Anti-GluA1/GluR1 Glutamate Receptor Antibody (N355/1)
Our Anti-GluA1/GluR1 glutamate receptor mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N355/1. It detects human, mouse, and rat GluA1/GluR1 glutamate receptor, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.
Immunofluorescence staining of 14 DIV cultured rat cortical neuron with N355/1. Image courtesy of Brad Elmer and Kim McAllister (UCD).
Product Specific References for Applications and Species
- Immunocytochemistry: Human | Mouse | Rat
- Immunohistochemistry: Mouse | Rat
- Western Blot: Human | Mouse | Rat
- Additional Publications: Unspecified
| Immunocytochemistry: Human | ||
| PMID | Dilution | Publication |
| 34289359 | not listed | Li, L., et al. 2021. α2δ-1 switches the phenotype of synaptic AMPA receptors by physically disrupting heteromeric subunit assembly. Cell Reports, 109396. |
| 32604880 | not listed | García, F., et al. 2020. Astaxanthin Counteracts Excitotoxicity and Reduces the Ensuing Increases in Calcium Levels and Mitochondrial Reactive Oxygen Species Generation. Marine Drugs, 335. |
| Immunocytochemistry: Mouse | ||
| PMID | Dilution | Publication |
| 27986928 | 1:500 | Lee, S.J., et al. 2017. Presynaptic Neuronal Pentraxin Receptor Organizes Excitatory and Inhibitory Synapses. Journal of Neuroscience, 1062-1080. |
| Immunocytochemistry: Rat | ||
| PMID | Dilution | Publication |
| 37270156 | 1:100 | Nuwer, JL, et al. 2023. Long-term a5 GABA A Receptor Negative Allosteric Modulator Treatment Reduces NMDAR-mediated Neuronal Excitation and Maintains Basal Neuronal Inhibition. Neuropharmacology, 109587. |
| 35177616 | 1:250 | Hruska, M., et al. 2022. Nanoscale rules governing the organization of glutamate receptors in spine synapses are subunit specific. Nature communications, 920. |
| 34408636 | not listed | Martin, E.E., et al. 2021. Interaction and Subcellular Association of PRRT1/SynDIG4 With AMPA Receptors. Frontiers in Synaptic Neuroscience, 705664. |
| 34289359 | not listed | Li, L., et al. 2021. α2δ-1 switches the phenotype of synaptic AMPA receptors by physically disrupting heteromeric subunit assembly. Cell Reports, 109396. |
| 25918374 | not listed | Varea, O., et al. 2015. Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in contactin associated protein-like 2/Caspr2 knockout neurons.. PNAS USA, 6176-81. |
| Immunohistochemistry: Mouse | ||
| PMID | Dilution | Publication |
| 33613257 | 1:10 | Sahasrabudhe, A., et al. 2021. Cyfip1 Regulates SynGAP1 at Hippocampal Synapses. Frontier in Synaptic Neuroscience, 581714. |
| 33006315 | 1:300 | Chen, C., et al. 2020. Pathway-specific dysregulation of striatal excitatory synapses by LRRK2 mutations. Elife, e58997. |
| 30952813 | 1:500 | Yennawar, M., et al. 2019. AMPA Receptor Dysregulation and Therapeutic Interventions in a Mouse Model of CDKL5 Deficiency Disorder. Journal of Neuroscience, 4814-4828. |
| 25352748 | not listed | de Andrade, G.B., et al. 2014. Developmentally dynamic colocalization patterns of DSCAM with adhesion and synaptic proteins in the mouse retina.. Mol Vis, 1422-33. |
| Immunohistochemistry: Rat | ||
| PMID | Dilution | Publication |
| 32726631 | not listed | Holderith, N., et al. 2020. A High-Resolution Method for Quantitative Molecular Analysis of Functionally Characterized Individual Synapses. Cell Reports, 107968. |
| 31604597 | not listed | Schwenk, J., et al. 2019. An ER Assembly Line of AMPA-Receptors Controls Excitatory Neurotransmission and Its Plasticity. Neuron, 680-692. |
| Western Blot: Human | ||
| PMID | Dilution | Publication |
| 34289359 | 1:1000 | Li, L., et al. 2021. α2δ-1 switches the phenotype of synaptic AMPA receptors by physically disrupting heteromeric subunit assembly. Cell Reports, 109396. |
| Western Blot: Mouse | ||
| PMID | Dilution | Publication |
| 38886057 | not listed | Huang, Y, et al. 2024. Calcineurin and CK2 reciprocally regulate synaptic AMPA receptor phenotypes via α2δ-1 in spinal excitatory neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, . |
| 38581678 | 1:100000 | Molinaro, G, et al. 2024. Female-specific dysfunction of sensory neocortical circuits in a mouse model of autism mediated by mGluR5 and estrogen receptor α. Cell Reports, 114056. |
| 38577773 | 1:1000 | Yao, C, et al. 2024. Tiam1-mediated maladaptive plasticity underlying morphine tolerance and hyperalgesia. Brain, 0. |
| 38630836 | 1:1000 | Zhou, JJ, et al. 2024. Calcineurin regulates synaptic Ca2+-permeable AMPA receptors in hypothalamic presympathetic neurons via α2δ-1-mediated GluA1/GluA2 assembly. The Journal of Physiology, 2179-2197. |
| 38484863 | 1:1000 | Kelly-Castro, EC, et al. 2024. MARK1 regulates dendritic spine morphogenesis and cognitive functions in vivo. Experimental Neurology, 114752. |
| 37759527 | 1:1000 | Gruol, DL, et al. 2023. Impact of Elevated Brain IL-6 in Transgenic Mice on the Behavioral and Neurochemical Consequences of Chronic Alcohol Exposure. Cells, 0. |
| 37591201 | not listed | Boudkkazi, S, et al. 2023. A Noelin-organized extracellular network of proteins required for constitutive and context-dependent anchoring of AMPA-receptors. Neuron, 2544-2556.e9. |
| 37305696 | 1:1000 | Opland, C, et al. 2023. Activity-dependent tau cleavage by caspase-3 promotes neuronal dysfunction and synaptotoxicity. iScience, 106905. |
| 37146610 | 1:1000 | Li, L, et al. 2023. Tiam1 coordinates synaptic structural and functional plasticity underpinning the pathophysiology of neuropathic pain. Neuron, 2038-2050. |
| 37078449 | 1:5000 | Yokokawa, T., et al. 2023. Altered Expression of Synaptic Proteins and Adhesion Molecules in the Hippocampus and Cortex Following the Onset of Diabetes in Nonobese Diabetic Mice. Physiological Reports, e15673. |
| 36775097 | 1:1000 | Gruol, D.L., et al. 2023. Neuroimmune Interactions with Binge Alcohol Drinking in the Cerebellum of IL-6 Transgenic Mice. Neuropharmacology, 109455. |
| 36681359 | 1:5000 | Woodburn, S.C., et al. 2023. Depletion of Microglial BDNF Increases Susceptibility to the Behavioral and Synaptic Effects of Chronic Unpredictable Stress. Brain, Behavior, and Immunity, 127-138. |
| 36517241 | not listed | Chambon, J., et al. 2023. Early TNF-Dependent Regulation of Excitatory and Inhibitory Synapses on Striatal Direct Pathway Medium Spiny Neurons in the YAC128 Mouse Model of Huntington's Disease. The Journal of Neuroscience, 672-680. |
| 36519542 | 1:1000 | Ru, Q., et al. 2022. TIAM1-Mediated Synaptic Plasticity Underlies Comorbid Depression-like and Ketamine Antidepressant-like Actions in Chronic Pain. The Journal of Clinical Investigation, e158545. |
| 36465112 | 1:1000 | Mendoza, M.L., et al. 2022. KIBRA Regulates Activity-Induced AMPA Receptor Expression And Synaptic Plasticity In An Age-Dependent Manner. Iscience, 105623. |
| 33613257 | not listed | Sahasrabudhe, A., et al. 2021. Cyfip1 Regulates SynGAP1 at Hippocampal Synapses. Frontier in Synaptic Neuroscience, 581714. |
| 33298440 | 1:1000 | Cao, Q., et al. 2020. Targeting histone K4 trimethylation fortreatment of cognitive and synaptic deficits in mouse models of Alzheimer’s disease. Science Advances, eabc8096. |
| 33158444 | 1:1000 | Espinoza, S., et al. 2020. Neuronal surface P antigen (NSPA) modulates postsynaptic NMDAR stability through ubiquitination of tyrosine phosphatase PTPMEG. BMC Biology, 164. |
| 32634532 | 1:1000 | Gruol, D.L., et al. 2020. Alcohol and IL-6 Alter Expression of Synaptic Proteins in Cerebellum of Transgenic Mice With Increased Astrocyte Expression of IL-6. Neuroscience, 124-137. |
| 32160554 | not listed | De Rossi, P., et al. 2020. Neuronal BIN1 Regulates Presynaptic Neurotransmitter Release and Memory Consolidation. Cell Reports, 3520-3535. |
| 31216424 | 1:500 | Troyano-Rodriguez, E., et al. 2019. PRRT1 regulates basal and plasticity-induced AMPA receptor trafficking. Molecular Cell Neuroscience, 155-163. |
| 31200742 | 1:1000 | Micci, M.A., et al. 2019. Hippocampal stem cells promotes synaptic resistance to the dysfunctional impact of amyloid beta oligomers via secreted exosomes. Molecular neurodegeneration, 25. |
| 30625321 | 1:1000 | Ribic, A., et al. 2019. Synapse-Selective Control of Cortical Maturation and Plasticity by Parvalbumin-Autonomous Action of SynCAM 1. Cell reports, 381-393. |
| 30301947 | 1:2000 | Park, M.J., et al. 2018. Stress-induced changes in social dominance are scaled by AMPA-type glutamate receptor phosphorylation in the medial prefrontal cortex. Scientific Reports, 15008. |
| 29654490 | not listed | Rivera, D.S., et al. 2018. Long-Term, Fructose-Induced Metabolic Syndrome-Like Condition Is Associated with Higher Metabolism, Reduced Synaptic Plasticity and Cognitive Impairment in Octodon degus. molecular neurobiology, 9169-9187. |
| 29173281 | 1:1000 | Levenga, J., et al. 2017. AKT isoforms have distinct hippocampal expression and roles in synaptic plasticity. Elife, e30640. |
| 28864826 | 1:500 | Tanabe, Y., et al. 2017. IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α. Nature communications, 408. |
| 27334260 | not listed | Huang, L., et al. 2016. Post-anesthesia AMPA receptor potentiation prevents anesthesia-induced learning and synaptic deficits. Science translational medicine, 344ra85. |
| 27066908 | not listed | Vingtdeux, V., et al. 2016. CALHM1 deficiency impairs cerebral neuron activity and memory flexibility in mice. Scientific Reports, 24250. |
| 26818520 | 1:1000 | Bellizzi, M.J., et al. 2016. Platelet-Activating Factor Receptors Mediate Excitatory Postsynaptic Hippocampal Injury in Experimental Autoimmune Encephalomyelitis. Journal of Neuroscience, 1336-46. |
| 26089778 | 1:1000 | Tempia,F., et al. 2015. Parallel fiber to Purkinje cell synaptic impairment in a mouse model of spinocerebellar ataxia type 27.. Front Cell Neurosci., 205. |
| 25771393 | not listed | Cristino, L., et al. 2015. d-Aspartate oxidase influences glutamatergic system homeostasis in mammalian brain.. Neurobiol Aging, 1890-1902. |
| 24360280 | not listed | Parkhurst, C.N., et al. 2013. Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor.. Cell, 1596-609. |
| Western Blot: Rat | ||
| PMID | Dilution | Publication |
| 38700985 | 1:500 | Cuhadar, U, et al. 2024. Activity-driven synaptic translocation of LGI1 controls excitatory neurotransmission. Cell Reports, 114186. |
| 35038178 | 1:1000 | Zhou, J.J., et al. 2022. α2δ-1 Protein Promotes Synaptic Expression of Ca2+ Permeable-AMPA Receptors by Inhibiting GluA1/GluA2 Heteromeric Assembly in the Hypothalamus in Hypertension. Journal of neurochemistry, . |
| 34408636 | not listed | Martin, E.E., et al. 2021. Interaction and Subcellular Association of PRRT1/SynDIG4 With AMPA Receptors. Frontiers in Synaptic Neuroscience, 705664. |
| 34375626 | not listed | Moraga-Amaro, R., et al. 2021. Prenatal fluoxetine impairs non-hippocampal but not hippocampal memory in adult male rat offspring. Neuropharmacology, 108751. |
| 34289359 | 1:1000 | Li, L., et al. 2021. α2δ-1 switches the phenotype of synaptic AMPA receptors by physically disrupting heteromeric subunit assembly. Cell Reports, 109396. |
| 34227061 | not listed | Nagaraja, R.Y., et al. 2021. W246G Mutant ELOVL4 Impairs Synaptic Plasticity in Parallel and Climbing Fibers and Causes Motor Defects in a Rat Model of SCA34. Molecular Neurobiology, 4921-4943. |
| 33994940 | 1:1000 | Bach, E.C., et al. 2021. Chronic Ethanol Exposures Leads to a Negative Affective State in Female Rats That Is Accompanied by a Paradoxical Decrease in Ventral Hippocampus Excitability. Frontier in Neuroscience, 669075. |
| 32222474 | 1:1000 | Mazzocchetti, P. , et al. 2020. Low doses of Perampanel protect striatal and hippocampal neurons against in vitro ischemia by reversing the ischemia-induced alteration of AMPA receptor subunit composition. Neurobiology of Disease, 104848. |
| 31801062 | 1:1000 | Paskus, J.D., et al. 2019. Synaptic Kalirin-7 and Trio Interactomes Reveal a GEF Protein-Dependent Neuroligin-1 Mechanism of Action. Cell reports, 2944-2952.e5. |
| 30989630 | not listed | Marcello, E., et al. 2019. Amyloid-β Oligomers Regulate ADAM10 Synaptic Localization Through Aberrant Plasticity Phenomena. Molecular Neurobiology, 7136-7143. |
| 30927362 | 1:500 | Durante, V., et al. 2019. Alpha-synuclein targets GluN2A NMDA receptor subunit causing striatal synaptic dysfunction and visuospatial memory alteration. Brain, 1365-1385. |
| 30759095 | 1:1000 | Neumann, J.R, et al. 2019. The primate-specific peptide Y-P30 regulates morphological maturation of neocortical dendritic spines. Plos One, e0211151. |
| 30181277 | not listed | Zhang, J., et al. 2018. Glutamate-activated BK channel complexes formed with NMDA receptors. PNAS, E9006-E9014. |
| 29898386 | not listed | Opazo, P., et al. 2018. CaMKII Metaplasticity Drives Aβ Oligomer-Mediated Synaptotoxicity. Cell reports, 3137-3145. |
| 29397283 | 1:1000 | Piva, A., et al. 2018. The metaplastic effects of NMDA receptors blockade on reactivation of instrumental memories in rats. Neurobiology of learning and memory, 87-96. |
| 29218323 | not listed | Zhang, L., et al. 2017. SAP97 Binding Partner CRIPT Promotes Dendrite Growth In Vitro and In Vivo. eNeuro, 0175-17.2017. |
| 28902836 | not listed | Penn, A.C., et al. 2017. Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors. Nature, 384-388. |
| 28823933 | not listed | Stanic, J., et al. 2017. Rabphilin 3A: A novel target for the treatment of levodopa-induced dyskinesias. Neurobiology of Disease, 54-64. |
| 28152104 | 1:2000 | von Ossowski, L., et al. 2017. Cysteine 893 is a target of regulatory thiol modifications of GluA1 AMPA receptors. Plos One, e0171489. |
| 27565350 | 1:1000 | Loh, K.H., et al. 2016. Proteomic Analysis of Unbounded Cellular Compartments: Synaptic Clefts. Cell, 1295-1307. |
| 27271196 | 1:1000 | Gross, G.G., et al. 2016. An E3-ligase-based method for ablating inhibitory synapses. Nature Methods, 673-8. |
| 24103031 | 1:500 | Luo, P., et al. 2013. Downregulation of postsynaptic density-95-interacting regulator of spine morphogenesis reduces glutamate-induced excitotoxicity by differentially regulating glutamate receptors in rat cortical neurons.. FEBS J, 6114-27. |
| Additional Publications: Unspecified | ||
| PMID | Publication | |
| 26714288 | Rodrigo, M.A., et al. 2016. Dopamine receptor D5 deficiency results in a selective reduction of hippocampal NMDA receptor subunit NR2B expression and impaired memory.. Neuropharmacology., 222-235. | |
| 26306919 | Lv, J.M., et al. 2015. The Noncompetitive AMPAR Antagonist Perampanel Abrogates Brain Endothelial Cell Permeability in Response to Ischemia: Involvement of Claudin-5. Cellular and Molecular Neurobiology, 745-53. | |