Our Anti-Kir2.3 K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N25/35. It detects human, mouse, and rat Kir2.3 K+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.
Inward rectifier potassium channel 4 or Kir2.3 is encoded by the gene KCNJ4. Kir2.3 is a member of the inward rectifier potassium ion channel family and plays a role in excitability of muscle cells and neurons. Kir2.3 is an integral membrane protein that is found expressed in heart, skeletal muscle, and several different brain regions including the hippocampus. Diseases associated with KCNJ4 include Long Qt Syndrome 9 and Seizures, Sensorineural Deafness, Ataxia, Mental Retardation, And Electrolyte Imbalance.
Purified by Protein A chromatography
1 mg/mL
Monoclonal
N25/35
IgG1
ICC, IHC, WB
Mouse
KCNJ4 IRK3
45 kDa
Fusion protein amino acids 390-445 of human Kir2.3 (accession number NP_032453) produced recombinantly in E. Coli
Human, Mouse, Rat
AB_2130742
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4
WB: 1:1000
Unconjugated
No cross-reactivity against Kir2.1 or Kir2.2
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
Frank, R., et al. 2017. Hierarchical organization and genetically separable subfamilies of PSD95 postsynaptic supercomplexes. Journal of neurochemistry, 504-511.
Sivagangabalan, G., et al. 2014. Regional ion channel gene expression heterogeneity and ventricular fibrillation dynamics in human hearts. PloS one, e82179.
Frank, R., et al. 2017. Hierarchical organization and genetically separable subfamilies of PSD95 postsynaptic supercomplexes. Journal of neurochemistry, 504-511.
Cavorla, M., et al. 2012. Striatal D2 receptors regulate dendritic morphology of medium spiny neurons via Kir2 channels. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2398-2409.
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![Immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] and probed with N25/35 (left) or N52A/42 (right) TC supe.](http://www.antibodiesinc.com/cdn/shop/products/validation-image-73-069-n25-35-wb-1_{width}x.jpg?v=1626904282)
![Immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] or cerebellum [HBM(Cb)] and probed with N25/35 (left) or N52A/42 (right) TC supe.](http://www.antibodiesinc.com/cdn/shop/products/validation-image-73-069-n25-35-wb-1_1024x.jpg?v=1626904282)
