, IP, WB

Host Species

Mouse

Available Conjugates

490

550

594

650

Go to Full Product Details

Data Sheet

KO Validated

Trial Size

SKU: 75-001

Volume: 100 µL

Variant

Price:

$374.00

Quantity:

Product Details

Target

CASPR/Neurexin IV

Target Description

CASPR (Neurexin IV) is part of the neurexin family, which includes presynaptic proteins located in the presynaptic membrane of the brain.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

K65/35

Isotype

IgG1

Applications

ICC, IHC, IP, WB

Host Species

Mouse

Gene Name

Cntnap1 Caspr Nrxn4

Molecular Weight

220 kDa

Antigen

Fusion protein 1308-1381 (cytoplasmic domain) of rat Caspr (accession number P97846) produced recombinantly in E. Coli

Species Reactivity

Gerbil, Human, Mouse, Rat

Antibody Registry ID

AB_2083496

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4

Dilution Ranges

WB: 1:1000
IHC: 1:250
ICC: 1:500

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Contactin-associated protein 1 (Caspr) (Caspr1) (Neurexin IV) (Neurexin-4) (Paranodin) (p190)

UniProt Details

UniProt (Human): P78357
UniProt (Immunogen Species): P97846

Product Specific References for Applications and Species

Immunocytochemistry: Human | Mouse | Rat
Immunohistochemistry: Gerbil | Human | Mouse | Rat
Western Blot: Mouse | Rat
Additional Publications: Unspecified

Immunocytochemistry: Human
PMID	Dilution	Publication
37642648	1:500	Mutschler, C, et al. 2023. Schwann cells are axo-protective after injury irrespective of myelination status in mouse Schwann cell-neuron cocultures. Journal of Cell Science, 0.
35417746	1:400	Otani, Y., et al. 2022. Influence of Novel Readthrough Agents on Myelin Protein Zero Translation in the Peripheral Nervous System. Neuropharmacology, 109059.
33097924	not listed	García-León, J.A., et al. 2020. Generation of oligodendrocytes and establishment of an all-human myelinating platform from human pluripotent stem cells. Nature Protocols, 3716-3744.
28512649	1:40	Stratton, J.A., et al. 2017. Purification and Characterization of Schwann Cells from Adult Human Skin and Nerve. eNeuro, .

Immunocytochemistry: Mouse
PMID	Dilution	Publication
35672149	1:1000	Liu, H., et al. 2022. Direct Observation of Compartment-Specific Localization and Dynamics of Voltage-Gated Sodium Channels. The Journal of Neuroscience, 5482-5498.
32125730	not listed	Jarjour, A.A., et al. 2020. The formation of paranodal spirals at the ends of CNS myelin sheaths requires the planar polarity protein Vangl2. Glia, 1840-1858.
29138759	not listed	Browne, L., et al. 2017. Identification of persistent and resurgent sodium currents in spiral ganglion neurons cultured from the mouse cochlea.. Eneuro, .
26406915	1:200	Brügger, V., et al. 2015. HDAC1/2-Dependent P0 Expression Maintains Paranodal and Nodal Integrity Independently of Myelin Stability through Interactions with Neurofascins.. PLoS Biology, e1002258.
25362473	not listed	Ho, T.S., et al. 2015. A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier.. Nature Neuroscience, 1664-72.
19261867	1:1000	Sharkey, L.M., et al. 2009. The ataxia3 mutation in the N-terminal cytoplasmic domain of sodium channel Na(v)1.6 disrupts intracellular trafficking.. Journal of Neuroscience, 2733-2741.
19013247	1:500	O'Malley, H.A., et al. 2009. Loss of Na+ channel β2 subunits is neuroprotective in a mouse model of multiple sclerosis. . Molecular and Cellular Neuroscience, 143-155.

Immunocytochemistry: Rat
PMID	Dilution	Publication
39078369	1:200	Escobedo, G., et al. 2024. An evolutionarily conserved AnkyrinG-dependent motif clusters axonal K2P K+ channels. The Journal of Cell Biology, .

Immunohistochemistry: Gerbil
PMID	Dilution	Publication
38174817	1:500	Nabel, AL, et al. 2024. Development of myelination and axon diameter for fast and precise action potential conductance. Glia, 794-808.
27110919	not listed	Ko, K.W., et al. 2016. Serotonin modulates spike probability in the axon initial segment through HCN channels. Nature Neuroscience, 826-834.
26556176	1:1000	Seidl, A.H., et al. 2016. Systematic and differential myelination of axon collaterals in the mammalian auditory brainstem.. Glia, 487-494.

Immunohistochemistry: Human
PMID	Dilution	Publication
20838243	not listed	Howell, O.W., et al. 2010. Activated microglia mediate axoglial disruption that contributes to axonal injury in multiple sclerosis.. Journal of Neuropathology & Experimental Neurology, 1017-1033.

Immunohistochemistry: Mouse
PMID	Dilution	Publication
39178128	1:1000	Cassinotti, L.R., et al. 2024. Hidden hearing loss in a Charcot-Marie-Tooth type 1A mouse model. JCI Insight, .
39178117	not listed	Smith, K.E., et al. 2024. Developmental shaping of node of Ranvier geometry contributes to spike timing maturation in primary auditory afferents. Cell Reports, 114651.
38829008	not listed	Liu, K, et al. 2024. Remyelination-oriented clemastine treatment attenuates neuropathies of optic nerve and retina in glaucoma. Glia, .
38554941	1:50	Santos, E, et al. 2024. Recovery of Node of Ranvier Structure in Optic Nerve under Visual Deprivation. Neuroscience Research, .
38277269	1:200	Sell, L.B., et al. 2024. Protocol for isolating and processing mouse sciatic nerve fibers for confocal immunohistochemistry. STAR protocols, 102852.
38194969	not listed	Miyazaki, Y, et al. 2024. Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity. Cell Reports, 113634.
37903797	1:1000	Groh, J, et al. 2023. Microglia-mediated demyelination protects against CD8+ T cell-driven axon degeneration in mice carrying PLP defects. Nature communications, 6911.
37315917	1:500	Seixas, AI, et al. 2023. A RhoA-mediated Biomechanical Response in Schwann Cells Modulates Peripheral Nerve Myelination. Progress in Neurobiology, 102481.
36949148	1:5000	Koskinen, M.K., et al. 2023. Node of Ranvier Remodeling in Chronic Psychosocial Stress and Anxiety. Neuropsychopharmacology, .
36302632	1:50	Santos, E.N., et al. 2022. Effects of Visual Deprivation on Remodeling of Nodes of Ranvier in Optic Nerve. eNeuro, .
36273507	1:200	Takahashi, K., et al. 2022. Brexpiprazole Prevents Colitis-Induced Depressive-Like Behavior Through Myelination in the Prefrontal Cortex. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 110666.
35952494	1:400	Silva Oliveira Junior, M., et al. 2022. Myelin repair is fostered by the corticosteroid medrysone specifically acting on astroglial subpopulations. EBioMedicine, 104204.
35726031	1:200	Malara, M., et al. 2022. SHANK3 Deficiency Leads to Myelin Defects in the Central and Peripheral Nervous System. Cellular and Molecular Life Sciences, 371.
35246535	1:500	Meschkat, M., et al. 2022. White matter integrity in mice requires continuous myelin synthesis at the inner tongue. Nature communications, 1163.
35123326	1:200	Takahashi, K., et al. 2022. Antidepressant effects of Enterococcus faecalis 2001 through the regulation of prefrontal cortical myelination via the enhancement of CREB/BDNF and NF-κB p65/LIF/STAT3 pathways in olfactory bulbectomized mice. Journal of Psychiatric Research, 137-148.
34844642	not listed	Hay, C.M., et al. 2021. The oligodendrocyte-enriched orphan G protein-coupled receptor Gpr62 is dispensable for central nervous system myelination. Neural development, 16(1), pp.1-13.. Neural development, .
34648330	1:100	Lezmy, J., et al. 2021. Astrocyte Ca 2+-evoked ATP release regulates myelinated axon excitability and conduction speed. Science, eabh2858.
33605175	1:100	Nonaka, M., et al. 2021. Behavioral and Myelin-Related Abnormalities after Blast-Induced Mild Traumatic Brain Injury in Mice. Journal of Neurotrauma, 1551-1571.
33563723	1:100	Prades, S., et al. 2021. Functional P2X 7 Receptors in the Auditory Nerve of Hearing Rodents Localize Exclusively to Peripheral Glia. Journal of Neuroscience, 2615-2629.
33472865	1:200	Alam, M.M., et al. 2021. Deficiency of Microglial Autophagy Increases the Density of Oligodendrocytes and Susceptibility to Severe Forms of Seizures. eNeuro, .
33472075	1:200	Cullen, C.L., et al. 2021. Periaxonal and nodal plasticities modulate action potential conduction in the adult mouse brain. Cell Reports, 108641.
34825395	1:100	Newville, J., et al. 2020. Persistent myelin abnormalities in a third trimester‐equivalent mouse model of fetal alcohol spectrum disorder. . Alcoholism: Clinical and Experimental Research, 77-86.
33335032	1:100	Yang, S.M., et al. 2020. Neuron class-specific responses govern adaptive myelin remodeling in the neocortex. Science, eabd2109.
32557778	1:200	Ferreira, S., et al. 2020. Amyloidosis is associated with thicker myelin and increased oligodendrogenesis in the adult mouse brain. . Journal of neuroscience research, 1905-1932.
32170207	1:400	Otani, Y., et al. 2020. Upregulation of large myelin protein zero leads to Charcot-Marie-Tooth disease-like neuropathy in mice. Communications Biology, 121.
31769505	1:100	Yu, Y., et al. 2020. Microglial Hv1 proton channels promote white matter injuries after chronic hypoperfusion in mice. Journal of Neurochemistry, 350-367.
31933626	1:500	Alshammari, M.A., et al. 2019. Changes in the Fluorescence Tracking of NaV1.6 Protein Expression in a BTBR T+Itpr3tf/J Autistic Mouse Model. Neural Plasticity, 4893103.
31839007	not listed	Aziz, N.M., et al. 2019. Spatiotemporal development of spinal neuronal and glial populations in the Ts65Dn mouse model of Down syndrome. Journal of Neurodevelopmental Disorders, 35.
31641127	1:1000	Djannatian, M., et al. 2019. Two adhesive systems cooperatively regulate axon ensheathment and myelin growth in the CNS. Nature Communications, 4794.
31285774	1:100	Wang, M., et al. 2019. Astrocytic connexin 43 potentiates myelin injury in ischemic white matter disease. Theranostics, 4474-4493.
29300891	1:300	Scott, R., et al. 2019. Loss of Cntnap2 Causes Axonal Excitability Deficits, Developmental Delay in Cortical Myelination, and Abnormal Stereotyped Motor Behavior. Cereb Cortex, 586-597.
30555556	1:100	Qin, C., et al. 2018. Microglial TLR4-dependent autophagy induces ischemic white matter damage via STAT1/6 pathway. Theranostics, 5434-5451.
30240044	not listed	Liu, Y., et al. 2018. Distinct patterns of glia repair and remyelination in antibody‐mediated demyelination models of multiple sclerosis and neuromyelitis optica. . Glia, 2575-2588.
30149050	1:500	Smith, M.A., et al. 2018. Nodes of Ranvier in Glaucoma. Neuroscience, 104-118.
29664021	1:250	Srivastava, T., et al. 2018. A TLR/AKT/FoxO3 immune tolerance-like pathway disrupts the repair capacity of oligodendrocyte progenitors. Journal of Clinical Investigation, 2025-2041.
29556031	1:500	Hill, R.A., et al. 2018. Lifelong cortical myelin plasticity and age-related degeneration in the live mammalian brain. Nature Neuroscience, 683-695.
29431744	not listed	He, X., et al. 2018. A histone deacetylase 3-dependent pathway delimits peripheral myelin growth and functional regeneration. Nature Medicine, 338-351.
28722234	1:50	Manso, Y., et al. 2018. Minocycline reduces microgliosis and improves subcortical white matter function in a model of cerebral vascular disease. Glia, 34-46.
28556945	1:500	Davidson, N.L., et al. 2017. Leukemia/lymphoma-related factor (LRF) exhibits stage- and context-dependent transcriptional controls in the oligodendrocyte lineage and modulates remyelination. Journal of Neuroscience Research, 2391-2408.
28193689	1:100	Furusho, M., et al. 2017. Signaling by FGF Receptor 2, Not FGF Receptor 1, Regulates Myelin Thickness through Activation of ERK1/2-MAPK, Which Promotes mTORC1 Activity in an Akt-Independent Manner. Journal of Neuroscience, 2931-2946.
28174059	1:1000	Oshitari, T., et al. 2017. Alterations of myelin morphology and oligodendrocyte development in early stage of Alzheimer's disease mouse model. Neuroscience Letters, 102-106.
28123356	not listed	Yoshimura, T., et al. 2017. Developmental Changes in Expression of βIV Spectrin Splice Variants at Axon Initial Segments and Nodes of Ranvier. Frontiers in cellular neuroscience, 304.
27775720	1:100	Goebbels, S., et al. 2017. A neuronal PI(3,4,5)P 3-dependent program of oligodendrocyte precursor recruitment and myelination. Nature Neuroscience, 10-15.
27448245	1:50	Serwanski, D.R., et al. 2017. Heterogeneity of astrocyte and NG2 cell insertion at the node of ranvier.. Journal of Comparative Neurology, .
27581456	not listed	Marin, M.A., et al. 2016. Reassembly of excitable domains after CNS axon regeneration. Journal of Neuroscience, 36(35), pp.9148-9160.. Journal of Neuroscience, 9148-9160.
26909021	1:500	Alshammari, M.A., et al. 2016. Improved methods for fluorescence microscopy detection of macromolecules at the axon initial segment. . Frontiers in cellular neuroscience, 5.
26724902	1:200	Kawabata, S., et al. 2016. Grafted Human iPS Cell-Derived Oligodendrocyte Precursor Cells Contribute to Robust Remyelination of Demyelinated Axons after Spinal Cord Injury.. Stem Cell Reports, .
26203142	not listed	Zollinger, D.R., et al. 2015. The polarity protein Pals1 regulates radial sorting of axons. . Journal of Neuroscience, 10474-10484.
25948259	1:1000	Hirono, M., et al. 2015. BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells.. Journal of Neuroscience, 7082-7094.
25362471	not listed	Chang, K.J., et al. 2014. Glial ankyrins facilitate paranodal axoglial junction assembly.. Nature Neuroscience, 1673-81.
25319708	1:100	Xing, Y.L., et al. 2014. Adult neural precursor cells from the subventricular zone contribute significantly to oligodendrocyte regeneration and remyelination. . Journal of Neuroscience, 14128-14146.
21958379	not listed	Duflocq, A., et al. 2011. Characterization of the axon initial segment (AIS) of motor neurons and identification of a para-AIS and a juxtapara-AIS, organized by protein 4.1B.. BMC Biology, .
20838243	not listed	Howell, O.W., et al. 2010. Activated microglia mediate axoglial disruption that contributes to axonal injury in multiple sclerosis.. Journal of Neuropathology & Experimental Neurology, 1017-1033.
18522848	1:600	Windrem, M.S., et al. 2008. Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse.. Cell Stem Cell, 553-565.

Immunohistochemistry: Rat
PMID	Dilution	Publication
38246342	1:300	Huang, Z., et al. 2024. Enhancing axonal myelination: Clemastine attenuates cognitive impairment in a rat model of diffuse traumatic brain injury. Translational Research, .
37388725	1:100	Hecker, K, et al. 2023. Different Binding and Pathogenic Effect of Neurofascin and Contactin-1 Autoantibodies in Autoimmune Nodopathies. Frontiers in Immunology, 1189734.
36653191	1:1000	Petrosyan, H.A., et al. 2023. AAV Vector Mediated Delivery of NG2 Function Neutralizing Antibody and Neurotrophin NT-3 Improves Synaptic Transmission, Locomotion, and Urinary Tract Function after Contusion Spinal Cord Contusion Injury in Adult Rats. The Journal of Neuroscience, .
36163283	1:500	Hari, K., et al. 2022. GABA Facilitates Spike Propagation Through Branch Points of Sensory Axons in the Spinal Cord. Nature Neuroscience, 1288-1299.
30377733	1:400	Greguske, E.A., et al. 2019. Calyx junction dismantlement and synaptic uncoupling precede hair cell extrusion in the vestibular sensory epithelium during sub-chronic 3,3'-iminodipropionitrile ototoxicity in the mouse. Archives of Toxicology, 417-434.
30384417	1:500	Mao, Y., et al. 2018. The Effects of a Combination of Ion Channel Inhibitors in Female Rats Following Repeated Mild Traumatic Brain Injury. International Journal of Molecular Science, 3408.
28806920	1:500	O’Hare Doig, R.L., et al. 2017. Specific ion channels contribute to key elements of pathology during secondary degeneration following neurotrauma. BMC Neuroscience, 62.
28130923	1:100	Arancibia-Cárcamo, I.L., et al. 2017. Node of Ranvier length as a potential regulator of myelinated axon conduction speed. Elife, e23329.
26888923	not listed	Kim, K.X., et al. 2016. Maturation of NaV and KV channel topographies in the auditory nerve spike initiator before and after developmental onset of hearing function. . Journal of Neuroscience, 2111-2118.
25948259	1:1000	Hirono, M., et al. 2015. BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells.. Journal of Neuroscience, 7082-7094.
25294986	1:500	Tian, C., et al. 2014. Molecular identity of axonal sodium channels in human cortical pyramidal cells. . Frontiers in cellular neuroscience, 297.
22675541	not listed	Manning, C.F., et al. 2012. Benefits and pitfalls of secondary antibodies: why choosing the right secondary is of primary importance.. PLoS One, .
21734302	1:250	Lysakowski, A., et al. 2011. Molecular microdomains in a sensory terminal, the vestibular calyx ending.. Journal of Neuroscience, 10101-10114.

Western Blot: Mouse
PMID	Dilution	Publication
31910261	not listed	Lee, M., et al. 2020. Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain. Journal of Cell Biology, e201903033.
30504823	1:1000	Nelson, N.D., et al. 2020. Ankyrin-G Regulates Forebrain Connectivity and Network Synchronization via Interaction with GABARAP. Molecular Psychiatry, 2800-2817.
31933626	1:500	Alshammari, M.A., et al. 2019. Changes in the Fluorescence Tracking of NaV1.6 Protein Expression in a BTBR T+Itpr3tf/J Autistic Mouse Model. Neural Plasticity, 4893103.
29857015	1:1000	Huang, T., et al. 2019. In utero electroporation-based translating ribosome affinity purification identifies age-dependent mRNA expression in cortical pyramidal neurons. Neuroscience Research, 44-52.
25948259	not listed	Hirono, M., et al. 2015. BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells.. Journal of Neuroscience, 7082-7094.
24259518	1:2000	Dagley, L.F., et al. 2014. Quantitative proteomic profiling reveals novel region-specific markers in the adult mouse brain.. Proteomics, 241-261.

Western Blot: Rat
PMID	Dilution	Publication
38990251	1:1000	Yang, C., et al. 2024. Synaptic Vesicle-Related Proteins and Ubiquilin 2 in Cortical Synaptosomes Mediate Cognitive Impairment in Vascular Dementia Rats. Molecular Neurobiology, .

Additional Publications: Unspecified
PMID	Publication
28470148	Kleinecke, S., et al. 2017. Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy. Elife, 6, p.e23332.. Elife, e23332.
27474220	Doppler, K., et al. 2016. Auto-antibodies to contactin-associated protein 1 (Caspr) in two patients with painful inflammatory neuropathy. Brain, 2617-2630.
25732815	D''Este, E., et al. 2015. STED nanoscopy reveals the ubiquity of subcortical cytoskeleton periodicity in living neurons.. Cell Report, 1246-1251.
25707359	Chen, N., et al. 2015. Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes.. Biochimica et Biophysica Acta, 827-833.
25614025	Hinman, J.D., et al. 2015. Molecular disorganization of axons adjacent to human lacunar infarcts.. Brain, 736-745.
25552556	Jenkins, P.M., et al. 2015. Giant ankyrin-G: a critical innovation in vertebrate evolution of fast and integrated neuronal signaling.. PNAS: USA, 957-964.
25413837	Miyazaki, H., et al. 2014. Singular localization of sodium channel β4 subunit in unmyelinated fibres and its role in the striatum.. Nature Communications, 5525.
25362470	Trimarco, A., et al. 2014. Prostaglandin D2 synthase/GPR44: a signaling axis in PNS myelination.. Nature Neuroscience, 1682-1692.
25119334	Salewski, R.P., et al. 2014. Transplantation of neural stem cells clonally derived from embryonic stem cells promotes recovery after murine spinal cord injury. Stem Cells and Development, 36-50.
25031414	Bull, S.J., et al. 2014. Progressive disorganization of paranodal junctions and compact myelin due to loss of DCC expression by oligodendrocytes.. Journal of Neuroscience, 9768-9778.
24753086	Yamada, J., et al. 2014. Age-related differences in oligodendrogenesis across the dorsal-ventral axis of the mouse hippocampus.. Hippocampus, 1017-1029.
24631588	Leinders, M., et al. 2014. Differential distribution of PI3K isoforms in spinal cord and dorsal root ganglia: potential roles in acute inflammatory pain.. Pain, 1150-1160.
24599470	Battefeld, A., et al. 2014. Heteromeric Kv7.2/7.3 channels differentially regulate action potential initiation and conduction in neocortical myelinated axons.. Journal of Neuroscience, 3719-3732.
24431446	Yao, D., et al. 2014. Neuronal expression of GalNAc transferase is sufficient to prevent the age-related neurodegenerative phenotype of complex ganglioside-deficient mice.. Journal of Neuroscience, 880-891.
23842490	Koehler, K.R., et al. 2013. Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture.. Nature, 217-221.
23565257	Liu, R., et al. 2013. An efficient method for dorsal root ganglia neurons purification with a one-time anti-mitotic reagent treatment.. PLoS One, .
23447612	Petrosyan, H.A., et al. 2013. Neutralization of inhibitory molecule NG2 improves synaptic transmission, retrograde transport, and locomotor function after spinal cord injury in adult rats.. Journal of Neuroscience, 4032-4043.
23426679	Kondo, Y., et al. 2013. Spontaneous optic nerve compression in the osteopetrotic (op/op) mouse: a novel model of myelination failure.. Journal of Neuroscience, 3514-3525.
23365232	Chen, C.D., et al. 2013. The antiaging protein Klotho enhances oligodendrocyte maturation and myelination of the CNS.. Journal of Neuroscience, 1927-1939.
23291093	Horn, K.E., et al. 2013. DCC expression by neurons regulates synaptic plasticity in the adult brain.. Cell Report, 173-185.
22886464	Engelhardt, M., et al. 2013. Ankyrin-B structurally defines terminal microdomains of peripheral somatosensory axons.. Brian Structure and Function, 1005-1016.
23300814	Takano, M., et al. 2012. MRI characterization of paranodal junction failure and related spinal cord changes in mice.. PLoS One, .
23109147	Brambrink, A.M., et al. 2012. Isoflurane-induced apoptosis of oligodendrocytes in the neonatal primate brain.. Annals of Neurology, 525-535.
22911763	Bin, J.M., et al. 2012. Oligodendrocyte precursor cell transplantation into organotypic cerebellar shiverer slices: a model to study myelination and myelin maintenance.. PLoS One, .
22623668	Gasser, A., et al. 2012. An ankyrinG-binding motif is necessary and sufficient for targeting Nav1.6 sodium channels to axon initial segments and nodes of Ranvier.. Journal of Neuroscience, 7232-7243.
22449950	Bangratz, M., et al. 2012. A mouse model of Schwartz-Jampel syndrome reveals myelinating Schwann cell dysfunction with persistent axonal depolarization in vitro and distal peripheral nerve hyperexcitability when perlecan is lacking.. The American Journal of Pathology, 2040-2055.
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