Anti-LAR/PTPRF (Receptor-Type Tyrosine-Protein Phosphatase) Antibody (N165/38)

Name: Anti-LAR/PTPRF (Receptor-Type Tyrosine-Protein Phosphatase) Antibody
Brand: NeuroMab
SKU: 75-193
Price: 329.0 USD
Availability: InStock

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Our Anti-LAR/PTPRF (Receptor-type tyrosine-protein phosphatase) mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N165/38. It detects human, mouse, and rat LAR/PTPRF (Receptor-type tyrosine-protein phosphatase), and is purified by Protein A chromatography. It is great for use in ICC, WB.

Adult rat brain membrane immunoblot.

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Species Reactivity

Human, Mouse, Rat

Applications

ICC, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Carrier-Free

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Data Sheet

SKU: 75-193

Volume: 100 µL

Variant

Price:

$329.00

Quantity:

Ships: 1-2 business days

Product Details

Target

LAR/PTPRF (Receptor-type tyrosine-protein phosphatase)

Target Description

Receptor-type tyrosine-protein phosphatase F or Leukocyte Common Antigen Related protein is encoded by the gene PTPRF and is a member of the protein tyrosine phosphatase (PTP) family. PRPRF is a transmembrane protein involved in regulation of insulin signaling, cell proliferation and cell migration. PTPRF functions in the regulation of epithelial cell-cell contacts at adherens junctions, as well as in the control of beta-catenin signaling. PTPRF is ubiquitously expressed. Diseases associated with PTPRF include Aplasia or hypoplasia of the breasts and/or nipples 2

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N165/38

Isotype

IgG2a

Applications

ICC, WB

Host Species

Mouse

Gene Name

PTPRF LAR

Molecular Weight

85 kDa (full-length is 210 kDa, smaller due to proteolysis into P-subunit containing transmembrane and intracellular domains)

Antigen

Fusion protein amino acids 1315-1607 (cytoplasmic C-terminus) of human LAR (accession number P10586) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_10675291

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.121

Conjugate

Unconjugated

Specificity

Does not cross-react with PTPRD or PTPRS

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR)

UniProt ID

P10586

Product Specific References for Applications and Species

Immunocytochemistry: Human | Mouse
Western Blot: Human | Mouse

Immunocytochemistry: Human
PMID	Dilution	Publication
23986473	not listed	Song, Y.S., et al. 2013. Trans-induced cis interaction in the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses.. Journal of Cell Science, 4926-4938.
23638386	not listed	Liu, W., et al. 2013. A new 12-gene diagnostic biomarker signature of melanoma revealed by integrated microarray analysis. PeerJ, e49.

Immunocytochemistry: Mouse
PMID	Dilution	Publication
38977849	not listed	Surana, S., et al. 2024. The tyrosine phosphatases LAR and PTPRδ act as receptors of the nidogen-tetanus toxin complex. EMBO Journal, .

Western Blot: Human
PMID	Dilution	Publication
30745530	1:1000	Sai, C., et al. 2019. Cyclin Dependent Kinase 1 (CDK1) Activates Cardiac Fibroblasts via Directly Phosphorylating Paxillin at Ser244. International Heart Journal, 374-383.

Western Blot: Mouse
PMID	Dilution	Publication
27352860	1:1000	Sarhan, A.R., et al. 2016. LAR protein tyrosine phosphatase regulates focal adhesions through CDK1. Journal of Cell Science, 2962-2971.

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Anti-LAR/PTPRF (Receptor-Type Tyrosine-Protein Phosphatase) Antibody (N165/38)

SKU: 75-193

Product Details

Product Specific References for Applications and Species

Bulk Order Anti-LAR/PTPRF (Receptor-Type Tyrosine-Protein Phosphatase) Antibody

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