Our Anti-Dopamine D2 receptor mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N186/29. It detects mouse and rat Dopamine D2 receptor, and is purified by Protein A chromatography. It is great for use in IHC.
Dopamine D2 receptor is encoded by the gene DRD2. DRD2 is a member of the G-protein coupled receptor 1 family that also includes D1, D3, D4 and D5. This G-protein coupled receptor inhibits adenylyl cyclase activity. DRD2 is expressed in the brain, colon, testis, and skeletal muscle tissue. Diseases associated with DRD2 include cocaine dependence, pathological gambling, and delusional disorder.
Purified by Protein A chromatography
1 mg/mL
Monoclonal
N186/29
IgG1
IHC
Mouse
Drd2
50 kDa
Fusion protein amino acids 211-374 (cytoplasmic, long form) of rat Dopamine D2 receptor (accession number P61169) produced recombinantly in E. Coli
Mouse, Rat
AB_11000721
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125
Unconjugated
Reacts with both Long and Short formsDoes not cross-react with Dopamine D3 receptor
Each new lot of antibody is quality control tested by IHC on either rat or mouse brain and confirmed to give the expected staining pattern.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
Escobar, A.P., et al. 2017. Mechanisms of Kappa Opioid Receptor Potentiation of Dopamine D2 Receptor Function in Quinpirole-Induced Locomotor Sensitization in Rats.. The International Journal of Neuropsychopharmacology, .
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