Anti-KChIP4 K+ channel Antibody (N423/75)

Name: Anti-KChIP4 K+ channel Antibody
Brand: NeuroMab
SKU: 75-406
Price: 319.0 USD
Availability: InStock

5 Citations

Our Anti-KChIP4 K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N423/75. It is KO validated, detects human, mouse, and rat KChIP4 K+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.

Adult rat hippocampus immunohistochemistry.

Immunoblot against adult rat brain membranes (RBM) and extracts of COS cells transiently transfected with untagged KChIP1, KChIP2, KChIP3, KChIP4 or Kv2.1 plasmid probed with N423/75 (left) or K55/82 (right) TC supe.

Adult rat hippocampus immunohistochemistry.

Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC, WB

Host Species

Mouse

Available Conjugates

490

550

594

650

Go to Full Product Details

Data Sheet

KO Validated

SKU: 75-406

Volume: 100 µL

Variant

Price:

$319.00

Quantity:

Product Details

Target

KChIP4 K+ channel

Target Description

Potassium voltage-gated channel interacting protein 4 is encoded by the gene KCNIP4. KCNIP4 is a member of the recoverin family. KCNIP4 is a regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels.KCNIP4 modulates KCND2 channel density, inactivation kinetics, and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. KCNIP4 is expressed in brain and bone marrow. Diseases associated with KCNIP4 include Synovial Angioma and Childhood Malignant Schwannoma.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N423/75

Isotype

IgG2a

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

KCNIP4 CALP KCHIP4

Molecular Weight

30 kDa

Antigen

Fusion protein amino acids 1-233 (full-length) of human KChIP4 (accession number Q3YAB7) produced recombinantly in E. Coli.

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2493100

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Dilution Ranges

WB: 1:1000
IHC: 1:500

Conjugate

Unconjugated

Specificity

Does not cross-react with KChIP1, KChIP2 or KChIP3

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Kv channel-interacting protein 4 (KChIP4) (A-type potassium channel modulatory protein 4) (Calsenilin-like protein) (Potassium channel-interacting protein 4)

UniProt Details

UniProt (Human): Q6PIL6
UniProt (Immunogen Species): Q3YAB7

Product Specific References for Applications and Species

Immunohistochemistry: Mouse | Rat
Western Blot: Mouse | Rat

Immunohistochemistry: Mouse
PMID	Dilution	Publication
26644354	not listed	Gong, B., et al. 2016. Developing high-quality mouse monoclonal antibodies for neuroscience research - approaches, perspectives and opportunities. New Biotechnology, 551-564.

Immunohistochemistry: Rat
PMID	Dilution	Publication
32899153	not listed	Alfaro-Ruíz, R., et al. 2020. Cellular and subcellular localisation of kv4-associated kchip proteins in the rat cerebellum. . International journal of molecular sciences, 6403.
32490811	1:400	Oláh, V.J., et al. 2020. Functional specification of CCK+ interneurons by alternative isoforms of Kv4. 3 auxiliary subunits. . Elife, e58515.
26644354	not listed	Gong, B., et al. 2016. Developing high-quality mouse monoclonal antibodies for neuroscience research - approaches, perspectives and opportunities. New Biotechnology, 551-564.
26239200	not listed	Cheng, C.F., et al. 2016. Coexpression of auxiliary subunits KChIP and DPPL in potassium channel Kv4-positive nociceptors and pain-modulating spinal interneurons.. Journal of Comparative Neurology, 846-873.

Western Blot: Mouse
PMID	Dilution	Publication
26644354	not listed	Gong, B., et al. 2016. Developing high-quality mouse monoclonal antibodies for neuroscience research - approaches, perspectives and opportunities. New Biotechnology, 551-564.

Western Blot: Rat
PMID	Dilution	Publication
26644354	not listed	Gong, B., et al. 2016. Developing high-quality mouse monoclonal antibodies for neuroscience research - approaches, perspectives and opportunities. New Biotechnology, 551-564.
26239200	not listed	Cheng, C.F., et al. 2016. Coexpression of auxiliary subunits KChIP and DPPL in potassium channel Kv4-positive nociceptors and pain-modulating spinal interneurons.. Journal of Comparative Neurology, 846-873.

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Anti-KChIP4 K+ channel Antibody (N423/75)

SKU: 75-406

Product Details

Product Specific References for Applications and Species

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