Anti-Kv2.1 K+ Channel Antibody (K89/34)

161 Citations

Our Anti-Kv2.1 K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K89/34. It is KO validated, detects human, mouse, and rat Kv2.1 K+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB.

Immunolabeling of principal neurons in the mouse neocortex specifically labeling Kv2.1 channels (1:500). The image is from a CLSM stack, pixel size is 100 nm. The image is kindly provided by Csaba Cserep, Institute of Experimental Medicine, Budapest, Hungary.
Adult rat hippocampus immunohistochemistry.
Adult rat brain membrane immunoblot.
Immunoblot on adult mouse brain membranes from two wild-type mice (MBM-WT) and one Kv2.1 knockout (MBM-Kv2.1-KO) mouse. Samples courtesy of Dr. Jeanne Nerbonne, Washington University School of Medicine.
Immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] and cerebellum [HBM(Cb)].
Representative super-resolution Airyscan images taken at a focal plane near the PM of CTL (black) and U18-treated (red) neurons fixed and immunolabeled for KV2.1 (cat. 75-014). Image from publication CC-BY-4.0. PMID:37507375
Representative maximum intensity projections from Wild-Type (WT) (black) and NPC1I1061T (red) cortical sagittal sections stained with Hoechst and immunolabeled for KV2.1 (cat. 75-014, 10ug/ml). Right, quantification of Kv2.1 total intensity, cluster size and cluster density of WT (black) and NPC1I1061T (red) neurons in the soma region. Image from publication CC-BY-4.0. PMID:37507375
Representative maximum intensity projections from WT (black) and NPC1I1061T (red) mouse cerebellar sagittal sections co-immunolabeled for Calbindin(cat. 75-448, 2ug/ml) , CaV1.2 (cat. 75-257, 5ug/ml) and KV2.1 (cat. 75-014, 10ug/ml). Image from publication CC-BY-4.0. PMID:37507375
Representative super-resolution TIRF images of CTL (black) and U18-treated (red) neurons co-immunolabeled for CaV1.2 (cat. 75-257, 5 ug/ml) and KV2.1 (cat. 75-014, 10 ug/ml). Image from publication CC-BY-4.0. PMID:37507375
Representative images of astrocytes labeled by AAV5-GfaABC1D-EBFP and neurons labeled by Kv2.1 (cat. 75-014, 1:100) in the hippocampal CA1sr and VMH. The measurement method of soma diameter is shown on the right. The yellow dashed lines show the three randomly selected branches of each cell. Image from publication CC-BY-4.0. PMID:38137092
Image of cultured hippocampal cells immune-labeled with antibodies specific for Kv2.1 (cat. 75-014, 1:400; green) and GLT-1 showing a pyramidal cell with a portion of the basal surface in contact with a GLT-1a positive astrocyte. The right panel shows an enlargement of the boxed area. Image from publication CC-BY-4.0. PMID:38362041
Immunolabeling of principal neurons in the mouse neocortex specifically labeling Kv2.1 channels (1:500). The image is from a CLSM stack, pixel size is 100 nm. The image is kindly provided by Csaba Cserep, Institute of Experimental Medicine, Budapest, Hungary.
Immunolabeling of principal neurons in the mouse neocortex specifically labeling Kv2.1 channels (1:500). The image is from a CLSM stack, pixel size is 100 nm. The image is kindly provided by Csaba Cserep, Institute of Experimental Medicine, Budapest, Hungary.
Adult rat hippocampus immunohistochemistry.
Adult rat brain membrane immunoblot.
Immunoblot on adult mouse brain membranes from two wild-type mice (MBM-WT) and one Kv2.1 knockout (MBM-Kv2.1-KO) mouse. Samples courtesy of Dr. Jeanne Nerbonne, Washington University School of Medicine.
Immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] and cerebellum [HBM(Cb)].
Representative super-resolution Airyscan images taken at a focal plane near the PM of CTL (black) and U18-treated (red) neurons fixed and immunolabeled for KV2.1 (cat. 75-014). Image from publication CC-BY-4.0. PMID:37507375
Representative maximum intensity projections from Wild-Type (WT) (black) and NPC1I1061T (red) cortical sagittal sections stained with Hoechst and immunolabeled for KV2.1 (cat. 75-014, 10ug/ml). Right, quantification of Kv2.1 total intensity, cluster size and cluster density of WT (black) and NPC1I1061T (red) neurons in the soma region. Image from publication CC-BY-4.0. PMID:37507375
Representative maximum intensity projections from WT (black) and NPC1I1061T (red) mouse cerebellar sagittal sections co-immunolabeled for Calbindin(cat. 75-448, 2ug/ml) , CaV1.2 (cat. 75-257, 5ug/ml) and KV2.1 (cat. 75-014, 10ug/ml). Image from publication CC-BY-4.0. PMID:37507375
Representative super-resolution TIRF images of CTL (black) and U18-treated (red) neurons co-immunolabeled for CaV1.2 (cat. 75-257, 5 ug/ml) and KV2.1 (cat. 75-014, 10 ug/ml). Image from publication CC-BY-4.0. PMID:37507375
Representative images of astrocytes labeled by AAV5-GfaABC1D-EBFP and neurons labeled by Kv2.1 (cat. 75-014, 1:100) in the hippocampal CA1sr and VMH. The measurement method of soma diameter is shown on the right. The yellow dashed lines show the three randomly selected branches of each cell. Image from publication CC-BY-4.0. PMID:38137092
Image of cultured hippocampal cells immune-labeled with antibodies specific for Kv2.1 (cat. 75-014, 1:400; green) and GLT-1 showing a pyramidal cell with a portion of the basal surface in contact with a GLT-1a positive astrocyte. The right panel shows an enlargement of the boxed area. Image from publication CC-BY-4.0. PMID:38362041

Human, Mouse, Rat
ICC, IHC, IP, WB
Mouse
490
550
594
650

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Data Sheet
KO Validated KO Validated Trial Size Trial Size

SKU: 75-014

Volume: 100 µL
1-2 business days
Price:
$374.00

Product Specific References for Applications and Species

Electrophysiology: Rat
PMID Dilution Publication
338541810.5 µg/mLDallas, M.L., et al. 2021. Hydrogen sulfide regulates hippocampal neuron excitability via S-sulfhydration of Kv2. 1. Scientific Reports, 8194.
Immunocytochemistry: Hamster
PMID Dilution Publication
31682765not listedYu, W., et al. 2019. Complexes formed with integrin-α5 and KCNB1 potassium channel wild type or epilepsy-susceptibility variants modulate cellular plasticity via Ras and Akt signaling. The FASEB Journal, 14680-9.
Immunocytochemistry: Human
PMID Dilution Publication
300916551:5 (supe)Kirmiz, M., et al. 2018. Remodeling neuronal ER–PM junctions is a conserved nonconducting function of Kv2 plasma membrane ion channels. Molecular Neurobiology of the Cell, 2410-32.
26503721not listedThiffault, I., et al. 2015. A novel epileptic encephalopathy mutation in KCNB1 disrupts Kv2.1 ion selectivity, expression, and localization.. The Journal of General Physiology, 399-410.
Immunocytochemistry: Mouse
PMID Dilution Publication
3750737510ug/mlCasas, M, et al. 2023. NPC1-dependent alterations in KV2.1-CaV1.2 nanodomains drive neuronal death in models of Niemann-Pick Type C disease. Nature , 4553.
3443561510 µg/mLNewkirk, G.S., et al. 2022. Kv2. 1 potassium channels regulate repetitive burst firing in extratelencephalic neocortical pyramidal neurons. Cerebral Cortex, 1055-76.
342804891:500Ding, T., et al. 2021. Kv2.1 expression in giant reticular neurons of the postnatal mouse brain. Journal of Chemical Neuroanatomy, 102005.
316008261:2 (supe)Kang, S.K., et al. 2019. Spectrum of KV2.1 Dysfunction in KCNB1‐Associated Neurodevelopmental Disorders. Annals of Neurology, 899-912.
280659421:100Casanovas, A., et al. 2017. Neuregulin 1-ErbB module in C-bouton synapses on somatic motor neurons: molecular compartmentation and response to peripheral nerve injury. Scientific Reports, 40155.
20853508not listedHermanstyne, T.O., et al. 2010. Immunolocalization of the voltage-gated potassium channel Kv2.2 in GABAergic neurons in the basal forebrain of rats and mice.. Journal of Comparative Neurology, 4298-310.
Immunocytochemistry: Rat
PMID Dilution Publication
3159486610 µg/mLKirmiz, M., et al. 2019. Neuronal ER–plasma membrane junctions organized by Kv2–VAP pairing recruit Nir proteins and affect phosphoinositide homeostasis. Journal of Biological Chemistry, 17735-57.
306673601:10 (supe)Andrews, N.P., et al. 2019. A toolbox of IgG subclass-switched recombinant monoclonal antibodies for enhanced multiplex immunolabeling of brain. eLife, e43322.
29395909not listedBerger, S.L., et al. 2018. Localized Myosin II Activity Regulates Assembly and Plasticity of the Axon Initial Segment. Neuron, 555-570.
26442584not listedCobb, M.M., et al. 2015. Cell Cycle-dependent Changes in Localization and Phosphorylation of the Plasma Membrane Kv2.1 K+ Channel Impact Endoplasmic Reticulum Membrane Contact Sites in COS-1 Cells.. The Journal of Biological Chemistry, 29189-201.
20853508not listedHermanstyne, T.O., et al. 2010. Immunolocalization of the voltage-gated potassium channel Kv2.2 in GABAergic neurons in the basal forebrain of rats and mice.. Journal of Comparative Neurology, 4298-310.
Immunohistochemistry: Hamster
PMID Dilution Publication
31591393not listedYu, W., et al. 2017. Oxidation of KCNB1 potassium channels triggers apoptotic integrin signaling in the brain. Cell Death & Disease, e2737.
28383553not listedYu, W., et al. 2017. Oxidation of KCNB1 potassium channels triggers apoptotic integrin signaling in the brain. Cell Death & Disease, e2737.
Immunohistochemistry: Human
PMID Dilution Publication
294832851:800Gayet-Primo, J., et al. 2018. Heteromeric KV2/KV8. 2 channels mediate delayed rectifier potassium currents in primate photoreceptors. Journal of Neuroscience, 3414-27.
Immunohistochemistry: Mouse
PMID Dilution Publication
381370921:100Li, Q, et al. 2023. Visualization and Characterization of the Brain Regional Heterogeneity of Astrocyte-Astrocyte Structural Interactions by Using Improved Iontophoresis with Dual-Fluorescent Dyes. Brain Sciences, 1644.
3750737510ug/mlCasas, M, et al. 2023. NPC1-dependent alterations in KV2.1-CaV1.2 nanodomains drive neuronal death in models of Niemann-Pick Type C disease. Nature , 4553.
373236481:1000Biro, L, et al. 2023. Post-weaning Social Isolation in Male Mice Leads to Abnormal Aggression and Disrupted Network Organization in the Prefrontal Cortex: Contribution of Parvalbumin Interneurons With or Without Perineuronal Nets. Neurobiology of Stress, 100546.
366409131:500Otuyemi, B., et al. 2023. Domain and Cell Type-specific Immunolocalisation of Voltage-gated Potassium Channels in the Mouse Striatum. Journal of Chemical Neuroanatomy, 102233.
36130488not listedCserép, C., et al. 2022. Microglial Control of Neuronal Development via Somatic Purinergic Junctions. Cell Reports, 111369.
352012681:500Császár, E., et al. 2022. Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions. The Journal of experimental medicine, .
346524201:1500Inamdar, S.M., et al. 2022. Differential impact of Kv8. 2 loss on rod and cone signaling and degeneration. Human Molecular Genetics, 1035-50.
34825141not listedBuettner, J.M., et al. 2021. Central synaptopathy is the most conserved feature of motor circuit pathology across spinal muscular atrophy mouse models. iScience, 103376.
33333928not listedSong, M.Y., et al. 2020. Tyrosine Phosphorylation of the Kv2. 1 Channel Contributes to Injury in Brain Ischemia. International Journal of Molecular Sciences, 9538.
329374501:200Schulien, A.J., et al. 2020. Targeted disruption of Kv2.1-VAPA association provides neuroprotection against ischeemic stroke in mice by declustering Kv2.1 channels. Science Advances, eaaz8110.
326846341:1000Asede, D., et al. 2020. Deletion of NRXN1α impairs long-range and local connectivity in amygdala fear circuit. Translational Pyschiatry, 242.
319870081:500Varga, D.P., et al. 2020. Microglia alter the threshold of spreading depolarization and related potassium uptake in the mouse brain. Journal of Cerebral Blood Flow and Metabolism, S67-80.
31831638not listedCserép, C., et al. 2020. Microglia monitor and protect neuronal function through specialized somatic purinergic junctions. Science, 528-537.
316641631:1000Thiebaud, N., et al. 2019. A unique olfactory bulb microcircuit driven by neurons expressing the precursor to glucagon-like peptide 1. Scientific Reports, 15542.
313452701:100Nishino, K., et al. 2019. Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1−Akt signaling pathway. Acta Neuropathologica Communications, 118.
309129771:100Salvany, S., et al. 2019. Localization and dynamic changes of neuregulin-1 at C-type synaptic boutons in association with motor neuron injury and repair. The FASEB Journal, 7833-51.
30050035not listedWei, Y., et al. 2018. Oxidation of KCNB1 channels in the human brain and in mouse model of Alzheimer’s disease. Cell Death & Disease, 820.
300126961:10 (supe)Kirmiz, M., et al. 2018. Identification of VAPA and VAPB as Kv2 Channel-Interacting Proteins Defining Endoplasmic Reticulum–Plasma Membrane Junctions in Mammalian Brain Neurons. The Journal of Neuroscience, 7562-84.
299548471:1000Rhomberg, T., et al. 2018. Vasoactive Intestinal Polypeptide-Immunoreactive Interneurons within Circuits of the Mouse Basolateral Amygdala. The Journal of Neuroscience, 6983-7003.
295023441:1000Dukkipati, S.S., et al. 2018. The vulnerability of spinal motoneurons and soma size plasticity in a mouse model of amyotrophic lateral sclerosis. The Journal of Physiology, 1723-45.
29403353not listedBishop, H.I., et al. 2018. Kv2 Ion Channels Determine the Expression and Localization of the Associated AMIGO-1 Cell Adhesion Molecule in Adult Brain Neurons.. Frontiers in Molecular Neuroscience, 1.
288562405 µg/mLPalacio, S., et al. 2017. Heterogeneity in Kv2 Channel Expression Shapes Action Potential Characteristics and Firing Patterns in CA1 versus CA2 Hippocampal Pyramidal Neurons. eNeuro, ENEURO.0267-17.2017.
280607011:1000Veres, J.M., et al. 2017. Perisomatic GABAergic synapses of basket cells effectively control principal neuron activity in amygdala networks. eLife, e20721.
277981881:100Yu, W., et al. 2016. Oxidation of KCNB1 Potassium Channels Causes Neurotoxicity and Cognitive Impairment in a Mouse Model of Traumatic Brain Injury.. Journal of Neuroscience, 11084-11096.
268918471:250Lasiene, J., et al. 2016. Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons.. Acta Neuropathologica Communications, 15.
249629011:100Mandikian, D., et al. 2014. Cell type-specific spatial and functional coupling between mammalian brain Kv2.1 K+ channels and ryanodine receptors.. Journal of Comparative Neurology, 3555-74.
Immunohistochemistry: Non-Human Primate
PMID Dilution Publication
347166171:300Muñoz, Y., et al. 2021. Light microscopic and heterogeneity analysis of astrocytes in the common marmoset brain.. Journal of Neuroscience Research, 3121-3147.
Immunohistochemistry: Rat
PMID Dilution Publication
33333928not listedSong, M.Y., et al. 2020. Tyrosine Phosphorylation of the Kv2. 1 Channel Contributes to Injury in Brain Ischemia. International Journal of Molecular Sciences, 9538.
32726631not listedHolderith, N., et al. 2020. A High-Resolution Method for Quantitative Molecular Analysis of Functionally Characterized Individual Synapses. Cell Reports, 107968.
3159486610 µg/mLKirmiz, M., et al. 2019. Neuronal ER–plasma membrane junctions organized by Kv2–VAP pairing recruit Nir proteins and affect phosphoinositide homeostasis. Journal of Biological Chemistry, 17735-57.
247232631:250Dufour, M.A., et al. 2014. Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development.. Journal of Neuroscience Research, 981-99.
22675541not listedManning, C.F., et al. 2012. Benefits and pitfalls of secondary antibodies: why choosing the right secondary is of primary importance.. PLoS One, e38313.
20853508not listedHermanstyne, T.O., et al. 2010. Immunolocalization of the voltage-gated potassium channel Kv2.2 in GABAergic neurons in the basal forebrain of rats and mice.. Journal of Comparative Neurology, 4298-310.
Immunoprecipitation: Mouse
PMID Dilution Publication
3092257010 µgYu, W., et al. 2019. Oxidation of KCNB1 potassium channels in the murine brain during aging is associated with cognitive impairment. Biochemical and Biophysical Research Communications, 665-9.
PLA: Mouse
PMID Dilution Publication
3750737510ug/mlCasas, M, et al. 2023. NPC1-dependent alterations in KV2.1-CaV1.2 nanodomains drive neuronal death in models of Niemann-Pick Type C disease. Nature , 4553.
SDS-digested freeze fracture replica-labeling: Mouse
PMID Dilution Publication
291273661:100Szoboszlay, M., et al. 2017. Objective quantification of nanoscale protein distributions. Scientific Reports, 15240.
SDS-digested freeze fracture replica-labeling: Rat
PMID Dilution Publication
291273661:100Szoboszlay, M., et al. 2017. Objective quantification of nanoscale protein distributions. Scientific Reports, 15240.
Western Blot: Hamster
PMID Dilution Publication
292643901:250Calhoun, J.D., et al. 2017. Characterization of a KCNB1 variant associated with autism, intellectual disability, and epilepsy. Neurology Genetics, e198.
Western Blot: Human
PMID Dilution Publication
341374431:1000Maverick, E.E., et al. 2021. Kv2 channel–AMIGO β-subunit assembly modulates both channel function and cell adhesion molecule surface trafficking. Journal of Cell Science, jcs256339.
32284408not listedMöller, L., et al. 2020. Determining the correct stoichiometry of Kv2.1/Kv6.4 heterotetramers, functional in multiple stoichiometrical configurations. PNAS, 9365-76.
294832851:800Gayet-Primo, J., et al. 2018. Heteromeric KV2/KV8. 2 channels mediate delayed rectifier potassium currents in primate photoreceptors. Journal of Neuroscience, 3414-27.
289386411:1000Liu, X., et al. 2017. Potential independent action of sigma receptor ligands through inhibition of the Kv2.1 channel. Oncotarget, 59345-58.
28432142not listedVullhorst, D., et al. 2017. Structural similarities between neuregulin 1–3 isoforms determine their subcellular distribution and signaling mode in central neurons. Journal of Neuroscience, 5232-5249.
28119464not listedNystoriak, M.A., et al. 2017. Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes. Science Signaling, eaaf9647.
26503721not listedThiffault, I., et al. 2015. A novel epileptic encephalopathy mutation in KCNB1 disrupts Kv2.1 ion selectivity, expression, and localization.. The Journal of General Physiology, 399-410.
251644381:500Torkamani, A., et al. 2014. De novo KCNB1 mutations in epileptic encephalopathy.. Annals of Neurology, 529-40.
Western Blot: Mouse
PMID Dilution Publication
375073754ug/mlCasas, M, et al. 2023. NPC1-dependent alterations in KV2.1-CaV1.2 nanodomains drive neuronal death in models of Niemann-Pick Type C disease. Nature , 4553.
373219921:500Oh, H, et al. 2023. Kv7/KCNQ Potassium Channels in Cortical Hyperexcitability and Juvenile Seizure-related Death in Ank2-mutant Mice. Nature Communications, 3547.
36842733not listedMarkandeya, Y.S., et al. 2023. Caveolin-3 and Caveolae Regulate Ventricular Repolarization. Journal of Molecular and Cellular Cardiology, 38-49.
331322032 ug/mLHawkins,N.A., et al. 2021. Epilepsy and neurobehavioral abnormalities in mice with a dominant-negative KCNB1 pathogenic variant. Neurobiology of Disease, 105141.
333930911:200Zhou, L., et al. 2020. Transient receptor potential vanilloid 4 activation inhibits the delayed rectifier potassium channels in hippocampal pyramidal neurons: An implication in pathological changes following pilocarpine-induced status epilepticus. Journal of Neuroscience Research, 914-26.
33333928not listedSong, M.Y., et al. 2020. Tyrosine Phosphorylation of the Kv2. 1 Channel Contributes to Injury in Brain Ischemia. International Journal of Molecular Sciences, 9538.
29265365not listedChao, R.Y., et al. 2018. Defective trafficking of Kv2.1 channels in MPTP-induced nigrostriatal degeneration. Journal of Neurochemistry, 483-97.
285046711:5 (supe)Fletcher, E.V., et al. 2017. Reduced sensory synaptic excitation impairs motor neuron function via Kv2.1 in spinal muscular atrophy. Nature Neuroscience, 905-16.
26538660not listedBishop, H.I., et al. 2015. Distinct Cell- and Layer-Specific Expression Patterns and Independent Regulation of Kv2 Channel Subtypes in Cortical Pyramidal Neurons.. Journal of Neuroscience, 14922-42.
26027736not listedVullhorst, D., et al. 2015. A negative feedback loop controls NMDA receptor function in cortical interneurons via neuregulin 2/ErbB4 signalling.. Nature Communications, 7222.
256708601:2 (supe)Nieves-Cintrón, M., et al. 2015. Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes.. The Journal of Biological Chemistry, 7918-29.
24494598not listedSpeca, D.J., et al. 2014. Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability.. Genes, Brain and Behavior, 394-408.
20853508not listedHermanstyne, T.O., et al. 2010. Immunolocalization of the voltage-gated potassium channel Kv2.2 in GABAergic neurons in the basal forebrain of rats and mice.. Journal of Comparative Neurology, 4298-310.
Western Blot: Rat
PMID Dilution Publication
365452391:800Li, X., et al. 2022. Intrathecal Administration of the Fat-mass and Obesity-associated Protein Inhibitor Mitigates Neuropathic Pain in Female Rats. Translational Perioperative and Pain Medicine, 478-487.
33333928not listedSong, M.Y., et al. 2020. Tyrosine Phosphorylation of the Kv2. 1 Channel Contributes to Injury in Brain Ischemia. International Journal of Molecular Sciences, 9538.
3159486610 µg/mLKirmiz, M., et al. 2019. Neuronal ER–plasma membrane junctions organized by Kv2–VAP pairing recruit Nir proteins and affect phosphoinositide homeostasis. Journal of Biological Chemistry, 17735-57.
312406011:1000Vullhorst, D., et al. 2019. NMDA receptors regulate neuregulin 2 binding to ER-PM junctions and ectodomain release. . Molecular neurobiology, 8345-8363.
28768770not listedWu, Y., et al. 2017. NMDA receptors mediate leptin signaling and regulate potassium channel trafficking in pancreatic β-cells. Journal of Biological Chemistry, 15512-24.
28432142not listedVullhorst, D., et al. 2017. Structural similarities between neuregulin 1–3 isoforms determine their subcellular distribution and signaling mode in central neurons. Journal of Neuroscience, 5232-5249.
22675541not listedManning, C.F., et al. 2012. Benefits and pitfalls of secondary antibodies: why choosing the right secondary is of primary importance.. PLoS One, e38313.
20853508not listedHermanstyne, T.O., et al. 2010. Immunolocalization of the voltage-gated potassium channel Kv2.2 in GABAergic neurons in the basal forebrain of rats and mice.. Journal of Comparative Neurology, 4298-310.
Additional Publications: Unspecified
PMID Publication
35238051Colecraft, H.M., et al. 2022. Controlling ion channel function with renewable recombinant antibodies. The Journal of Physiology, 2023-36.
26890139Frazzini, V., et al. 2016. Altered Kv2.1 functioning promotes increased excitability in hippocampal neurons of an Alzheimer''s disease mouse model.. Cell Death & Disease, e2100.
26240432Peltola, M.A., et al. 2016. AMIGO-Kv2.1 Potassium Channel Complex Is Associated With Schizophrenia-Related Phenotypes.. Schizophrenia Bulletin, 191-201.
26453299Wu, Y., et al. 2015. Concerted Trafficking Regulation of Kv2.1 and KATP Channels by Leptin in Pancreatic β-Cells.. The Journal of Biological Chemistry, 29676-90.
26442584Cobb, M.M., et al. 2015. Cell Cycle-dependent Changes in Localization and Phosphorylation of the Plasma Membrane Kv2.1 K+ Channel Impact Endoplasmic Reticulum Membrane Contact Sites in COS-1 Cells.. The Journal of Biological Chemistry, 29189-201.
26205295El Gebeily, G., et al. 2015. Estrogen regulation of the transient outward K(+) current involves estrogen receptor α in mouse heart.. Journal of Molecular and Cellular Cardiology, 85-94.
26115091He, K., et al. 2015. Regulation of Pro-Apoptotic Phosphorylation of Kv2.1 K+ Channels.. PLoS One, e0129498.
25908859Fox, P.D., et al. 2015. Induction of stable ER-plasma-membrane junctions by Kv2.1 potassium channels.. Journal of Cell Science, 2096-105.
25568127Liu, J., et al. 2015. Chromatin landscape defined by repressive histone methylation during oligodendrocyte differentiation.. Journal of Neuroscience, 352-65.
25525262Ednie, A.R., et al. 2015. Reduced sialylation impacts ventricular repolarization by modulating specific K+ channel isoforms distinctly.. The Journal of Biological Chemistry, 2769-83.
25182224Jensen, C.S., et al. 2015. Live-cell imaging of post-golgi transport vesicles in cultured hippocampal neurons.. Cell Molecular Neurobiology, 123-35.
25674050Moutal, A., et al. 2014. Differential neuroprotective potential of CRMP2 peptide aptamers conjugated to cationic, hydrophobic, and amphipathic cell penetrating peptides.. Frontiers in Neuroscience, 471.
25260053Krasowska, E., et al. 2014. Aberrant location of inhibitory synaptic marker proteins in the hippocampus of dystrophin-deficient mice: implications for cognitive impairment in duchenne muscular dystrophy.. PLoS One, e108364.
25220706Siddoway, B., et al. 2014. Potassium channel Kv2.1 is regulated through protein phosphatase-1 in response to increases in synaptic activity.. Neuroscience Letters, 142-7.
24928958McCord, M.C., et al. 2014. Syntaxin-binding domain of Kv2.1 is essential for the expression of apoptotic K+ currents.. The Journal of Physiology, 3511-21.
24723263Dufour, M.A., et al. 2014. Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development.. Journal of Neuroscience Research, 981-99.
24647953Shah, N.H., et al. 2014. Cyclin e1 regulates Kv2.1 channel phosphorylation and localization in neuronal ischemia.. Journal of Neuroscience, 4326-31.
24606584Kirizs, T., et al. 2014. Distinct axo-somato-dendritic distributions of three potassium channels in CA1 hippocampal pyramidal cells.. European Journal of Neuroscience, 1771-83.
24597762Wang, C.Y., et al. 2014. GDF15 regulates Kv2.1-mediated outward K+ current through the Akt/mTOR signalling pathway in rat cerebellar granule cells.. Biochemical Journal, 35-47.
24569993Jensen, C.S., et al. 2014. Specific sorting and post-Golgi trafficking of dendritic potassium channels in living neurons.. The Journal of Biological Chemistry, 10566-81.
24494598Speca, D.J., et al. 2014. Deletion of the Kv2.1 delayed rectifier potassium channel leads to neuronal and behavioral hyperexcitability.. Genes, Brain and Behavior, 394-408.
24477962King, A.N., et al. 2014. A unique ion channel clustering domain on the axon initial segment of mammalian neurons.. Journal of Comparative Neurology, 2594-608.
24445605Hund, T.J., et al. 2014. β(IV)-Spectrin regulates TREK-1 membrane targeting in the heart.. Cardiovascular Research, 166-75.
24431441Maguire, E.P., et al. 2014. Tonic inhibition of accumbal spiny neurons by extrasynaptic α4βδ GABAA receptors modulates the actions of psychostimulants.. Journal of Neuroscience, 823-38.
24375641Lopez-Izquierdo, A., et al. 2014. The absence of insulin signaling in the heart induces changes in potassium channel expression and ventricular repolarization.. American Journal of Physiology-Heart and Circulatory Physiology, H747-54.
23443966Pirger, Z., et al. 2014. Voltage-gated membrane currents in neurons involved in odor information processing in snail procerebrum.. Brian Structure and Function, 673-82.
24094875Cservenák, M., et al. 2013. Thalamic neuropeptide mediating the effects of nursing on lactation and maternal motivation.. PsychoneuroEndocrinology, 3070-84.
24086760Shepherd, A.J., et al. 2013. Chemokine co-receptor CCR5/CXCR4-dependent modulation of Kv2.1 channel confers acute neuroprotection to HIV-1 glycoprotein gp120 exposure.. PLoS One, e76698.
23918396McCord, M.C., et al. 2013. Convergent Ca2+ and Zn2+ signaling regulates apoptotic Kv2.1 K+ currents.. Proceedings of the National Academy of Science of the United States of America, 13988-93.
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