Anti-GluN2C/NR2C Antibody (N422/18)

4 Citations

Our Anti-GluN2C/NR2C mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N422/18. It is KO validated, detects human, mouse, and rat GluN2C/NR2C, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.

Immunofluorescence staining of sections from adult GluN2C/NR2C wild-type (WT) and knockout (KO) mouse cerebellum with N422/18 (GluN2C/NR2C, red) and L106/83 (Gephyrin, green) TC supe. Tissue courtesy of Sharon Swanger and Stephen Traynelis (Emory).
Adult rat brain membrane immunoblot.
Immunoblot versus crude membrane fractions from GluN2C/NR2C knockout (KO) and wild-type (WT) mouse cerebella probed with N422/18 (top) and tubulin (bottom). Data courtesy of Bo-Shiun Chen (Augusta University) and reproduced with permission from Scientific Reports (2016 Chung et al, PMID 27845401).
Immunoblot from NAc synaptoneurosomal preparation of WT and GluN2C KO mice, confirming loss of GluN2C subunit. Image from publication CC-BY-4.0. PMID: 35867797
Immunofluorescence staining of sections from adult GluN2C/NR2C wild-type (WT) and knockout (KO) mouse cerebellum with N422/18 (GluN2C/NR2C, red) and L106/83 (Gephyrin, green) TC supe. Tissue courtesy of Sharon Swanger and Stephen Traynelis (Emory).
Immunofluorescence staining of sections from adult GluN2C/NR2C wild-type (WT) and knockout (KO) mouse cerebellum with N422/18 (GluN2C/NR2C, red) and L106/83 (Gephyrin, green) TC supe. Tissue courtesy of Sharon Swanger and Stephen Traynelis (Emory).
Adult rat brain membrane immunoblot.
Immunoblot versus crude membrane fractions from GluN2C/NR2C knockout (KO) and wild-type (WT) mouse cerebella probed with N422/18 (top) and tubulin (bottom). Data courtesy of Bo-Shiun Chen (Augusta University) and reproduced with permission from Scientific Reports (2016 Chung et al, PMID 27845401).
Immunoblot from NAc synaptoneurosomal preparation of WT and GluN2C KO mice, confirming loss of GluN2C subunit. Image from publication CC-BY-4.0. PMID: 35867797

Human, Mouse, Rat
ICC, IHC, WB
Mouse
490
550
594
650

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Data Sheet
KO Validated KO Validated

SKU: 75-411

Volume: 100 µL
1-2 business days
Price:
$319.00

Product Specific References for Applications and Species

Western Blot: Mouse
PMID Dilution Publication
358677971:500Shelkar, G.P., et al. 2022. Cocaine Preference and Neuroadaptations are Maintained by Astrocytic NMDA Receptors in the Nucleus Accumbens. Science Advances, eabo6574.
334215651:1000Liu, J., et al. 2021. Facilitation of GluN2C-containing NMDA receptors in the external globus pallidus increases firing of fast spiking neurons and improves motor function in a hemiparkinsonian mouse model. Neurobiology Disorders, 105254.
311101971:1000Shelkar, G.P., et al. 2019. Differential effect of NMDA receptor GluN2C and GluN2D subunit ablation on behavior and channel blocker-induced schizophrenia phenotypes. Scientific Reports, 7572.
Western Blot: Rat
PMID Dilution Publication
27845401not listedChung, C., et al. 2016. Neuroprotection Mediated through GluN2C-Containing N-methyl-D-aspartate (NMDA) Receptors Following Ischemia. Scientific Reports, 37033.

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