Anti-Kv4.2 K+ Channel Antibody (K57/1)

Name: Anti-Kv4.2 K+ Channel Antibody
Brand: NeuroMab
SKU: 75-016
Price: 374.0 USD
Availability: InStock

116 Citations

Our Anti-Kv4.2 K+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K57/1. It is KO validated, detects human, mouse, and rat Kv4.2 K+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB, EM.

Immunofluorescence staining of adult wild-type (WT) and Kv4.2 knockout (Kv4.2-/-) mouse hippocampus with K57/1 (red) and Kv2.1 rabbit (green).

Immunoblot against crude brain membranes from adult rat (RBM) and wild-type (MBM-WT) and Kv4.2 knockout (MBM-Kv4.2-KO) mice probed with K57/1 (left) or K89/41 (right) TC supe.

Confocal images of mouse cerebellar sagittal (left) or transverse (right) slices stained with a Kv4.2 antibody (cat. 75-016; red). AAV-GABRα6-GFP (green) was injected on the indicated postnatal days. Image from publication CC-BY-4.0. PMID:37095324

Confocal images showing tdT- (red) and GFP-positive GC dendrites (green) included in glomeruli, which are visualized by staining with three antibodies, Kv4.2 (cat. 75-016; purple in left panels or blue in right panels), vGLUT1 (blue), and vGAT (blue). Glomeruli are shown with arrows. Image from publication CC-BY-4.0. PMID:37095324

Immunoblot against crude C. elegans worm extracts and RBM.

Immunoblot against crude membranes from whole mouse (MBM) or rat (RBM) brain and from human cerebellum [HBM(Cb)], cerebral cortex [HBM(Cx)] or hippocampus [HBM(H)] and probed with K57/1 (left) or N52A/42 loading control (right) TC supe.

Immunofluorescence staining of adult wild-type (WT) and Kv4.2 knockout (Kv4.2-/-) mouse hippocampus with K57/1 (red) and Kv2.1 rabbit (green).

Species Reactivity

Human, Mouse, Rat

Applications

EM, ICC, IHC, IP, WB

Host Species

Mouse

Available Conjugates

490

550

594

650

Go to Full Product Details

Data Sheet

KO Validated

SKU: 75-016

Volume: 100 µL

Variant

Price:

$374.00

Quantity:

Product Details

Target

Kv4.2 K+ channel

Target Description

Kv4.2 K+ channel (Potassium voltage-gated channel subfamily D member 2 ) is a member of the mammalian Shal-related family and potassium voltage gated channel subunit family. Kv4 subunit family includes four Kv4 α subunits (Kv4.1, Kv4.2 and Kv4.3). However only Kv4.2 and Kv4.3 are predominantely expressed in the brain (Alfaro-Ruiz et al., 2019). Kv4.2 K+ is encoded by gene KCND2 in human. It helps to regulate the action potential's circadian rhythm firing in suprachiasmatic nucleus neurons. This process regulates the circadian rhythm of locomotor activity. It has been demonstrated that Kv 4.2 and Kv4.3 are often colocalized with pain-modulating molecules in rat spinal lamina II excitatory interneurons (Huang et al., 2005).

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

K57/1

Isotype

IgG1

Applications

EM, ICC, IHC, IP, WB

Host Species

Mouse

Gene Name

KCND2 KIAA1044

Molecular Weight

75-80 kDa

Antigen

Synthetic peptide amino acids 209 –225 (extracellular S1-S2 loop) of rat Kv4.2 (CGSSPGHIKELPSGERY; accession number Q63881)

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2131945

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4

Dilution Ranges

WB: 1:1000
IHC: 1:250
ICC: 1:250

Conjugate

Unconjugated

Specificity

No cross reactivity against rat Kv4.3

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Potassium voltage-gated channel subfamily D member 2 (Voltage-gated potassium channel subunit Kv4.2)

UniProt Details

UniProt (Human): Q9NZV8
UniProt (Immunogen Species): Q9NZV8

Product Specific References for Applications and Species

Array Tomography: Rat
Electron Microscopy: Mouse
HIstoblotting: Mouse
Immunocytochemistry: Human | Mouse | Rat
Immunohistochemistry: Mouse | Rat
Immunoprecipitation: Mouse | Rat
Western Blot: Human | Mouse | Rat
Additional Publications: Unspecified

Array Tomography: Rat
PMID	Dilution	Publication
26400949	1:300	Simkin, D., et al. 2015. Aging-related hyperexcitability in CA3 pyramidal neurons is mediated by enhanced A-type K+ channel function and expression. . Journal of Neuroscience, 13206-13218.

Electron Microscopy: Mouse
PMID	Dilution	Publication
35045307	1:25	Murphy, J.G., et al. 2022. R-type voltage-gated Ca2+ channels mediate A-type K+ current regulation of synaptic input in hippocampal dendrites. Cell reports, 110264.

Histoblotting: Mouse
PMID	Dilution	Publication
30634540	not listed	Alfaro-Ruíz, R., et al. 2019. Expression, cellular and subcellular localisation of Kv4. 2 and Kv4. 3 channels in the rodent hippocampus. . International journal of molecular sciences, 246.

Immunocytochemistry: Human
PMID	Dilution	Publication
31212013	1:100	Tabor, G.T., et al. 2019. A novel bungarotoxin binding site-tagged construct reveals MAPK-dependent Kv4. 2 trafficking.. Molecular and Cellular Neuroscience, 121-130.

Immunocytochemistry: Mouse
PMID	Dilution	Publication
32218435	1:200	Hu, J.H., et al. 2020. Activity-dependent isomerization of Kv4. 2 by Pin1 regulates cognitive flexibility. . Nature communications, 1-18.
29802197	1:10	Cheng, L., et al. 2018. Coupling of Smoothened to inhibitory G proteins reduces voltage-gated K+ currents in cardiomyocytes and prolongs cardiac action potential duration. . Journal of Biological Chemistry, 11022-11032.

Immunocytochemistry: Rat
PMID	Dilution	Publication
35508186	1:200	Li, Y., et al. 2022. Kv4. 2 phosphorylation by PKA drives Kv4. 2-KChIP2 dissociation, leading to Kv4. 2 out of lipid rafts and internalization.. American Journal of Physiology-Cell Physiology, C190-C201.
35508186	1:200	Li, Y., et al. 2022. Kv4.2 phosphorylation by PKA drives Kv4.2 - KChIP2 dissociation, leading to Kv4.2 out of lipid rafts and internalization. American journal of physiology. Cell physiology, C190-C201.
26456351	1 : 500	Gupte, R.P., et al. 2016. Convergent phosphomodulation of the major neuronal dendritic potassium channel Kv4.2 by pituitary adenylate cyclase-activating polypeptide.. Neuropharmacology, 291-308.
24569993	1:200	Jensen, C.S., et al. 2014. Specific sorting and post-Golgi trafficking of dendritic potassium channels in living neurons.. The Journal of Biological Chemistry, 10566-10581.
23836929	not listed	Sosanya, N.M., et al. 2013. Degradation of high affinity HuD targets releases Kv1.1 mRNA from miR-129 repression by mTORC1.. The Journal of Biology, 53-69.
23836929	not listed	Sosanya, N.M., et al. 2013. Degradation of high affinity HuD targets releases Kv1.1 mRNA from miR-129 repression by mTORC1.. The Journal of Biology, 53-69.

Immunohistochemistry: Mouse
PMID	Dilution	Publication
37708022	not listed	Jun, S, et al. 2023. Organization of Purkinje cell development by neuronal MEGF11 in cerebellar granule cells. Cell Reports, 113137.
37095324	not listed	Kim, T., et al. 2023. Developmental Timing-Dependent Organization of Synaptic Connections Between Mossy Fibers and Granule Cells in the Cerebellum. Communications Biology, 446.
36640913	1:500	Otuyemi, B., et al. 2023. Domain and Cell Type-specific Immunolocalisation of Voltage-gated Potassium Channels in the Mouse Striatum. Journal of Chemical Neuroanatomy, 102233.
33789707	not listed	Rhee, J.K., et al. 2021. Projection-dependent heterogeneity of cerebellar granule cell calcium responses.. Molecular brain, 1-17.
32824677	1:200	Hu, J.H., et al. 2020. P38 Regulates kainic acid-induced seizure and neuronal firing via Kv4. 2 phosphorylation. . International Journal of Molecular Sciences, 5921.
32822706	not listed	Tiwari, D., et al. 2020. The potassium channel Kv4. 2 regulates dendritic spine morphology, electroencephalographic characteristics and seizure susceptibility in mice.. Experimental Neurology, 113437.
31509753	not listed	Park, H., et al. 2019. Inputs from sequentially developed parallel fibers are required for cerebellar organization.. Cell Reports, 2939-2954.
30634540	not listed	Alfaro-Ruíz, R., et al. 2019. Expression, cellular and subcellular localisation of Kv4. 2 and Kv4. 3 channels in the rodent hippocampus. . International journal of molecular sciences, 246.
23940262	not listed	Sack, J.T., et al. 2013. Antibody-guided photoablation of voltage-gated potassium currents.. The Journal of General Physiology, 315-324.
22612819	not listed	Menegola, M., et al. 2012. The importance of immunohistochemical analyses in evaluating the phenotype of Kv channel knockout mice.. Epilepsia, 142-149.

Immunohistochemistry: Rat
PMID	Dilution	Publication
32899153	not listed	Alfaro-Ruíz, R., et al. 2020. Cellular and subcellular localisation of kv4-associated kchip proteins in the rat cerebellum. . International journal of molecular sciences, 6403.
27807163	1:500	Rizwan, A.P., et al. 2016. Long-Term potentiation at the mossy fiber–granule cell relay invokes postsynaptic second-messenger regulation of Kv4 channels.. Journal of Neuroscience, 11196-11207.
26456351	1 : 500	Schilling, J.M., et al. 2016. Convergent phosphomodulation of the major neuronal dendritic potassium channel Kv4.2 by pituitary adenylate cyclase-activating polypeptide.. Neuropharmacology, 291-308.
26400949	1:500	Simkin, D., et al. 2015. Aging-related hyperexcitability in CA3 pyramidal neurons is mediated by enhanced A-type K+ channel function and expression. . Journal of Neuroscience, 13206-13218.
24037673	not listed	Rainnie, D.G., et al. 2014. Distribution and functional expression of Kv4 family α subunits and associated KChIP β subunits in the bed nucleus of the stria terminalis.. Journal of Comparative Neurology, 609-25.
24037673	not listed	Rainnie, D.G., et al. 2014. Distribution and functional expression of Kv4 family α subunits and associated KChIP β subunits in the bed nucleus of the stria terminalis.. Journal of Comparative Neurology, 609-25.
22820170	1:100	Matsuyoshi, H., et al. 2012. Distinct cellular distributions of Kv4 pore-forming and auxiliary subunits in rat dorsal root ganglion neurons.. Life Sciences, 258-263.
22675541	not listed	Manning, C.F., et al. 2012. Benefits and pitfalls of secondary antibodies: why choosing the right secondary is of primary importance.. PLoS One, e38313.

Immunoprecipitation: Mouse
PMID	Dilution	Publication
32218435	2-3 ug	Hu, J.H., et al. 2020. Activity-dependent isomerization of Kv4. 2 by Pin1 regulates cognitive flexibility. . Nature communications, 1-18.
29306897	not listed	Huang, L., et al. 2018. Critical roles of Xirp proteins in cardiac conduction and their rare variants identified in sudden unexplained nocturnal death syndrome and Brugada syndrome in Chinese Han population. . Journal of the American Heart Association, e006320.

Immunoprecipitation: Rat
PMID	Dilution	Publication
26456351	1 : 200	Gupte, R.P., et al. 2016. Convergent phosphomodulation of the major neuronal dendritic potassium channel Kv4.2 by pituitary adenylate cyclase-activating polypeptide.. Neuropharmacology, 291-308.

Western Blot: Human
PMID	Dilution	Publication
31212013	1:2000	Tabor, G.T., et al. 2019. A novel bungarotoxin binding site-tagged construct reveals MAPK-dependent Kv4. 2 trafficking.. Molecular and Cellular Neuroscience, 121-130.
28560311	1:500	Hermanstyne, T.O., et al. 2017. Acute knockdown of Kv4. 1 regulates repetitive firing rates and clock gene expression in the suprachiasmatic nucleus and daily rhythms in locomotor behavior. . Eneuro, .
28560311	1:500	Hermanstyne, T.O., et al. 2017. Acute knockdown of Kv4. 1 regulates repetitive firing rates and clock gene expression in the suprachiasmatic nucleus and daily rhythms in locomotor behavior. . Eneuro, .
25190807	1:2000	Lin, L., et al. 2014. DPP6 domains responsible for its localization and function.. The Journal of Biological Chemistry, 32153-32165.

Western Blot: Mouse
PMID	Dilution	Publication
39191928	1:500	Cai, Y., et al. 2024. The Kv4 potassium channel modulator NS5806 attenuates cardiac hypertrophy in vivo and in vitro. Scientific Reports, 19839.
36842733	not listed	Markandeya, Y.S., et al. 2023. Caveolin-3 and Caveolae Regulate Ventricular Repolarization. Journal of Molecular and Cellular Cardiology, 38-49.
36427690	1:1000	Aceto, G., et al. 2022. Acute Restraint Stress Impairs Histamine Type 2 Receptor Ability To Increase The Excitability Of Medium Spiny Neurons In The Nucleus Accumbens. Neurobiology Of Disease, 105932.
34910912	not listed	Yokoi, N., et al. 2021. 14-3-3 proteins stabilize LGI1-ADAM22 levels to regulate seizure thresholds in mice. Cell Reports, 110107.
32824677	1:2000	Hu, J.H., et al. 2020. P38 Regulates kainic acid-induced seizure and neuronal firing via Kv4. 2 phosphorylation. . International Journal of Molecular Sciences, 5921.
32822706	not listed	Tiwari, D., et al. 2020. The potassium channel Kv4. 2 regulates dendritic spine morphology, electroencephalographic characteristics and seizure susceptibility in mice.. Experimental Neurology, 113437.
32218435	1:2000	Hu, J.H., et al. 2020. Activity-dependent isomerization of Kv4. 2 by Pin1 regulates cognitive flexibility. . Nature communications, 1-18.
31212067	not listed	Tiwari, D., et al. 2019. MicroRNA inhibition upregulates hippocampal A-type potassium current and reduces seizure frequency in a mouse model of epilepsy. . Neurobiology of disease, 104508.
31017573	1:1000	Carrillo-Reid, L., et al. 2019. Mutant huntingtin enhances activation of dendritic Kv4 K+ channels in striatal spiny projection neurons.. Elife, e40818.
29306897	not listed	Huang, L., et al. 2018. Critical roles of Xirp proteins in cardiac conduction and their rare variants identified in sudden unexplained nocturnal death syndrome and Brugada syndrome in Chinese Han population. . Journal of the American Heart Association, e006320.
27023865	not listed	Schilling, J.M., et al. 2016. Electrophysiology and metabolism of caveolin-3-overexpressing mice. . Basic research in cardiology, 1-13.
24795561	1:1000	Lugo, J.N., et al. 2014. Deletion of PTEN produces autism-like behavioral deficits and alterations in synaptic proteins.. Frontiers in Molecular Neuroscience, 27.
24375641	1:200	Lopez-Izquierdo, A., et al. 2014. The absence of insulin signaling in the heart induces changes in potassium channel expression and ventricular repolarization.. American Journal of Physiology-Heart and Circulatory Physiology, H747-H754.
24225951	not listed	Mercer, R.C., et al. 2013. The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6.. The Journal of Biological Chemistry, 37241-37255.
23940262	not listed	Sack, J.T., et al. 2013. Antibody-guided photoablation of voltage-gated potassium currents.. The Journal of General Physiology, 315-324.
22539834	not listed	Marionneau, C., et al. 2012. The sodium channel accessory subunit Navβ1 regulates neuronal excitability through modulation of repolarizing voltage-gated K⁺ channels.. Journal of Neuroscience, 5716-5727.
22311982	not listed	Foeger, N.C., et al. 2012. Augmentation of Kv4.2-encoded currents by accessory dipeptidyl peptidase 6 and 10 subunits reflects selective cell surface Kv4.2 protein stabilization.. The Journal of Biological Chemistry, 9640-9650.

Western Blot: Rat
PMID	Dilution	Publication
29996472	not listed	Kashino, Y., et al. 2018. ERK5 Phosphorylates K v 4.2 and Inhibits Inactivation of the A-Type Current in PC12 Cells. International Journal of Molecular Sciences, 2008.
29881800	not listed	Lai, Y.C., et al. 2018. Myocardial remodeling and susceptibility to ventricular tachycardia in a model of chronic epilepsy. . Epilepsia open, 213-223.
29881800	not listed	Lai, Y.C., et al. 2018. Myocardial remodeling and susceptibility to ventricular tachycardia in a model of chronic epilepsy. . Epilepsia open, 213-223.
27555091	1:1000	Brewster, A.L., et al. 2016. Early cardiac electrographic and molecular remodeling in a model of status epilepticus and acquired epilepsy. . Epilepsia, 1907-1915.
27259067	1:1000	Lei, Z., et al. 2016. Reduced expression of IA channels is associated with post-ischemic seizures.. Epilepsy Research, 40-48.
27147118	1:1000	Spencer, K.B., et al. 2016. FMRP mediates chronic ethanol‐induced changes in NMDA, Kv4. 2, and KChIP3 expression in the hippocampus. . Alcoholism: Clinical and Experimental Research, 1251-1261.
26456351	1 : 1000	Gupte, R.P., et al. 2016. Convergent phosphomodulation of the major neuronal dendritic potassium channel Kv4.2 by pituitary adenylate cyclase-activating polypeptide.. Neuropharmacology, 291-308.
26400949	1 : 1000	Simkin, D., et al. 2015. Aging-related hyperexcitability in CA3 pyramidal neurons is mediated by enhanced A-type K+ channel function and expression. . Journal of Neuroscience, 13206-13218.
25510858	1:1000	Mulholland, P.J., et al. 2015. Neuroplasticity of A-type potassium channel complexes induced by chronic alcohol exposure enhances dendritic calcium transients in hippocampus.. Psychopharmacology, 1995-2006.
23940262	not listed	Sack, J.T., et al. 2013. Antibody-guided photoablation of voltage-gated potassium currents.. The Journal of General Physiology, 315-324.
23536771	1:1000	Brewster, A.L., et al. 2013. Rapamycin reverses status epilepticus-induced memory deficits and dendritic damage.. PLoS One, e57808.
23066017	1:2000	Yao, J.J., et al. 2012. Neuritin activates insulin receptor pathway to up-regulate Kv4.2-mediated transient outward K+ current in rat cerebellar granule neurons.. The Journal of Biological Chemistry, 41534-41545.

Additional Publications: Unspecified
PMID	Publication
29524214	Shiotani, H., et al. 2018. Localization of nectin‐2α at the boundary between the adjacent somata of the clustered cholinergic neurons and its regulatory role in the subcellular localization of the voltage‐gated A‐type K+ channel Kv4. 2 in the medial habenula. . Journal of Comparative Neurology, 1527-1549.
25182224	Jensen, C.S., et al. 2014. Live-cell imaging of post-golgi transport vesicles in cultured hippocampal neurons.. Cell Molecular Neurobiology, 123-135.
24723263	Dufour, M.A., et al. 2014. Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development.. Journal of Neuroscience Research, 981-999.
23703525	Yao, J.J., et al. 2013. Neuregulin-1/ErbB4 signaling regulates Kv4.2-mediated transient outward K+ current through the Akt/mTOR pathway.. American Journal of Physiology-Cell Physiology, C197-C206.
22932868	Kaufmann, W.A., et al. 2013. Kv4.2 potassium channels segregate to extrasynaptic domains and influence intrasynaptic NMDA receptor NR2B subunit expression.. Brian Structure and Function, 1115-1132.
22833396	Xu, D., et al. 2013. Butyrate-induced colonic hypersensitivity is mediated by mitogen-activated protein kinase activation in rat dorsal root ganglia.. Gut, 1466-1474.
23055512	Kim, E., et al. 2012. Dynamic regulation of synaptic maturation state by voltage-gated A-type K+ channels in CA1 hippocampal pyramidal neurons.. Journal of Neuroscience, 14427-14432.
22122031	Smith, S.E., et al. 2012. Mutant LGI1 inhibits seizure-induced trafficking of Kv4.2 potassium channels.. Journal of Neurochemistry, 611-621.
21676499	Wykes, R., et al. 2012. Changes in the physiology of CA1 hippocampal pyramidal neurons in preplaque CRND8 mice. . Neurobiology of aging, 1609-1623.
21515848	Grabauskas, G., et al. 2012. Diabetic visceral hypersensitivity is associated with activation of mitogen-activated kinase in rat dorsal root ganglia.. Diabetes, 1743-1751.
21490210	Gross, C., et al. 2012. Fragile X mental retardation protein regulates protein expression and mRNA translation of the potassium channel Kv4.2.. Journal of Neuroscience, 5693-5698.
21451053	Hu, H.J., et al. 2012. Metabotropic glutamate receptor 5 regulates excitability and Kv4.2-containing K⁺ channels primarily in excitatory neurons of the spinal dorsal horn.. Journal of Neurophysiology, 3010-3021.
21329741	Prüss, H., et al. 2012. Potassium channel expression in adult murine neural progenitor cells.. Neuroscience, 19-29.
21273417	Lin, L., et al. 2012. AKAP79/150 impacts intrinsic excitability of hippocampal neurons through phospho-regulation of A-type K+ channel trafficking.. Journal of Neuroscience, 1323-1332.
22220205	Sethi, J., et al. 2011. Kv4. 2 mediates histamine modulation of preoptic neuron activity and body temperature. . PLoS One, e29134.
21943606	Sun, W., et al. 2011. DPP6 establishes the A-type K(+) current gradient critical for the regulation of dendritic excitability in CA1 hippocampal neurons.. Neuron, 1102-1115.
21507952	Cheng, L., et al. 2011. Cortactin is required for N-cadherin regulation of Kv1.5 channel function.. The Journal of Biological Chemistry, 20478-20489.
21451062	Guan, D., et al. 2011. Postnatal development of A-type and Kv1- and Kv2-mediated potassium channel currents in neocortical pyramidal neurons.. Journal of Neurophysiology, 2976-88.
19913943	Haberman, R.P., et al. 2011. Prominent hippocampal CA3 gene expression profile in neurocognitive aging.. Neurobiology of Aging, 1678-1692.
20943905	Norris, A.J., et al. 2010. Interdependent roles for accessory KChIP2, KChIP3, and KChIP4 subunits in the generation of Kv4-encoded IA channels in cortical pyramidal neurons.. Journal of Neuroscience, 13644-13655.
20849929	Dabrowska, J., et al. 2010. Expression and distribution of Kv4 potassium channel subunits and potassium channel interacting proteins in subpopulations of interneurons in the basolateral amygdala.. Neuroscience, 721-33.
20849929	Dabrowska, J., et al. 2010. Expression and distribution of Kv4 potassium channel subunits and potassium channel interacting proteins in subpopulations of interneurons in the basolateral amygdala.. Neuroscience, 721-33.
20709747	Foeger, N.C., et al. 2010. Co-assembly of Kv4 {alpha} subunits with K+ channel-interacting protein 2 stabilizes protein expression and promotes surface retention of channel complexes.. The Journal of Biological Chemistry, 33413-33422.
20650612	Bealer, S.L., et al. 2010. Autonomic and cellular mechanisms mediating detrimental cardiac effects of status epilepticus.. Epilepsy Research, 66-73.
20381592	Min, M.Y., et al. 2010. Roles of A-type potassium currents in tuning spike frequency and integrating synaptic transmission in noradrenergic neurons of the A7 catecholamine cell group in rats.. Neuroscience, 633-645.
20371829	Norris, A.J., et al. 2010. Molecular dissection of I(A) in cortical pyramidal neurons reveals three distinct components encoded by Kv4.2, Kv4.3, and Kv1.4 alpha-subunits.. Journal of Neuroscience, 5092-5101.
20045463	Lin, L., et al. 2010. KChIP4a regulates Kv4.2 channel trafficking through PKA phosphorylation.. Molecular and Cellular Neuroscience, 315-25.
19850106	Mulholland, P.J., et al. 2010. Inhibition of glutamate transporters couples to Kv4.2 dephosphorylation through activation of extrasynaptic NMDA receptors.. Neuroscience, 130-137.
19713751	Marionneau, C., et al. 2009. Proteomic analyses of native brain K(V)4.2 channel complexes.. Channels (Austin)., 287-297.
19703524	Qu, J., et al. 2009. The development of Kv4.2 expression in the retina.. Neuroscience Letters, 209-213.
19668710	Phuket, T.R., et al. 2009. Kv4 Channels Underlie the Subthreshold-Operating A-type K-current in Nociceptive Dorsal Root Ganglion Neurons.. Frontiers in Molecular Neuroscience, 3.
19596445	Aronica, E., et al. 2009. Expression and localization of voltage dependent potassium channel Kv4.2 in epilepsy associated focal lesions.. Neurobiology of Disease, 81-95.
19441798	Seikel, E., et al. 2009. Convergent modulation of Kv4.2 channel alpha subunits by structurally distinct DPPX and KChIP auxiliary subunits.. Biochemistry, 5721-5730.
19377470	Lewis, T.L., et al. 2009. Myosin-dependent targeting of transmembrane proteins to neuronal dendrites.. Nature Neuroscience, 568-576.
19185023	Harvey, M., et al. 2009. PPTX, a pentraxin domain-containing protein, interacts with the T1 domain of K v 4.. Journal of Neuroscience Research, 1841-1847.
19022416	Klemmer, P., et al. 2009. Proteomics analysis of immuno-precipitated synaptic protein complexes.. Journal of Proteomics, 82-90.
19038222	Jung, S.C., et al. 2008. Rapid, bidirectional remodeling of synaptic NMDA receptor subunit composition by A-type K+ channel activity in hippocampal CA1 pyramidal neurons.. Neuron, 657-671.
18987196	Day, M., et al. 2008. Differential excitability and modulation of striatal medium spiny neuron dendrites.. Journal of Neuroscience, 11603-11614.
18978958	Clark, B.D., et al. 2008. DPP6 Localization in Brain Supports Function as a Kv4 Channel Associated Protein.. Frontiers in Molecular Neuroscience, 8.
18727953	Monaghan, M.M., et al. 2008. Altered expression and localization of hippocampal A-type potassium channel subunits in the pilocarpine-induced model of temporal lobe epilepsy.. Neuroscience, 550-562.
18657617	Shin, M., et al. 2008. Mislocalization of h channel subunits underlies h channelopathy in temporal lobe epilepsy.. Neurobiology of Disease, 26-36.
18650329	Hammond, R.S., et al. 2008. Protein kinase a mediates activity-dependent Kv4.2 channel trafficking.. Journal of Neuroscience, 7513-7519.
18276729	Amarillo, Y., et al. 2008. Ternary Kv4.2 channels recapitulate voltage-dependent inactivation kinetics of A-type K+ channels in cerebellar granule neurons.. The Journal of Physiology, 2093-2106.
17635915	Gardoni, F., et al. 2007. SAP97 directs the localization of Kv4. 2 to spines in hippocampal neurons: regulation by CaMKII. . Journal of Biological Chemistry, 28691-28699.
17582333	Kim, J., et al. 2007. Regulation of dendritic excitability by activity-dependent trafficking of the A-type K+ channel subunit Kv4.2 in hippocampal neurons.. Neuron, 933-947.
17185748	Vacher, H., et al. 2007. Regulation of Kv1 channel trafficking by the mamba snake neurotoxin dendrotoxin K.. The FASEB Journal, 906-914.
17122053	Burkhalter, A., et al. 2006. Differential expression of I(A) channel subunits Kv4.2 and Kv4.3 in mouse visual cortical neurons and synapses.. Journal of Neuroscience, 12274-82.
17122053	Burkhalter, A., et al. 2006. Differential expression of I(A) channel subunits Kv4.2 and Kv4.3 in mouse visual cortical neurons and synapses.. Journal of Neuroscience, 12274-82.
17122038	Menegola, M., et al. 2006. Unanticipated region- and cell-specific downregulation of individual KChIP auxiliary subunit isotypes in Kv4.2 knock-out mouse brain.. Journal of Neuroscience, 2137-42.

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Anti-Kv4.2 K+ Channel Antibody (K57/1)

SKU: 75-016

Product Details

Product Specific References for Applications and Species

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