Anti-Kv1.4 K+ Channel Antibody (K13/31)
Our Anti-Kv1.4 K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K13/31. It detects human, mouse, and rat Kv1.4 K+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB.
![Immunoblot on membrane fractions of whole rat (RBM) and mouse (MBM) brain and from human cerebral cortex [HBM(Cx)] and hippocampus [HBM(H)].](http://www.antibodiesinc.com/cdn/shop/products/validation-image-73-010-k13-31-wb-2_{width}x.jpg?v=1626902692)
Adult rat brain membrane immunoblot.
![Immunoblot on membrane fractions of whole rat (RBM) and mouse (MBM) brain and from human cerebral cortex [HBM(Cx)] and hippocampus [HBM(H)].](http://www.antibodiesinc.com/cdn/shop/products/validation-image-73-010-k13-31-wb-2_1024x.jpg?v=1626902692)
Product Specific References for Applications and Species
- Immunocytochemistry: Human | Mouse | Rat
- Immunohistochemistry: Mouse | Rat
- PLA: Mouse
- Western Blot: Human | Mouse | Rabbit| Rat
| Immunocytochemistry: Human | ||
| PMID | Dilution | Publication |
| 27872049 | 1:200 | Nishijima, Y., et al. 2017. Contribution of Kv1. 5 channel to hydrogen peroxide–induced human arteriolar dilation and its modulation by coronary artery disease. . Circulation research, 658-669. |
| Immunocytochemistry: Mouse | ||
| PMID | Dilution | Publication |
| 29802197 | 1:10 (supe) | Cheng, L., et al. 2018. Coupling of Smoothened to inhibitory G proteins reduces voltage-gated K+ currents in cardiomyocytes and prolongs cardiac action potential duration. . Journal of Biological Chemistry, 11022-11032. |
| 21507952 | 1:10 (supe) | Cheng, L., et al. 2011. Cortactin is required for N-cadherin regulation of Kv1.5 channel function.. The Journal of Biological Chemistry, 20478-20489. |
| 21233214 | 1:1000 | Fulton, S., et al. 2011. Contribution of Kv1.2 voltage-gated potassium channel to D2 autoreceptor regulation of axonal dopamine overflow.. The Journal of Biological Chemistry, 9360-9372. |
| Immunocytochemistry: Rat | ||
| PMID | Dilution | Publication |
| 33185190 | 1:100 | Sanders, S.S., et al. 2020. The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment. Elife, e56058. |
| 31164806 | 1:100 | Bonetto, G., et al. 2019. Selective axonal expression of the Kv1 channel complex in pre-myelinated GABAergic hippocampal neurons. . Frontiers in Cellular Neuroscience, 222. |
| 29168928 | 1:50 | Andersen, M.N., et al. 2018. Regulation of Kv1. 4 potassium channels by PKC and AMPK kinases.. Channels, 34-44. |
| 26442584 | not listed | Cobb, M.M., et al. 2015. Cell Cycle-dependent Changes in Localization and Phosphorylation of the Plasma Membrane Kv2.1 K+ Channel Impact Endoplasmic Reticulum Membrane Contact Sites in COS-1 Cells.. The Journal of Biological Chemistry, 29189-201. |
| 21352098 | not listed | Al-Sabi, A., et al. 2011. Position-dependent attenuation by Kv1.6 of N-type inactivation of Kv1.4-containing channels.. Biochemical Journal, 389-96. |
| 18509034 | not listed | Ogawa, Y., et al. 2008. Postsynaptic density-93 clusters Kv1 channels at axon initial segments independently of Caspr2.. Journal of Neuroscience, 5731-9. |
| Immunohistochemistry: Mouse | ||
| PMID | Dilution | Publication |
| 36640913 | 1:500 | Otuyemi, B., et al. 2023. Domain and Cell Type-specific Immunolocalisation of Voltage-gated Potassium Channels in the Mouse Striatum. Journal of Chemical Neuroanatomy, 102233. |
| 26269648 | not listed | Kole, M.J., et al. 2015. Selective loss of presynaptic potassium channel clusters at the cerebellar basket cell terminal pinceau in adam11 mutants reveals their role in ephaptic control of purkinje cell firing. . Journal of Neuroscience, 11433-11444. |
| 24494598 | not listed | Speca, D.J., et al. 2014. Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability.. Genes, Brain and Behavior, 394-408. |
| 22612819 | not listed | Menegola, M., et al. 2012. The importance of immunohistochemical analyses in evaluating the phenotype of Kv channel knockout mice.. Epilepsia, 142-149. |
| 17651419 | not listed | Wenzel, H.J., et al. 2007. Structural consequences of Kcna1 gene deletion and transfer in the mouse hippocampus.. Epilepsia, 2023-46. |
| Immunohistochemistry: Rat | ||
| PMID | Dilution | Publication |
| 24723263 | 1:100 | Dufour, M.A., et al. 2014. Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development.. Journal of Neuroscience Research, 981-99. |
| 23318870 | not listed | Ovsepian, S.V., et al. 2013. A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets.. The Journal of Physiology, 1771-91. |
| 22963239 | 1:200 | Zhu, Y., et al. 2012. Transforming growth factor beta induces sensory neuronal hyperexcitability, and contributes to pancreatic pain and hyperalgesia in rats with chronic pancreatitis.. Molecular Pain, 1744-8069. |
| 21451062 | not listed | Guan, D., et al. 2011. Postnatal development of A-type and Kv1- and Kv2-mediated potassium channel currents in neocortical pyramidal neurons.. Journal of Neurophysiology, 2976-88. |
| 18727953 | not listed | Monaghan, M.M., et al. 2008. Altered expression and localization of hippocampal A-type potassium channel subunits in the pilocarpine-induced model of temporal lobe epilepsy.. Neuroscience, 550-562. |
| 18668683 | not listed | Buniel, M., et al. 2008. Distribution of voltage-gated potassium and hyperpolarization-activated channels in sensory afferent fibers in the rat carotid body.. Journal of Comparative Neurology, 367-377. |
| PLA: Mouse | ||
| PMID | Dilution | Publication |
| 31639389 | not listed | Kilfoil, P.J., et al. 2019. Metabolic regulation of Kv channels and cardiac repolarization by Kvβ2 subunits.. Journal of Molecular and Cellular Cardiology, 93-106. |
| Western Blot: Human | ||
| PMID | Dilution | Publication |
| 38367666 | 1:1000 | Kabakov, AY, et al. 2024. E3 ubiquitin ligase rififylin (RFFL) has yin and yang effects on rabbit cardiac transient outward potassium currents (Ito) and corresponding channel proteins. The Journal of biological chemistry, 105759. |
| 29564531 | not listed | Willis, M., et al. 2018. Shaker-related voltage-gated potassium channels Kv1 in human hippocampus. . Brain Structure and Function, 2663-2671. |
| 27872049 | 1:2000 | Nishijima, Y., et al. 2017. Contribution of Kv1. 5 channel to hydrogen peroxide–induced human arteriolar dilation and its modulation by coronary artery disease. . Circulation research, 658-669. |
| Western Blot: Mouse | ||
| PMID | Dilution | Publication |
| 38194969 | not listed | Miyazaki, Y, et al. 2024. Oligodendrocyte-derived LGI3 and its receptor ADAM23 organize juxtaparanodal Kv1 channel clustering for short-term synaptic plasticity. Cell Reports, 113634. |
| 31639389 | 1:100 | Kilfoil, P.J., et al. 2019. Metabolic regulation of Kv channels and cardiac repolarization by Kvβ2 subunits. Journal of molecular and cell cardiology, 93–106. |
| 31639389 | 1:100 | Kilfoil, P.J., et al. 2019. Metabolic regulation of Kv channels and cardiac repolarization by Kvβ2 subunits.. Journal of Molecular and Cellular Cardiology, 93-106. |
| 29564531 | not listed | Willis, M., et al. 2018. Shaker-related voltage-gated potassium channels Kv1 in human hippocampus. . Brain Structure and Function, 2663-2671. |
| 29491011 | 1:200 | Zhou, L., et al. 2018. Celecoxib ameliorates seizure susceptibility in autosomal dominant lateral temporal epilepsy. . Journal of Neuroscience, 3346-3357. |
| 29476105 | 1:1000 | Nguyen, L.H., et al. 2018. mTOR-dependent alterations of Kv1.1 subunit expression in the neuronal subset-specific Pten knockout mouse model of cortical dysplasia with epilepsy. Scientific Reports, 3568. |
| 28270689 | 1:200 | Zhao, J.Y., et al. 2017. DNA methyltransferase DNMT3a contributes to neuropathic pain by repressing Kcna2 in primary afferent neurons.. Nature communications, 1-15. |
| 27874088 | 1:500 | Liang, L., et al. 2016. G9a participates in nerve injury-induced Kcna2 downregulation in primary sensory neurons. . Scientific reports, 1-14. |
| 27023865 | not listed | Schilling, J.M., et al. 2016. Electrophysiology and metabolism of caveolin-3-overexpressing mice. . Basic research in cardiology, 1-13. |
| 26611208 | not listed | Zhang, X., et al. 2016. Persistent increases in Ca(2+) influx through Cav1.2 shortens action potential and causes Ca(2+) overload-induced afterdepolarizations and arrhythmias.. Basic Research in Cardiology, 1-16. |
| 24494598 | not listed | Speca, D.J., et al. 2014. Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability.. Genes, Brain and Behavior, 394-408. |
| 22851675 | 1:500 | DiFranco, M., et al. 2012. The delayed rectifier potassium conductance in the sarcolemma and the transverse tubular system membranes of mammalian skeletal muscle fibers.. The Journal of General Physiology, 109-137. |
| 21943606 | 1:1000 | Sun, W., et al. 2011. DPP6 establishes the A-type K(+) current gradient critical for the regulation of dendritic excitability in CA1 hippocampal neurons.. Neuron, 1102-15. |
| 20685990 | not listed | Ohnishi, H., et al. 2010. Stress-evoked tyrosine phosphorylation of signal regulatory protein α regulates behavioral immobility in the forced swim test.. Journal of Neuroscience, 10472-10483. |
| 17651419 | not listed | Wenzel, H.J., et al. 2007. Structural consequences of Kcna1 gene deletion and transfer in the mouse hippocampus.. Epilepsia, 2023-46. |
| 16943244 | not listed | Pott, C., et al. 2007. Mechanism of shortened action potential duration in Na+-Ca2+ exchanger knockout mice.. American Journal of Physiology-Cell Physiology, C968-73. |
| Western Blot: Rabbit | ||
| PMID | Dilution | Publication |
| 20405051 | not listed | Xu, X., et al. 2010. Long-term fish oil supplementation induces cardiac electrical remodeling by changing channel protein expression in the rabbit model.. PLoS One, e10140. |
| Western Blot: Rat | ||
| PMID | Dilution | Publication |
| 33185190 | 1:500 | Sanders, S.S., et al. 2020. The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment. Elife, e56058. |
| 25599691 | not listed | Lee, K.Y., et al. 2015. N-methyl-D-aspartate receptors mediate activity-dependent down-regulation of potassium channel genes during the expression of homeostatic intrinsic plasticity.. Molecular Brain, 1-16. |
| 25510858 | 1:1000 | Mulholland, P.J., et al. 2015. Neuroplasticity of A-type potassium channel complexes induced by chronic alcohol exposure enhances dendritic calcium transients in hippocampus.. Psychopharmacology, 1995-2006. |
| 24472174 | not listed | Fan, L., et al. 2014. Impaired neuropathic pain and preserved acute pain in rats overexpressing voltage-gated potassium channel subunit Kv1.2 in primary afferent neurons.. Molecular Pain, 8. |
| 23536771 | 1:1000 | Brewster, A.L., et al. 2013. Rapamycin reverses status epilepticus-induced memory deficits and dendritic damage.. PLoS One, e57808. |
| 18668683 | not listed | Buniel, M., et al. 2008. Distribution of voltage-gated potassium and hyperpolarization-activated channels in sensory afferent fibers in the rat carotid body.. Journal of Comparative Neurology, 367-377. |
| 18667548 | 1:1000 | Kim, J., et al. 2008. Kv4 accessory protein DPPX (DPP6) is a critical regulator of membrane excitability in hippocampal CA1 pyramidal neurons.. Journal of Neurophysiology, 1835-47. |
| 17185748 | not listed | Vacher, H., et al. 2007. Regulation of Kv1 channel trafficking by the mamba snake neurotoxin dendrotoxin K.. The FASEB Journal, 906-14. |
| Additional Publications: Unspecified | ||
| PMID | Publication | |
| 22560931 | Jukkola, P.I., et al. 2012. K+ channel alterations in the progression of experimental autoimmune encephalomyelitis.. Neurobiology of Disease, 280-93. | |
| 20089912 | Ogawa, Y., et al. 2010. ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons. . Journal of Neuroscience, 1038-1048. | |
| 19968958 | Usman, H., et al. 2010. Potassium channel regulator KCNRG regulates surface expression of Shaker-type potassium channels.. Biochemical and Biophysical Research Communications, 1301-1305. | |
| 18937645 | Cartwright, T.A., et al. 2009. Atypical sialylated N-glycan structures are attached to neuronal voltage-gated potassium channels.. Bioscience reports, 301-313. | |